Pulmonary thromboembolism in mild and asymptomatic COVID-19 cases. A clinical conundrum in post-COVID era
https://doi.org/10.4081/cdr.10.10646
Accepted: 8 September 2022
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We present a case series of patients with pulmonary embolism of unknown etiology who did not have any risk factors. According to the findings, the most likely cause of the pulmonary embolism was undiagnosed, asymptomatic, or mild Corona Virus disease-2019 (COVID-19) infections in the recent past. In the current post-pandemic era, where there has been a surge of sudden unexplained deaths and pulmonary embolism cases, this case series emphasizes the importance of pulmonary embolism evaluation in patients seeking medical care for dyspnea. Physicians should be aware of the possibility of pulmonary embolism as a late complication in patients with mild, asymptomatic, or undiagnosed COVID-19 infection.
Li JY, Wang HF, Yin P, et al. Clinical characteristics and risk factors for symptomatic venous thromboembolism in hospitalized COVID‐19 patients: A multicenter retrospective study. J Thromb Haemost 2021;19:1038-48. DOI: https://doi.org/10.1111/jth.15261
Loo J, Spittle DA, Newnham M. COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax 2021;76:412-20.
Spyropoulos AC, Levy JH, Ageno W, et al. Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost 2020;18:14929. DOI: https://doi.org/10.1111/jth.14929
Beckman M, Nyrén S, Kistner A. A case report of widespread pulmonary embolism in a middle-aged male seven weeks after asymptomatic suspected COVID 19 infection. Thromb J 2020;18:19. DOI: https://doi.org/10.1186/s12959-020-00235-w
Suzuki YJ, Nikolaienko SI, Shults NV, Gychka SG. COVID-19 patients may become predisposed to pulmonary arterial hypertension. Medical Hypotheses 2021;147:110483. DOI: https://doi.org/10.1016/j.mehy.2021.110483
Tudoran C, Tudoran M, Lazureanu VE, et al. evidence of pulmonary hypertension after SARS-CoV-2 infection in subjects without previous significant cardiovascular pathology. J Clin Med 2021;10:199. DOI: https://doi.org/10.3390/jcm10020199
Piazza G, Campia U, Hurwitz S, et al. Registry of arterial and venous thromboembolic complications in patients with COVID-19. J Am Coll Cardiol 2020;76:2060-2072. DOI: https://doi.org/10.1016/j.jacc.2020.08.070
Loo J, Spittle DA, Newnham M. COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax 2021;76:412-20. DOI: https://doi.org/10.1136/thoraxjnl-2020-216243
Guccione J, Ocazionez D, Aisenberg G, Odisio E. Coronavirus disease 2019 (COVID-19)-associated thromboembolic disease: a report of three patients with pulmonary embolism. Cureus 2020;12:e8583. DOI: https://doi.org/10.7759/cureus.8583
Singhania N, Bansal S, Nimmatoori DP, et al. Current overview on hypercoagulability in COVID-19. Am J Cardiovasc Drugs 2020;20:393-403. DOI: https://doi.org/10.1007/s40256-020-00431-z
Kanso M, Cardi T, Marzak H, et al. Delayed pulmonary embolism after COVID-19 pneumonia: A case report. Eur Heart J Case Rep 2020;4:1-4. DOI: https://doi.org/10.1093/ehjcr/ytaa449
Stein PD, Yaekoub AY, Matta F, et al. Resolution of pulmonary embolism on CT pulmonary angiography. Am J Roentgenol 2010;194:1263-8. DOI: https://doi.org/10.2214/AJR.09.3410
Rippinger C, Bicher M, Urach C, et al. Evaluation of undetected cases during the COVID-19 epidemic in Austria. BMC Infect Dis 2021;21:70. DOI: https://doi.org/10.1186/s12879-020-05737-6
Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol 2020;7:e438-40. DOI: https://doi.org/10.1016/S2352-3026(20)30145-9
Baldi E, Sechi GM, Mare C, et al. Lombardia CARe Researchers. Out-of-hospital cardiac arrest during the Covid-19 outbreak in Italy. N Engl J Med 2020;383:496-8. DOI: https://doi.org/10.1056/NEJMc2010418
Kiguchi T, Okubo M, Nishiyama C, et al. Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR). Resuscitation 2020;152:39-49. DOI: https://doi.org/10.1016/j.resuscitation.2020.02.044
Acharya V, Shirali A, Unnikrishnan B. Sudden unexplained deaths and COVID-19: is there more than what meets the eye? J R Coll Physicians Edinb 2021;51:310-7. DOI: https://doi.org/10.4997/jrcpe.2021.321
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