Original Articles
Vol. 35 No. 3 (2025)
https://doi.org/10.4081/ejtm.2025.13957
Plasma and salivary irisin response to moderate load/high volume resistance exercise in young, resistance-trained men
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 7 May 2025
Accepted: 26 May 2025
Published: 9 July 2025
Accepted: 26 May 2025
Published: 9 July 2025
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Irisin’s response to Resistance Exercise (RE) remains unclear. We investigated plasma and salivary irisin levels following acute moderate load/high volume (ML/HV) RE and explored correlations with muscle damage markers. Eight healthy, resistance-trained young males (23.3±2.5 yrs) completed one ML/HV RE session (full-body, 30 sets to failure, 70% 1RM). Plasma/saliva irisin, plasma Creatine Kinase (CK), and Visual Analogue Scale (VAS) for muscle soreness were assessed at baseline, 15 min, 24h, and 48h post-exercise. Plasma irisin increased significantly by ~9% (p=0.01) and salivary irisin by ~4% (p=0.02) at 15 min post-exercise, returning towards baseline by 24h. A strong correlation (rho=0.8, p=0.03) existed between percentage changes in plasma and salivary irisin at 15 min. CK and VAS peaked at 24h (p<0.001; p=0.02 vs 48h, respectively), but showed no significant correlation with irisin changes. Acute ML/HV RE elicits a transient increase in plasma and salivary irisin. Saliva may be a useful non-invasive proxy for irisin changes post-RE. This acute irisin response appears independent of EIMD markers in this population. Findings require confirmation in larger studies.
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Plasma and salivary irisin response to moderate load/high volume resistance exercise in young, resistance-trained men. (2025). European Journal of Translational Myology, 35(3). https://doi.org/10.4081/ejtm.2025.13957
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