Relationship of vitamin D level with insulin dosage required based on insulin therapy protocol
https://doi.org/10.4081/ejtm.2023.11017
Accepted: 11 December 2022
HTML: 1
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
An Expression of Concern has been published | View
Update to April 27th, 2023: The Publisher is glad to inform the readers that the issue discussed in the Expression of Concern has been favorably resolved and we have no longer cause of concern regarding this paper.
The deficiency of vitamin D (VD) amongst Iranian people is high and also is related on hyperglycemia. This study aims to evaluate the association of VD levels with the required dose of insulin prescribed based on an insulin therapy protocol in critical condition patients admitted to intensive care unit (ICU), in an investigation based in Iran. This cross-sectional study was performed on patients who required insulin due to hyperglycemia. The relationship between serum VD level and the required dose of insulin prescribed based on insulin therapy protocol in this group of patients was investigated. A total of 172 patients with a mean age of 46.93 ± 31.9 years were included in this study. Across the included participants, 78.8% of patients had VD deficiency, 11.9% had insufficient VD and 9.3% had normal VD levels. There was a significant difference in mean blood sugar between the VD deficiency group and the normal group. VD levels were also significantly higher in men than women. Furthermore, the HbA1C hemoglobin level in patients with VD deficiency was significantly higher compared to the group with normal levels of VD. Our findings suggest that decreased VD is associated with increased blood sugar and insulin requirements in patients admitted to ICU. Women are at a higher risk for VD deficiency. We hope that these findings may help inform relevant treatment strategies.
Mazori AY, Bass IR, Chan L, Mathews KS, Altman DR, Saha A, Soh H, Wen HH, Bose S, Leven E, Wang JG, Mosoyan G, Pattharanitima P, Greco G, Gallagher EJ. Hyperglycemia is Associated With Increased Mortality in Critically Ill Patients With COVID-19. Endocr Pract. 2021 Feb;27(2):95-100. Epub 2021 Jan 9. PMID: 33551315; PMCID: PMC7796656. DOI: https://doi.org/10.1016/j.eprac.2020.12.015
Viana MV, Moraes RB, Fabbrin AR, Santos MF, Gerchman F. Avaliação e tratamento da hiperglicemia em pacientes graves [Assessment and treatment of hyperglycemia in critically ill patients]. Rev Bras Ter Intensiva. 2014 Jan-Mar;26(1):71-6. PMID: 24770692; PMCID: PMC4031893. DOI: https://doi.org/10.5935/0103-507X.20140011
Butler SO, Btaiche IF, Alaniz C. Relationship between hyperglycemia and infection in critically ill patients. Pharmacotherapy. 2005 Jul;25(7):963-76. PMID: 16006275. DOI: https://doi.org/10.1592/phco.2005.25.7.963
American Diabetes Association. Standards of medical care in diabetes--2013. Diabetes Care. 2013 Jan;36 Suppl 1(Suppl 1):S11-66. PMID: 23264422; PMCID: PMC3537269. DOI: https://doi.org/10.2337/dc13-S011
Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxy vitamin d and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care. 2010 Jun;33(6):1373-5. Epub 2010 Mar 23. PMID: 20332348; PMCID: PMC2875457. DOI: https://doi.org/10.2337/dc09-2199
Chowdhury TA, Boucher BJ, Hitman GA. Vitamin D and type 2 diabetes: Is there a link? Prim Care Diabetes. 2009 May;3(2):115-6. Epub 2009 Apr 23. PMID: 19395331. DOI: https://doi.org/10.1016/j.pcd.2009.03.004
Sobhani A, Heidarnezhad Z, Mansour ghanaei M, Salamat F. Association Between Vitamin D and Gestational Diabetes. J Guil Uni Med Sci 2016; 25 (98) :45-50.
Althaus J. Vitamin D and pregnancy: 9 things you need to know. OBG Management 2011; 23(8):30-8.
Moradzadeh K, Larijani B, Keshtkar A, Hossein Nezhad A, Rajabian R, Nabipoor I, et al . Normal values of Vitamin D and prevalence of Vitamin D deficiency among Iranian population. SJKU 2006; 10 (4) :22-42
World Health Organization. Global disease burden from solar ultraviolet radiation. 2006.
Karras SN, Wagner CL, Castracane VD. Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism. 2018 Sep;86:112-123. Epub 2017 Oct 21. PMID: 29066285. DOI: https://doi.org/10.1016/j.metabol.2017.10.001
von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr. 2010 Feb;103(4):549-55. Epub 2009 Sep 28. PMID: 19781131. DOI: https://doi.org/10.1017/S0007114509992017
Chesdachai S, Tangpricha V. Treatment of vitamin D deficiency in cystic fibrosis. J Steroid Biochem Mol Biol. 2016 Nov;164:36-39. Epub 2015 Sep 10. PMID: 26365559; PMCID: PMC4786457. DOI: https://doi.org/10.1016/j.jsbmb.2015.09.013
Bizzaro G, Antico A, Fortunato A, Bizzaro N. Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Isr Med Assoc J. 2017 Jul;19(7):438-443. PMID: 28786260.
Sheth JJ, Shah A, Sheth FJ, Trivedi S, Lele M, Shah N, Thakor P, Vaidya R. Does vitamin D play a significant role in type 2 diabetes? BMC Endocr Disord. 2015 Feb 26;15:5. PMID: 25887335; PMCID: PMC4357062. DOI: https://doi.org/10.1186/s12902-015-0003-8
Taheri E, Djalali M, Saedi- Someolia A, Jazayeri A, Rahimi A. The association of vitamin D and glycemic profiles in diabetic patients compared to healthy control. J Isfahan Med School 2011; 29: 952-964.
Djalali M, Taheri E, Saedisomeolia A, Djazayeri A, Rahemi A, Hashemi M, Larijani B. Vitamin D status of type 2 diabetic patients compared with healthy subjects in the Islamic Republic of Iran. East Mediterr Health J. 2014 Jan 9;19 Suppl 3:S6-S11. PMID: 24995761. DOI: https://doi.org/10.26719/2013.19.Supp3.S6
Al Zarooni AAR, Al Marzouqi FI, Al Darmaki SH, Prinsloo EAM, Nagelkerke N. Prevalence of vitamin D deficiency and associated comorbidities among Abu Dhabi Emirates population. BMC Res Notes. 2019 Aug 14;12(1):503. PMID: 31412921; PMCID: PMC6693241. DOI: https://doi.org/10.1186/s13104-019-4536-1
Baziar N, DJafarian K, Shadman Z, Qorbani M, Khoshniat Nikoo M, Razi F. Effect of vitamin d supplementation on improving vitamin d levels and insulin resistance in vitamin d insufficient or defficient type2 diabetics. ijdld 2014; 13 (5) :425-433.
McKinney JD, Bailey BA, Garrett LH, Peiris P, Manning T, Peiris AN. Relationship between vitamin D status and ICU outcomes in veterans. J Am Med Dir Assoc. 2011 Mar; 12(3):208-11. PMID: 21333923. DOI: https://doi.org/10.1016/j.jamda.2010.04.004
Arnson Y, Gringauz I, Itzhaky D, Amital H. Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients. QJM. 2012 Jul;105(7):633-9. Epub 2012 Feb 12. PMID: 22331959. DOI: https://doi.org/10.1093/qjmed/hcs014
Ozfirat Z, Chowdhury TA. Vitamin D deficiency and type 2 diabetes. Postgrad Med J. 2010 Jan;86(1011):18-25; quiz 24. PMID: 20065337. DOI: https://doi.org/10.1136/pgmj.2009.078626
Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004 May;79(5):820-5. PMID: 15113720. DOI: https://doi.org/10.1093/ajcn/79.5.820
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
