https://doi.org/10.4081/aiua.2022.1.123
Aristolochic acid: What urologists should know
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 30 March 2022
To the Editor,
Aristolochic acid is one of major causes for upper tract urothelial carcinoma, especially in younger population. While it is mentioned as a cause in guidelines, little is actually known about the toxin by urologists. We are aiming in our letter to provide some direct and clear information to ourselves that would help us to know more about that toxin and how it can adversely affect our patients [...].
Downloads
Luciano RL, Perazella MA. Aristolochic acid nephropathy: epidemiology, clinical presentation, and treatment. Drug Saf. 2015; 38:55-64. DOI: https://doi.org/10.1007/s40264-014-0244-x
Jelakovic B, Dika Ž, Arlt VM, et al. Balkan endemic nephropathy and the causative role of aristolochic acid. Semin Nephrol. 2019; 39:284-296. DOI: https://doi.org/10.1016/j.semnephrol.2019.02.007
Rouprêt M, Babjuk M, Burger M, et al. European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update. Eur Urol. 2021; 79:62-79. DOI: https://doi.org/10.1016/j.eururo.2020.05.042
Zhong W, Zhang L, Ma J, et al. Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy. Onco Targets Ther. 2017; 10:5775-5782. DOI: https://doi.org/10.2147/OTT.S148641
Kang YC, Chen MH, Lin CY, et al. Aristolochic acid-associated urinary tract cancers: an updated meta-analysis of risk and oncologic outcomes after surgery and systematic review of molecular alterations observed in human studies. Ther Adv Drug Saf. 2021; 12:2042098621997727 DOI: https://doi.org/10.1177/2042098621997727
http://wayback.archive-it.org/7993/20171114232638/https://www.fda.gov/Food/RecallsOutbreaksEmergencies/SafetyAlertsAdvisories/ ucm095272.htm. Accessed online on December 29, 2021.
https://www.canada.ca/en/news/archive/2004/07/health-canada-advises-consumers-not-use-products-containing-aristolochic-acid.html. Accessed online on December 29, 2021.
Chan CK, Liu Y, Pavlovic NM, Chan W. Aristolochic acids: newly identified exposure pathways of this class of environmental and food-borne contaminants and its potential link to chronic kidney diseases. Toxics. 2019; 7:14. DOI: https://doi.org/10.3390/toxics7010014
Li W, Chan CK, Liu Y, et al. Aristolochic acids as persistent soil pollutants: determination of risk for human exposure and nephropathy from plant uptake. J Agric Food Chem. 2018; 66:11468-11476. DOI: https://doi.org/10.1021/acs.jafc.8b04770
Chan W, Pavlovic NM, Li W, et al. Quantitation of aristolochic acids in corn, wheat grain, and soil samples collected in Serbia: identifying a novel exposure pathway in the etiology of Balkan endemic nephropathy. J Agric Food Chem. 2016; 64:5928-34. DOI: https://doi.org/10.1021/acs.jafc.6b02203
Au CK, Zhang J, Chan CK, et al. Determination of aristolochic acids in vegetables: nephrotoxic and carcinogenic environmental pollutants contaminating a broad swath of the food supply and driving incidence of Balkan endemic nephropathy. Chem Res Toxicol. 2020; 33:2446-2454. DOI: https://doi.org/10.1021/acs.chemrestox.0c00229
Draghia LP, Lukinich-Gruia AT, Oprean C, et al. Aristolochic acid I: an investigation into the role of food crops contamination, as a potential natural exposure pathway. Environ Geochem Health. 2021; 43:4163-4178. DOI: https://doi.org/10.1007/s10653-021-00903-4
Abdullah R, Diaz LN, Wesseling S, Rietjens IM. Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017; 34:135-144. DOI: https://doi.org/10.1080/19440049.2016.1266098
https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono100A-23.pdf. Accessed online on January 17, 2022.
https://www.accessdata.fda.gov/cms_ia/importalert_141.html. Accessed online on January 18, 2022.
Dechbumroong P, Aumnouypol S, Denduangboripant J, Sukrong S. DNA barcoding of Aristolochia plants and development of species-specific multiplex PCR to aid HPTLC in ascertainment of Aristolochia herbal materials. PLoS One. 2018; 13:e0202625. DOI: https://doi.org/10.1371/journal.pone.0202625
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.