Early morning kidney transplantation: Perioperative complications


Submitted: January 9, 2021
Accepted: February 23, 2021
Published: June 28, 2021
Abstract Views: 906
PDF: 357
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Authors

  • Mário Pereira Lourenço Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Miguel Eliseu Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Duarte Vieira Brito Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • João Carvalho Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Edgar Tavares-Silva Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Lorenzo Marconi Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Pedro Moreira Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Pedro Nunes Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Belmiro Parada Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Carlos Bastos Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.
  • Arnaldo Figueiredo Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra, Portugal.

Introduction: To reduce cold ischemia time (CIT), many kidney transplants are performed in the early morning. Conducting complex surgeries in the early morning may influence the surgeon's technical capacity and rate of surgical complications (SC). Aim: Evaluate the influence of surgery start hour (SSH) regarding duration of surgery (DS), immediate diuresis (ID), SC and acute rejection (AR); evaluate the influence of CIT regarding SC, ID, and AR.
Methods: 2855 cadaveric transplants performed between June 1980 and March 2018 were retrospectively evaluated. Regarding SSH, two groups were created: Group M (00: 00h-05.59h, n = 253) and Group D (06: 00h - 23: 59h, n = 2602). Analyzing the impact of SSH on DS, ID, SC and AR. Evaluate the relationship between CIT (< 18h, 18-30h and > 30h) on ID, SC and AR utilizing univariate and multivariate statistical analysis with SPSS.
Results and Conclusion: Groups M and D were comparable in all evaluated demographic variables (p > 0.05), except cold ischemia time (Group M with higher CIT, p < 0.001). Regarding univariate analysis, Surgery start hour did not influence DS (p = 0.344), and SC (p = 0.264), but related with higher ID (p = 0.028) and AR (p = 0.018). CIT related with immediate diuresis (p = 0.020) and acute rejection (p < 0.001) but did not relate with complications (p = 0.734). Regarding multivariate analysis, SSH only influenced immediate diuresis (p = 0.026) and did not influenced acute rejection (p = 0.055). CIT influenced immediate diuresis (p = 0.019) and acute rejection (p < 0.001). Surgery start hour influences Immediate diuresis. With this study, we conclude that the priority must be a short cold ischemia time.


Kohn L. To err is human: an interview with the Institute of Medicine's Linda Kohn. Jt Comm J Qual Improv. 2000; 26:227-34. DOI: https://doi.org/10.1016/S1070-3241(00)26017-3

Gaba DM, Howard SK. Patient safety: fatigue among clinicians and the safety of patients. N Engl J Med. 2002; 347:1249-55. DOI: https://doi.org/10.1056/NEJMsa020846

Borman KR, Fuhrman GM; Association Program Directors in Surgery. "Resident Duty Hours: Enhancing Sleep, Supervision, and Safety": response of the Association of Program Directors in Surgery to the December 2008 Report of the Institute of Medicine. Surgery 2009; 146:420-7. DOI: https://doi.org/10.1016/j.surg.2009.06.023

Chen CL, Chen Y Sen, Liu PP, et al. Living related donor liver transplantation. J Gastroenterol Hepatol. 1997; 12: S342-345. DOI: https://doi.org/10.1111/j.1440-1746.1997.tb00519.x

Rothschild JM, Keohane CA, Rogers S, et al. Risks of complications by attending physicians after performing nighttime procedures. JAMA. 2009; 302:1565-72. DOI: https://doi.org/10.1001/jama.2009.1423

Gray A. United Kingdom national confidential enquiry into perioperative deaths. Minerva Anestesiol. 2000; 66:288-92.

Fechner G, Pezold C, Hauser S, et al. Kidney's nightshift, kidney's nightmare? Comparison of daylight and nighttime kidney transplantation: impact on complications and graft survival. Transplant Proc. 2008; 40:1341-4. DOI: https://doi.org/10.1016/j.transproceed.2008.02.072

Debout A, Foucher Y, Trébern-Launay K, et al. Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal transplantation. Kidney Int. 2015; 87:343-9. DOI: https://doi.org/10.1038/ki.2014.304

van Roijen JH, Kirkels WJ, Zietse R, et al. Long-term graft survival after urological complications of 695 kidney transplantations. J Urol. 2001; 165:1884-7. DOI: https://doi.org/10.1097/00005392-200106000-00010

Opelz G, Döhler B. Multicenter analysis of kidney preservation. Transplantation. 2007; 83:247-53. DOI: https://doi.org/10.1097/01.tp.0000251781.36117.27

Król R, Ziaja J, Chudek J, Heitzman M, et al. Surgical treatment of urological complications after kidney transplantation. Transplant Proc. 2006;38:127-30. DOI: https://doi.org/10.1016/j.transproceed.2005.12.100

Agüera Fernandez LG, Robles JE, Rosell D, et al. Análisis multivariado del impacto de las complicaciones quirúrgicas en el trasplante renal (Multivariate analysis of the impact of surgical complications in renal transplant). Arch Esp Urol. 1994; 47:999-1006.

Seow YY, Alkari B, Dyer P, Riad H. Cold ischemia time, surgeon, time of day, and surgical complications. Transplantation. 2004; 77:1386-9. DOI: https://doi.org/10.1097/01.TP.0000122230.46091.E2

Kienzl-Wagner K, Schneiderbauer S, Bösmüller C, et al. Nighttime procedures are not associated with adverse outcomes in kidney transplantation. Transpl Int. 2013; 26:879-85. DOI: https://doi.org/10.1111/tri.12125

Shaw TM, Lonze BE, Feyssa EL, et al. Operative start times and complications after kidney transplantation. Clin Transplant. 2012; 26:E177-83. DOI: https://doi.org/10.1111/j.1399-0012.2012.1622.x

Emmanouilidis N, Boeckler J, Ringe BP, et al. Risk balancing of cold ischemic time against night shift surgery possibly reduces rates of reoperation and perioperative graft loss. J Transplant. 2017; 2017:5362704. DOI: https://doi.org/10.1155/2017/5362704

Gopalakrishnan G, Gourabathini SP. Marginal kidney donor. Indian J Urol. 2007; 23:286-93. DOI: https://doi.org/10.4103/0970-1591.33726

Chapman JR. Marginal kidneys for transplantation. BMJ 2015; 351:h3856. DOI: https://doi.org/10.1136/bmj.h3856

Amirian I. The impact of sleep deprivation on surgeons' performance during night shifts. Dan Med J. 2014; 61:B4912.

Moreira P, Sá H, Figueiredo A, Mota A. Delayed renal graft function: risk factors and impact on the outcome of transplantation. Transplant Proc. 2011; 43:100-5. DOI: https://doi.org/10.1016/j.transproceed.2010.12.023

Salahudeen AK, Haider N, May W. Cold ischemia and the reduced long-term survival of cadaveric renal allografts. Kidney Int. 2004; 65:713-8. DOI: https://doi.org/10.1111/j.1523-1755.2004.00416.x

Hernández D, Estupiñán S, Pérez G, et al. Impact of cold ischemia time on renal allograft outcome using kidneys from young donors. Transpl Int. 2008; 21:955-62 DOI: https://doi.org/10.1111/j.1432-2277.2008.00708.x

Lonze BE, Parsikia A, Feyssa EL, et al. Operative start times and complications after liver transplantation. Am J Transplant. 2010; 10:1842-9. DOI: https://doi.org/10.1111/j.1600-6143.2010.03177.x

George TJ, Arnaoutakis GJ, Merlo CA, et al. Association of operative time of day with outcomes after thoracic organ transplant. JAMA. 2011; 305:2193-9. DOI: https://doi.org/10.1001/jama.2011.726

Araujo RL, Karkar AM, Allen PJ, et al. Timing of elective surgery as a perioperative outcome variable: analysis of pancreaticoduodenectomy. HPB (Oxford). 2014; 16:250-62. DOI: https://doi.org/10.1111/hpb.12107

Heller JA, Kothari R, Lin HM, et al. Surgery start time does not impact outcome in elective cardiac surgery. J Cardiothorac Vasc Anesth. 2017; 31:32-36. DOI: https://doi.org/10.1053/j.jvca.2016.08.015

Zafar SN, Libuit L, Hashmi ZG, et al. The sleepy surgeon: does night-time surgery for trauma affect mortality outcomes? Am J Surg. 2015; 209:633-9. DOI: https://doi.org/10.1016/j.amjsurg.2014.12.015

Dalton MK, McDonald E, Bhatia P, et al. Outcomes of acute care surgical cases performed at night. Am J Surg. 2016; 212:831-836. DOI: https://doi.org/10.1016/j.amjsurg.2016.02.024

Pereira Lourenço, M. ., Eliseu, M. ., Brito, D. V., Carvalho, J., Tavares-Silva, E., Marconi, L., Moreira, P. ., Nunes, P., Parada, B., Bastos, C., & Figueiredo, A. (2021). Early morning kidney transplantation: Perioperative complications. Archivio Italiano Di Urologia E Andrologia, 93(2), 158–161. https://doi.org/10.4081/aiua.2021.2.158

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