https://doi.org/10.4081/aiua.2026.14900
Transition learning curve of a single surgeon performing ultrasound-guided modified lateral position percutaneous nephrolithotomy
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 3 March 2026
Background: Ultrasound-guided percutaneous nephrolithotomy (PCNL) performed in the modified lateral position offers advantages in ergonomics, airway control, and radiation reduction. However, evidence describing the transition learning curve of surgeons previously trained in fluoroscopy-guided prone PCNL remains limited. This study evaluates learning progression, surgical efficiency, and safety outcomes as an experienced fluoroscopic surgeon adopts an ultrasound-guided modified lateral PCNL technique.
Materials and methods: This retrospective study included 70 consecutive patients who underwent ultrasound-guided modified lateral PCNL with extended legs, performed by a single surgeon experienced in fluoroscopy-guided prone PCNL. Patients were divided chronologically into three groups (cases 1-25, 26-50, and 51-70). Operative parameters, puncture characteristics, fluoroscopy time, stone-free rate (SFR), and complications were analyzed. Learning progression was assessed using cumulative summation (CUSUM) analysis based on operative time.
Results: Progressive improvements in performance were observed across the series. The proportion of single-attempt punctures increased from 40% to 75% (p=0.023), while upper calyceal access increased from 8% to 70% (p<0.001). Median operative, puncture, and fluoroscopy times all decreased significantly across the series. The overall SFR was 95.7%, increasing to 100% in the final group, with predominantly minor complications and no transfusion events. CUSUM analysis demonstrated a proficiency plateau at approximately 40 cases.
Conclusions: Surgeons experienced in fluoroscopy-guided prone PCNL can achieve proficiency in ultrasound-guided modified lateral PCNL after approximately 40 cases, with improved efficiency, enhanced puncture precision, and reduced radiation exposure, without compromising safety or stone-free outcomes.
Downloads
1. Skolarikos A, Jung H, Neisius A, et al. EAU guidelines on urolithiasis. EAU Guidelines. 2025.
2. Assimos D, Krambeck A, Miller NL, et al. Surgical management of stones: American Urological Association/Endourological Society guideline, part I. J Urol. 2016; 196:1153-1160. DOI: https://doi.org/10.1016/j.juro.2016.05.090
3. Zhao Z, Fan J, Liu Y, et al. Percutaneous nephrolithotomy: position, position, position! Urolithiasis. 2018; 46:79-86. DOI: https://doi.org/10.1007/s00240-017-1019-5
4. Ghani KR, Andonian S, Bultitude M, et al. Percutaneous nephrolithotomy: Update, Trends, and Future directions. Eur Urol. 2016; 70:382-396. DOI: https://doi.org/10.1016/j.eururo.2016.01.047
5. Patel SR, Nakada SY. The modern history and evolution of percutaneous nephrolithotomy. J Endourol. 2014; 29:153-157. DOI: https://doi.org/10.1089/end.2014.0287
6. Tzelves L, Geraghty RM, Hughes T, et al. Innovations in kidney stone removal. Res Rep Urol. 2023; 15:131-139. DOI: https://doi.org/10.2147/RRU.S386844
7. Song Y, Ma Y, Song Y, Fei X. Evaluating the learning curve for percutaneous nephrolithotomy under total ultrasound guidance. PLoS One. 2015;10:e0132986. DOI: https://doi.org/10.1371/journal.pone.0132986
8. Lu Z, Yang W, He W. Learning curve of ultrasound-guided percutaneous nephrolithotripsy in the treatment of complex renal calculi. J Int Med Res. 2024;52:3000605241239026. DOI: https://doi.org/10.1177/03000605241239026
9. Ng CF. Training in percutaneous nephrolithotomy: the learning curve and options. Arab J Urol. 2014; 12:54-57. DOI: https://doi.org/10.1016/j.aju.2013.08.002
10. de la Rosette JJMCH, Laguna MP, Rassweiler JJ, Conort P. Training in percutaneous nephrolithotomy—a critical review. Eur Urol. 2008; 54:994-1003. DOI: https://doi.org/10.1016/j.eururo.2008.03.052
11. Usawachintachit M, Masic S, Allen IE, et al. Adopting ultrasound guidance for prone percutaneous nephrolithotomy: evaluating the learning curve for the experienced surgeon. J Endourol. 2016; 30:856-863. DOI: https://doi.org/10.1089/end.2016.0241
12. Zoeir A, Mamdoh H, Moussa A, et al. Which is easier for beginners: supine or prone position percutaneous nephrolithotomy? Assessment of the learning curve in novice urologists through a randomized clinical trial. Minerva Urol Nephrol 2024;76:748-758. DOI: https://doi.org/10.23736/S2724-6051.24.05974-3
13. Haam JH, Kim BT, Kim EM, et al. Diagnosis of obesity: 2022 update of clinical practice guidelines for obesity by the Korean Society for the Study of Obesity. J Obes Metab Syndr. 2023; 32:121-129. DOI: https://doi.org/10.7570/jomes23031
14. Ito H, Kawahara T, Terao H, et al. The most reliable preoperative assessment of renal stone burden as a predictor of stone-free status after flexible ureteroscopy with holmium laser lithotripsy: a single-center experience. Urology. 2012; 80:524-528. DOI: https://doi.org/10.1016/j.urology.2012.04.001
15. Çavdar OF, Aydin A, Tokas T, et al. Residual stone fragments: systematic review of definitions, diagnostic standards. World J Urol. 2025; 43:194. DOI: https://doi.org/10.1007/s00345-025-05572-x
16. Sharma K, Sankhwar SN, Singh V, et al. Evaluation of factors predicting clinical pleural injury during percutaneous nephrolithotomy: a prospective study. Urolithiasis. 2016; 44:263-270. DOI: https://doi.org/10.1007/s00240-015-0820-2
17. Gargani L, Volpicelli G. How I do it: lung ultrasound. Cardiovasc Ultrasound 2014;12:25. DOI: https://doi.org/10.1186/1476-7120-12-25
18. Tanriverdi O, Boylu U, Kendirci M, et al. The learning curve in the training of percutaneous nephrolithotomy. Eur Urol. 2007;52:206-212. DOI: https://doi.org/10.1016/j.eururo.2007.01.001
19. Jang WS, Choi KH, Yang SC, Han WK. The learning curve for flank percutaneous nephrolithotomy for kidney calculi: a single surgeon’sexperience. Korean J Urol. 2011; 52:284-288. DOI: https://doi.org/10.4111/kju.2011.52.4.284
20. Mak DKC, Smith Y, Buchholz N, El-Husseiny T. What is better in percutaneous nephrolithotomy - prone or supine? A systematic review. Arab J Urol. 2016; 14:101-107. DOI: https://doi.org/10.1016/j.aju.2016.01.005
21. Cracco CM, Scoffone CM. Endoscopic combined intrarenal surgery (ECIRS) - tips and tricks to improve outcomes: a systematic review. Turk J Urol. 2020;46:S46-S57. DOI: https://doi.org/10.5152/tud.2020.20282
22. Bulut EC, Aydın U, Coskun Ç, et al. Which position for novice surgeons? Effect of supine and prone positions on percutaneous nephrolithotomy learning curve. Medicina (Kaunas). 2024;60:1292. DOI: https://doi.org/10.3390/medicina60081292
23. Arabzadeh Bahri R, Maleki S, Shafiee A, Shobeiri P. Ultrasound versus fluoroscopy as imaging guidance for percutaneous nephrolithotomy: a systematic review and meta-analysis. PLoS One 2023;18:e0276708. DOI: https://doi.org/10.1371/journal.pone.0276708
24. Wirtzfeld N, Keller EX, Kwok JL, et al. Systematic review on the learning curve of percutaneous nephrolithotomy: operative time, fluoroscopytime, stone-free rate, puncture performance, complications, and safety indicators. Urology 2025;205:271-89. DOI: https://doi.org/10.1016/j.urology.2025.05.060
Ethics Approval
this study was approved by the Institutional Ethics Committee (Approval No. 98/HĐĐĐ).CRediT authorship contribution
Ngoc Thai Nguyen, participation in research design, research perfomance, data acquisition, writing – original drafting, contribution to surgical and technical data interpretation. Shinnosuke Kuroda, participation in research design, data interpretation, writing – original drafting, writing – review & editing. Trong Nhan Tran, participation research perfomance, data collection, data analysis, writing – original drafting. Thanh Vu Phung, participation in research design, performance of the research, data analysis, writing – original drafting. Huynh Dang Khoa Nguyen, participation in research design, supervision of the study, data interpretation, writing – original drafting, final approval of the manuscript. All authors reviewed the manuscript, and agree to take public responsibility for its content.
Data Availability Statement
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
How to Cite

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.