2023 Padua Days of Muscle and Mobility Medicine: post-meeting Book of Abstracts

Sandra Zampieri; Ines Bersch; Helmut Kern; Nejc Sarabon; Riccardo Rosati; Nathan K. LeBrasseur; Christiaan Leeuwenburg; Ugo Carraro

doi:10.4081/ejtm.2023.11427

Authors

Sandra Zampieri
sanzamp@unipd.it
Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy; Department of Biomedical Sciences, University of Padua, Italy; CIR MYO - Interdepartmental Research Centre of Myology, University of Padua, Italy; Armando & Carmela Mioni-Carraro Foundation for Translational Myology, Padua, Italy; Ludwig Boltzmann Institute for Rehabilitation Research, Wien, Austria; Centre of Active Ageing, Sankt Poelten , Austria.
Ines Bersch International FES Centre®, Swiss Paraplegic Centre, Nottwil, Switzerland.
Helmut Kern Ludwig Boltzmann Institute for Rehabilitation Research, Wien, Austria; Centre of Active Ageing, Sankt Poelten, Austria.
Nejc Sarabon University of Primorska, Faculty of Health Sciences, Izola, Slovenia; S2P, Science to Practice, Ltd., Laboratory for Motor Control and Motor Behaviour, Ljubljana, Slovenia; InnoRenew CoE, Izola, Slovenia.
Riccardo Rosati Department of Biomedical Surgical and Dental Sciences, University of Milan, Milan, Italy.
Nathan K. LeBrasseur Department of Physical Medicine and Rehabilitation, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Minnesota, United States.
Christiaan Leeuwenburg Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL, United States.
Ugo Carraro Department of Biomedical Sciences, University of Padua, Italy; CIR MYO - Interdepartmental Research Centre of Myology, University of Padua, Italy; Armando & Carmela Mioni-Carraro Foundation for Translational Myology, Padua, Italy. https://orcid.org/0000-0002-0924-4998

The 2023 Padua Days of Muscle and Mobility Medicine (Pdm₃) were held from March 29th to April 1st, 2023. Most of the abstracts were published electronically in the European Journal of Translational Myology (EJTM) 33 (1) 2023. Here we report the complete book of abstracts that confirms the interest of more than 150 scientists and clinicians from Austria, Bulgaria, Canada, Denmark, France, Georgia, Germany, Iceland, Ireland, Italy, Mongolia, Norway, Russia, Slovakia, Slovenia, Spain, Switzerland, The Netherlands and USA to gather to the Hotel Petrarca of Thermae of Euganean Hills, Padua, Italy for contributing and attending the Pdm₃ (https://www.youtube.com/watch?v=zC02D4uPWRg). The 2023 Pdm₃ started March 29th in the historic Aula Guariento of thePadua Galilean Academy of Letters, Arts and Sciences with the Lecture of Prof. Carlo Reggiani and ended in the late afternoon with the Lecture of Professor Terje Lømo after introductory words of Professor Stefano Schiaffino. The program followed in the Hotel Petrarca Conferenece Halls from March 30 to April 1, 2023. The extended topic interests of specialists in basic myology sciences and clinicians, collected under the umbrella neologism of Mobility Medicine, is stressed also by expansion of Sections of the EJTM Editorial Board (https://www.pagepressjournals.org/index.php/bam/board). We hope that Speakers of the 2023 Pdm₃ and readers of EJTM will submit “EJTM Communications” to the European Journal of Translational Myology (PAGEpress, Pavia, Italy) by May 31, 2023 and/or invited review and original articles for the 2023 special issue: "Pdm₃" of Diagnostics, MDPI, Basel, Switzerland due September 30, 2023.

Zampieri S, Narici MV, Gargiulo P, Carraro U. Abstracts of the 2023 Padua Days of Muscle and Mobility Medicine (2023Pdm3) to be held March 29 - April 1 at the Galileian Academy of Padua and at the Petrarca Hotel, Thermae of Euganean Hills, Padua, Italy. Eur J Transl Myol. 2023 Feb 10. Epub ahead of print. PMID: 36786151. DOI: https://doi.org/10.4081/ejtm.2023.11247

Zampieri S, Stecco C, Narici M, Masiero S, Carraro U. 2023 On-site Padua Days on Muscle and Mobiliy Medicine: Call for speakers. Eur J Transl Myol. 2022 Dec 13. Online ahead of print. PMID: 36511885 Free article. DOI: https://doi.org/10.4081/ejtm.2022.11071

Carraro U, Bittmann F, Ivanova E, Jónsson H Jr, Kern H, Leeuwenburgh C, Mayr W, Scalabrin M, Schaefer L, Smeriglio P, Zampieri S. Post-meeting report of the 2022 On-site Padua Days on Muscle and Mobility Medicine, March 30 - April 3, 2022, Padua, Italy. Eur J Transl Myol. 2022 Apr 13;32(2):10521. PMID: 35421919; PMCID: PMC9295170. DOI: https://doi.org/10.4081/ejtm.2022.10521

Sweeney HL, Masiero S, Carraro U. The 2022 On-site Padua Days on Muscle and Mobility Medicine hosts the University of Florida Institute of Myology and the Wellstone Center, March 30 - April 3, 2022 at the University of Padua and Thermae of Euganean Hills, Padua, Italy: The collection of abstracts. Eur J Transl Myol. 2022 Mar 10;32(1):10440. PMID: 35272451; PMCID: PMC8992680. DOI: https://doi.org/10.4081/ejtm.2022.10440

Carraro U, Yablonka-Reuveni Z. Translational research on Myology and Mobility Medicine: 2021 semi-virtual PDM3 from Thermae of Euganean Hills, May 26 - 29, 2021. Eur J Transl Myol. 2021 Mar 18;31(1):9743. PMID: 33733717; PMCID: PMC8056169. DOI: https://doi.org/10.4081/ejtm.2021.9743

Carraro U. Thirty years of translational research in Mobility Medicine: Collection of abstracts of the 2020 Padua Muscle Days. Eur J Transl Myol. 2020 Apr 1;30(1):8826. PMID: 32499887; PMCID: PMC7254447 DOI: https://doi.org/10.4081/ejtm.2019.8826

Carraro U. 2019Spring PaduaMuscleDays: Translational Myology and Mobility Medicine. Eur J Transl Myol. 2019 Feb 21;29(1):8105. PMID: 31019665; PMCID: PMC6460213 DOI: https://doi.org/10.4081/ejtm.2019.8105

Carraro U. Exciting perspectives for Translational Myology in the Abstracts of the 2018Spring PaduaMuscleDays: Giovanni Salviati Memorial - Chapter I - Foreword. Eur J Transl Myol. 2018 Feb 20;28(1):7363. PMID: 29686822; PMCID: PMC5895991. DOI: https://doi.org/10.4081/ejtm.2018.7363

Carraro U. 2017Spring PaduaMuscleDays, roots and byproducts. Eur J Transl Myol. 2017 Jun 27;27(2):6810. PMID: 28713538; PMCID: PMC5505085. DOI: https://doi.org/10.4081/ejtm.2017.6810

Ugo Carraro, Department of Biomedical Sciences, University of Padua, Italy; CIR MYO - Interdepartmental Research Centre of Myology, University of Padua, Italy; Armando & Carmela Mioni-Carraro Foundation for Translational Myology, Padua

CURRICULUM VITAE: Prof. UGO CARRARO

ORCID iD: https://orcid.org/0000-0002-0924-4998

Prof. Ugo Carraro, M.D.,

Senior Scholar of the University of Padova, Italy

Department of Biomedical Sciences, University of Padova, Italy

phone: +39 338 1575745

E-mail: ugo.carraro@unipd.it

Born: February 23, 1943, Abano Terme (Padova), Italy

Citizenship: Italy

Degree and Academic Positions

- M.D. (Laurea in Medicina e Chirurgia), University of Padua, Italy -1968

- Associate Professor of General Pathology, Faculty of Medicine, University of Padova,1983-2013

- Principal Investigator of the Laboratory of Applied Myology of the C.N.R Institute of Neuroscience, 1983-2000

- Acting-director of the Department of Biomedical Science -1998 to 2003;

- Principal Investigator of the Translational Myology Lab, Department of Biomedical Science -1998 to 2013

- Interdepartmental Research Center of Myology (cirMYO), Founder and Head 2005 - 2011

Other Professional Activities

- 1991-2019 – Founder and Editor-in-Chief of Basic Applied Myology: 1991 to date

- Consultant of I.R.C.C.S. Ospedale San Camillo di Venezia-Lido, Italy

- Referee for International Journals and Granting Agencies: J Cell Biol, Muscle&Nerve, Artificial Organs, J Muscle Res Cell Motility, Artificial Organs, Cell Death & Differentiation, Annals Thoracic Surgery, Acta Physiologica, The Open Rehabilitation Journal, Association Française contre les Myopathies

- Organizer of International Conferences and Courses

- Invited speaker and chairman in International Conferences

Main Research Interests

- Translational Myology: Basics of muscle plasticity and their applications to medical research, in particular:

Functional Electrical Stimulation (FES) of denervated human muscle
Role of regenerative myogenesis in exercise-induced muscle damage and denervation
Reconstruction, neurotization and artificial synaptogenesis of ablated skeletal muscle
Analyses in muscle atrophy and apoptosis of role of Cytokines and Myokines by invasive and non-invasive samplings

Achievments and expertises

Prof. Ugo Carraro is a world-class leader in molecular and structural analyses of skeletal muscle. He developed bi-dimensional gel electrophoresis for myosin light chains, in particular the embryonic isoform, and was the first to separate human myosin heavy chain isoforms.

He discovered the long-term potential of denervated muscle to survive denervation by non-compensatory myofiber regeneration.

Prof. Carraro was Associate Professor of General Pathology at the Faculty of Medicine of the University of Padova, from 1983 to 2013. Editor-in-Chief of The European Journal of Translational Myology since 1991, he founded and chaired from 2005 to 2011 Interdepartmental Research Center of Myology (CIR-Myo) of the University of Padova. CIR-Myo continue to join scientists and clinicians of the Departments of Biology, Biomedical Sciences, Neuroscience, Medicine and Surgical Sciences, Physical Medicine and Rehabilitation and Experimental & Clinical Veterinary Sciences.

In collaboration with international partners, in particular the Ludwig Boltzmann Institute of Electrostimulation and Physical Rehabilitation of the Wilheminenspital, Vienna, Austria, CIR-Myo scientists and clinicians developed and implemented the expertise and facilities to maintain and extend in Interreg IVa a world-unique BIO-BANK of human skeletal muscle biopsies harvested from upper motor neuron and lower motor neuron denervated patients and related animal research, young and senior sportsmen, healthy and diseased elderly persons before and during recovery by new therapies and rehabilitation strategies. In particular, muscle biopsies were harvested from patients affected with spinal cord injury and severe leg trauma, osteoarthropathies and rheumatic autoimmune diseases, and cancer.

CIR-Myo is developing also new imaging methods for functional monitoring of human skeletal muscles from patients suffering with permanent and transient muscle denervation. The collaboration with the Dr. Kern’s Vienna Group resulted in new knowledge and clinical validation of rehabilitation strategies for permanently denervated human muscles using home-based Functional Electrical Stimulation (FES). Thus, a world unique human muscle biopsies DATA-BASE of structural and molecular data obtained by histology, histo- and immuno-chemistry, electron microscopy and genomic/proteomic approaches is available to compare new rehabilitation strategies against standard clinical methods.

Carraro’s Lab matured expertises working on different aspects of muscle biology and pathology, including spinal cord injuries, aging, apoptosis, and muscle regeneration. This full set of methods and expertise are uniquely present at the CIR-Myo of Padova University, and well documented by a list of original results published in leading Journals of the different research fields.

Now Professor Carraro is validating NON-INVASIVE BLOOD ANALYSES to monitor Cytokines (anti- and pro- Inflammatory) and Myokines by saliva and sweat samplings, a very promising approach that will increase acceptability of sampling by volunteering persons and frequency of sampling, a key factor to evaluate the many very transient effects of trainings and rehabilitations in early aging and aging.

Publications

PUBMED April 12, 2020: Ugo Carraro 1973 - 2019 - References: 156 - Citations > 3000 –

h-index 44; h-index 37, excluding self-citations

List of 10 recent publications 2020-2016

Ricciardi C, Edmunds KJ, Recenti M, Sigurdsson S, Gudnason V, Carraro U, Gargiulo P. Assessing cardiovascular risks from a mid-thigh CT image: a tree-based machine learning approach using radiodensitometric distributions. Sci Rep. 2020 Feb 18;10(1):2863. doi: 10.1038/s41598-020-59873-9. PMID: 32071412
Carraro U. 2020PMD, 30-years of Translational Mobility Medicine at the time of COVID-19 outbreak: Last-minute forewords from the editor. Eur J Transl Myol 2020;30:8966. Doi 10.4081/ejtm.2019.8966.
Albertin G, Ravara B, Kern H, Hofer C, Loefler S, Jurecka W, Guidolin D, Rambaldo A, Porzionato A, De Caro R, Zampieri S, Pond A, Alaibac M, Carraro U. Two-years of home based functional electrical stimulation recovers epidermis from atrophy and flattening after years of complete Conus-Cauda Syndrome. Medicine (Baltimore). 2019 Dec;98(52):e18509. doi: 10.1097/MD.0000000000018509. PMID: 31876739.
Kern H, Gargiulo P, Pond A, Albertin G, Marcante A, Carraro U. To Reverse Atrophy of Human Muscles in Complete SCI Lower Motor Neuron Denervation by Home-Based Functional Electrical Stimulation. Adv Exp Med Biol. 2018;1088:585-591. doi: 10.1007/978-981-13-1435-3_27.
Carraro U, Gava K, Baba A, Marcante A, Piccione F. To Contrast and Reverse Skeletal Muscle Atrophy by Full-Body In-Bed Gym, a Mandatory Lifestyle for Older Olds and Borderline Mobility-Impaired Persons. Adv Exp Med Biol. 2018;1088:549-560. doi: 10.1007/978-981-13-1435-3_25. Review.
Carraro U. Exciting perspectives for Translational Myology in the Abstracts of the 2018Spring PaduaMuscleDays: Giovanni Salviati Memorial - Chapter I - Foreword. Eur J Transl Myol. 2018 Feb 20;28(1):7363. doi: 10.4081/ejtm.2018.7363. eCollection 2018 Jan 12.
Mosole S, Zampieri S, Furlan S, Carraro U, Löefler S, Kern H, Volpe P, Nori A. Effects of Electrical Stimulation on Skeletal Muscle of Old Sedentary People. Gerontol Geriatr Med. 2018 Apr 10;4:2333721418768998. doi: 10.1177/2333721418768998. eCollection 2018 Jan-Dec.
Edmunds K, Gíslason M, Sigurðsson S, Guðnason V, Harris T, Carraro U, Gargiulo P. Advanced quantitative methods in correlating sarcopenic muscle degeneration with lower extremity function biometrics and comorbidities. PLoS One. 2018 Mar 7;13(3):e0193241. doi: 10.1371/journal.pone.0193241. eCollection 2018.
Atrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Kern H, Hofer C, Loefler S, Zampieri S, Gargiulo P, Baba A, Marcante A, Piccione F, Pond A, Carraro U. Aging. Implications for their recovery by Functional Electrical Stimulation, updated 2017. Neurol Res. 2017 Jul;39(7):660-666. doi: 10.1080/01616412.2017.1314906. Epub 2017 Apr 13. Review.
Edmunds KJ, Árnadóttir Í, Gíslason MK, Carraro U, Gargiulo P. Nonlinear Trimodal Regression Analysis of Radiodensitometric Distributions to Quantify Sarcopenic and Sequelae Muscle Degeneration. Comput Math Methods Med. 2016;2016:8932950. doi: 10.1155/2016/8932950. Epub 2016 Dec 27.

Zampieri, S., Bersch, I., Kern, H., Sarabon, N., Rosati, R., LeBrasseur, N. K., Leeuwenburg, C., & Carraro, U. (2023). 2023 Padua Days of Muscle and Mobility Medicine: post-meeting Book of Abstracts. European Journal of Translational Myology, 33(2). https://doi.org/10.4081/ejtm.2023.11427