https://doi.org/10.4081/aiua.2026.14737
Extracorporeal shock wave therapy (ESWT) in the treatment of Peyronie's disease: our initial experience
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Published: 2 March 2026
Background: Peyronie’s disease (PD) is a connective tissue disorder of the penis that causes pain, curvature, and erectile dysfunction.
Methods: A prospective study was conducted on 112 patients treated with ESWT. Each received three sessions of 3,000 shockwaves at 0.11-0.17 mJ/mm2. Pain, curvature, and erectile function were assessed.
Results: Pain relief occurred in 90% of patients (mean VAS reduction: 3, p<0.00001); 57.1% had curvature improvement (mean 30°, p<0.001); 26.2% of ED patients improved ≥ 4 points in IIEF.
Conclusions: ESWT appears safe and effective in improving pain and curvature in PD patients.
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1. Ziegelmann MJ, Bajic P, Levine LA. Peyronie’s disease: Contemporary evaluation and management. Int J Urol. 2020; 27:504-516. DOI: https://doi.org/10.1111/iju.14230
2. Hricz N, Schlidt K, Ha M, et al. A review of Peyronie's disease insurance coverage. Sex Med. 2024;12:qfae071. DOI: https://doi.org/10.1093/sexmed/qfae071
3. Moreland RB, Nehra A. Pathophysiology of Peyronie's disease. Int J Impot Res. 2002; 14:406-10. DOI: https://doi.org/10.1038/sj.ijir.3900875
4. Terrier JE, Nelson CJ. Psychological aspects of Peyronie’s disease. Transl Androl Urol. 2016; 5:290-295. DOI: https://doi.org/10.21037/tau.2016.05.14
5. Krieger JR, Rizk PJ, Kohn TP, Pastuszak A. Shockwave therapy in the treatment of Peyronie's disease. Sex Med Rev. 2019; 7:499-507. DOI: https://doi.org/10.1016/j.sxmr.2019.02.001
6. Chung PH, Han TM, Rudnik B, Das AK. Peyronie's disease: what do we know and how do we treat it? Can J Urol. 2020; 27:11-19.
7. Maiti K, Srivastava SK, Pal DK. Low-intensity extracorporeal shockwave therapy for Peyronie's disease: An Indian experience. Indian J Urol. 2023; 39:209-215. DOI: https://doi.org/10.4103/iju.iju_22_23
8. Palmieri A, Imbimbo C, Longo N, et al. A first prospective, randomized, double-blind, placebo-controlled clinical trial evaluating extracorporeal shock wave therapy for the treatment of Peyronie's disease. Eur Urol. 2009; 56:363-370. DOI: https://doi.org/10.1016/j.eururo.2009.05.012
9. Hauck EW, Altinkilic BM, Ludwig M, et al. Extracorporeal shock wave therapy in the treatment of Peyronie’s disease: First results of a case-controlled approach. Eur Urol. 2000; 38:663-670. DOI: https://doi.org/10.1159/000020359
10. Hayat S, Brunckhorst O, Alnajjar HM, et al. A systematic review of non-surgical management in Peyronie's disease. Int J Impot Res. 2023; 35:523-532. DOI: https://doi.org/10.1038/s41443-022-00633-w
11. Devine CJ, Horton CE. Surgical treatment of Peyronie's disease with a dermal graft. J Urol. 1974; 111:44-49. DOI: https://doi.org/10.1016/S0022-5347(17)59886-9
12. Husain J, Lynn NN, Jones DK, et al. Extracorporeal shock wave therapy in the management of Peyronie’s disease: initial experience. BJU Int. 2000; 86:466-468. DOI: https://doi.org/10.1046/j.1464-410X.2000.00827.x
13. Hauck EW, Mueller UO, Bschleipfer T, et al. Extracorporeal shock wave therapy for Peyronie’s disease: exploratory meta-analysis of clinical trials. J Urol. 2004;171:740-745. DOI: https://doi.org/10.1097/01.ju.0000108060.30363.8d
14. Rebillard X, Peyronnet B, Boujenah J, et al. Extracorporeal shockwave therapy in Peyronie’s disease: A systematic review and meta-analysis. World J Mens Health. 2019; 37:50-60.
15. Hatzichristodoulou G, Meisner C, Gschwend JE, et al. Extracorporeal shock wave therapy in Peyronie’s disease: results of a placebo-controlled, prospective, randomized, single-blind study. J Sex Med.2013; 10:2815-2821. DOI: https://doi.org/10.1111/jsm.12275
16. Bakr AM, El-Sakka AI. Extracorporeal shockwave therapy in Peyronie’s disease: systematic review and meta-analysis. J Sex Med. 2021; 18:1705-1714. DOI: https://doi.org/10.1016/j.jsxm.2021.06.012
17. Wang X, Liu H, Tang G, et al. Updated recommendations on the therapeutic role of extracorporeal shock wave therapy for Peyronie’s disease: systematic review and meta-analysis. BMC Urol. 2023;23:145. DOI: https://doi.org/10.1186/s12894-023-01320-8
18. Li G, Xu X, Man L. Low-intensity extracorporeal shock wave therapy for Peyronie's disease: A systematic review and meta-analysis. BMC Urol. 2024; 24:217. DOI: https://doi.org/10.1186/s12894-024-01607-4
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