Efficacy and safety of Apixaban for the prevention of thrombosis in arteriovenous grafts


Submitted: 25 October 2023
Accepted: 5 December 2023
Published: 15 January 2024
Abstract Views: 499
PDF: 266
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Authors

  • Arash Hedayat Hematology Oncology Division, Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of.
  • Aidin Esrafilian Soltani Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Mahdi Hakiminezhad Department of General surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Fateme Zareian Department of Nursing, School of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran, Islamic Republic of.
  • Mandana Saneian Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of.
  • Mohamad Moradmand Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Sahand Abrishami Cardiovascular Research Center, Department of Cardiovascular Surgery, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Mohamad Hosein Tabatabaei Nodoushan Iran University of Medical Sciences, Faculty of Medicine, Shohadaye Salamat Hospital, Malard, Iran, Islamic Republic of.
  • Ali Pouriayevali Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of.
  • Mahdi Mohebbi Valiasr Hospital, Abadan University of Medical Sciences, Khoramshahr, Iran, Islamic Republic of.
  • Helia Ghorbani Department of Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.

This research aims to fill a vital gap in existing studies by evaluating the efficacy and safety of Apixaban, a direct oral anticoagulant, in the prevention of arteriovenous graft (AVG) thrombosis, thereby offering substantial insights into alternative anticoagulant options for hemodialysis patients. Conducted as a multi-center, randomized, double-blind, placebo-controlled trial, this study involved end-stage renal disease (ESRD) patients who had recently received polytetrafluoroethylene grafts. Participants were assigned to receive either Apixaban at a dose of 2.5 mg twice daily or a placebo. The primary outcome measure was the occurrence of graft thrombosis, while secondary outcomes focused on the incidence and severity of bleeding. Analytical methods included Kaplan-Meier estimates, Cox proportional hazards models, and conventional statistical tests. With 96 patients enrolled, the study found that Apixaban significantly reduced the incidence of AVG thrombosis compared to placebo (16.7% vs. 62.5%, P < 0.0001). Notably, this reduction in thrombosis incidence was not accompanied by an increase in bleeding events, thus affirming the safety profile of Apixaban as established in prior research. Apixaban is identified as an efficacious alternative to traditional anticoagulants in the prevention of AVG thrombosis among hemodialysis patients, representing a notable advancement in the care of individuals with ESRD. The results of this study support further investigations into the optimal dosing strategies specifically tailored for this patient demographic.


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