The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy

Submitted: September 28, 2015
Accepted: September 28, 2015
Published: September 30, 2015
Abstract Views: 1528
PDF: 778
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Objective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Hazar, A. I., Cakiroglu, B., Sakalli, E., Balci, M. B. C., Eyyupoglu, E., Tas, T., Sinanoglu, O., Tuzlali, P., & Cilesiz, N. C. (2015). The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy. Archivio Italiano Di Urologia E Andrologia, 87(3), 198–203. https://doi.org/10.4081/aiua.2015.3.198