Reviews | AI for Mobility Medicine
Vol. 35 No. 2 (2025)
https://doi.org/10.4081/ejtm.2025.13540
Longevity concept by regenerative medicine methods synergy: exosome therapy, functional medicine, and advanced multi-wavelengths laser therapy
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 28 December 2024
Accepted: 20 January 2025
Published: 8 May 2025
Accepted: 20 January 2025
Published: 8 May 2025
859
Views
363
Downloads
2
HTML
Regenerative medicine is one of the most important branches of medicine today and in the future and brings together all the methods to stop or even reverse the aging process. Regenerative medicine may include cellular therapies such as stem cell therapy or extracellular vesicle therapies such as exosomes and growth factor therapy. It may also involve the use of Photobiomodulation (PBM) and functional medicine treatments targets on mitochondrial medicine, to control the aging process. In this article, we have discussed the role, importance, rationale, overlap, and synergy of the joint application of these methods. Combining these regenerative medicine approaches can achieve better results in various medical indications. For longevity, any autoimmune disease, chronic disease, especially in elderly patients, this recommended combination seems to be very critical, for a higher survival rate in cell therapy methods. It is like a plant growing process that requires good quality seeds (cell therapy), light (targeted laser therapy) and good soil (functional medicine).
Downloads
Download data is not yet available.
Junqueira VB, Barros SB, Chan SS, et al. Aging and oxidative stress. Mol Aspects Med 2004;25:5-16. DOI: https://doi.org/10.1016/j.mam.2004.02.003
Rasmussen LJ, Sander M, Wewer UM, Bohr VA. Aging, longevity and health. Mech Ageing Dev 2011;132:522-32. DOI: https://doi.org/10.1016/j.mad.2011.07.004
Krumova K, Cosa G. Overview of reactive oxygen species. In S. Nonell, C. Flors, S. Nonell, and C. Flors (eds.), Singlet Oxygen: Applications in Biosciences and Nanosciences. The Royal Society of Chemistry, 2016, ch. 1, pp. 1-21. DOI: https://doi.org/10.1039/9781782622208-00001
Giampapa V, Pero R, Zimmerman M. The anti-aging solution: 5 simple steps to looking and feeling young: Turner Publishing Company; 2008.
Beck L. Leslie Beck's Longevity Diet: The Power Of Food To Slow Aging And Maintain Optimal Health And: Penguin Canada; 2011.
Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 2006;1067:10-21. DOI: https://doi.org/10.1196/annals.1354.003
Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development 2016;143:3-14. DOI: https://doi.org/10.1242/dev.130633
Alt EU, Senst C, Murthy SN, et al. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res 2012;8:215-25. DOI: https://doi.org/10.1016/j.scr.2011.11.002
Lushchak VI. Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact 2014;224:164-75. DOI: https://doi.org/10.1016/j.cbi.2014.10.016
Tudek B, Zdżalik-Bielecka D, Tudek A, et al. Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes. Free Radical Biol Med 2017;107:77-89. DOI: https://doi.org/10.1016/j.freeradbiomed.2016.11.043
Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbeck's Arch Surg 2006;391:499-510. DOI: https://doi.org/10.1007/s00423-006-0073-1
Marnett LJ. Oxy radicals, lipid peroxidation and DNA damage. Toxicology 2002;181:219-22. DOI: https://doi.org/10.1016/S0300-483X(02)00448-1
Asgari R, Mehran YZ, Weber HM, et al. Management of oxidative stress for cell therapy through combinational approaches of stem cells, antioxidants, and photobiomodulation. Eur J Pharmaceut Sci 2024;196:106715. DOI: https://doi.org/10.1016/j.ejps.2024.106715
Tumilaar SG, Hardianto A, Dohi H, et al. A comprehensive review of free radicals, oxidative stress, and antioxidants: overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds. J Chem 2024;5594386. DOI: https://doi.org/10.1155/2024/5594386
Patekar D, Kheur S, Bagul N, et al. Antioxidant defence system. Oral Maxillofac Pathol J 2013;4:309-15.
Gopčević KR, Rovčanin BR, Tatić SB, et al. Activity of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in different stages of colorectal carcinoma. Dig Dis Sci 2013;58:2646-52. DOI: https://doi.org/10.1007/s10620-013-2681-2
Orabi SA, Abou-Hussein S. Antioxidant defense mechanisms enhance oxidative stress tolerance in plants. A review. Curr Sci Int 2019;8:565-76.
Gulcin İ. Antioxidants and antioxidant methods: An updated overview. Arch Toxicol 2020;94:651-715. DOI: https://doi.org/10.1007/s00204-020-02689-3
Miles L, Miles MV, Tang PH, et al. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress. Clin Chim Acta 2005;360:87-96. DOI: https://doi.org/10.1016/j.cccn.2005.04.009
Menke T, Niklowitz P, Adam S, et al. Simultaneous detection of ubiquinol-10, ubiquinone-10, and tocopherols in human plasma microsamples and macrosamples as a marker of oxidative damage in neonates and infants. Analytical Biochem 2000;282:209-17. DOI: https://doi.org/10.1006/abio.2000.4579
Ghanbarzadeh A, Mehran YZ, Weber M, et al. Exosome therapy in combination with photodynamic therapy for severe and large-scale injuries and resisted wound treatment: case series. Sch J Med Case Rep 2024;3:379-84. DOI: https://doi.org/10.36347/sjmcr.2024.v12i03.037
Tocci A, Forte L. Mesenchymal stem cell: use and perspectives. Hematol J 2003;4:92-6. DOI: https://doi.org/10.1038/sj.thj.6200232
Gong M, Yu B, Wang J, et al. Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis. Oncotarget 2017;8:45200. DOI: https://doi.org/10.18632/oncotarget.16778
Qian X, An N, Ren Y, et al. Immunosuppressive effects of mesenchymal stem cells-derived exosomes. Stem Cell Rev Rep 2021;17:411-27. DOI: https://doi.org/10.1007/s12015-020-10040-7
Chen B-Y, Sung CW-H, Chen C, et al. Advances in exosomes technology. Clin Chim Acta 2019;493:14-9. DOI: https://doi.org/10.1016/j.cca.2019.02.021
Pegtel DM, Gould SJ. Exosomes. Ann Rev Biochem 2019;88:487-514. DOI: https://doi.org/10.1146/annurev-biochem-013118-111902
Robbins PD. Extracellular vesicles and aging. Stem Cell Investig 2017;4:98. DOI: https://doi.org/10.21037/sci.2017.12.03
Takasugi M. Emerging roles of extracellular vesicles in cellular senescence and aging. Aging Cell 2018;17:e12734. DOI: https://doi.org/10.1111/acel.12734
Picca A, Guerra F, Calvani R, et al. Mitochondrial dysfunction and aging: Insights from the analysis of extracellular vesicles. Int J Molec Sci 2019;20:805. DOI: https://doi.org/10.3390/ijms20040805
Chan BD, Wong WY, Lee MML, et al. Exosomes in inflammation and inflammatory disease. Proteomics 2019;19:1800149. DOI: https://doi.org/10.1002/pmic.201800149
Pan W, Zhu Y, Meng X, et al. Immunomodulation by exosomes in myocardial infarction. J Cardiovasc Translat Res 2019;12:28-36. DOI: https://doi.org/10.1007/s12265-018-9836-7
Ailioaie LM, Litscher G, Weber M, et al. Innovations and challenges by applying sublingual laser blood irradiation in juvenile idiopathic arthritis. Int J Photoen 2014;2014:130417. DOI: https://doi.org/10.1155/2014/130417
Chiran DA, Litscher G, Weber M, et al. Intravenous laser blood irradiation increases efficacy of etanercept in selected subtypes of juvenile idiopathic arthritis: an innovative clinical research approach. Evid Based Complement Alternat Med 2013;2013:168134. DOI: https://doi.org/10.1155/2013/168134
Hoseinzade F, Tehrani H, Mirshams S, et al. Effect of Intrauterine Laser Therapy at the IVF Success Rate on Infertile Patients with a History of IVF Failure: A Pilot Non-Blinded Study. Adv Sexual Med 2024;14:21-30. DOI: https://doi.org/10.4236/asm.2024.143003
Weber M. Intra-articular exosome and intraarticular laser therapy for osteoarthritis; preliminary non-surgical approach. Sch J App Med Sci 2024;5:607-16. DOI: https://doi.org/10.36347/sjams.2024.v12i05.016
Weber M, Mehran YZ, Kazerouni SMH, et al. Innovative laser therapy in chronic wound healing disorders; multi wavelengths transdermal and interstitial laser therapy. Therapy 2023;19:26.
Weber MH, Fußgänger-May T, Wolf T. Intravenous Laser Blood Irradiation—Introduction of a New Therapy. Deutsche Zeitschrift für Akupunktur 2007;50:12-23. DOI: https://doi.org/10.1078/0415-6412-00282
Noorizadeh S, Tehranchi M, Taleghani F, et al. Effects of photobiomodulation therapy with 808 nm diode laser on the expression of RANKL and OPG genes in exosomes isolated from MG63 osteoblast-like cells: An in-vitro study. Photodiagnosis Photodyn Ther 2025;53:104566. DOI: https://doi.org/10.1016/j.pdpdt.2025.104566
Hamblin MR, de Sousa MVP, Arany PR, Carroll JD, Patthoff D, editors. Low level laser (light) therapy and photobiomodulation: the path forward. Proc SPIE 9309, Mechanisms for Low-Light Therapy X, 930902, 2015. DOI: https://doi.org/10.1117/12.2084049
Litscher G, Weber MH. 10th Anniversary of the International Society for Medical Laser Applications. Med Acupunct 2022;34:217-9. DOI: https://doi.org/10.1089/acu.2022.0038
Cronshaw M, Parker S, Arany P. Feeling the heat: evolutionary and microbial basis for the analgesic mechanisms of photobiomodulation therapy. Photobiomodul Photomed Laser Surg 2019;37:517-26. DOI: https://doi.org/10.1089/photob.2019.4684
Giuliani A, Lorenzini L, Gallamini M, et al. Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Complement Altern Med 2009;9:1-10. DOI: https://doi.org/10.1186/1472-6882-9-8
Espey BT, Kielwein K, van der Ven H, et al. Effects of pulsed‐wave photobiomodulation therapy on human spermatozoa. Lasers Surg Med 2022;54:540-53. DOI: https://doi.org/10.1002/lsm.23399
Osipov AN, Machneva TV, Buravlev EA, Vladimirov YA. Effects of laser radiation on mitochondria and mitochondrial proteins subjected to nitric oxide. Front Med (Lausanne) 2018;5:112. DOI: https://doi.org/10.3389/fmed.2018.00112
Ferraresi C, Kaippert B, Avci P, et al. Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3-6 h. Photochem Photobiol 2015;91:411-6. DOI: https://doi.org/10.1111/php.12397
How to Cite
Longevity concept by regenerative medicine methods synergy: exosome therapy, functional medicine, and advanced multi-wavelengths laser therapy. (2025). European Journal of Translational Myology, 35(2). https://doi.org/10.4081/ejtm.2025.13540
Copyright (c) 2025 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.