https://doi.org/10.4081/aiua.2025.14296
Diode laser enucleation prostate for benign prostatic hyperplasia: outcomes of the Leonardi ejaculation sparing technique
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Published: 11 September 2025
Introduction: Benign prostatic hyperplasia (BPH) significantly impairs quality of life and may lead to complications such as urinary retention and recurrent infections. While endoscopic enucleation techniques provide effective relief, they are frequently associated with loss of antegrade ejaculation. The Leonardi Ejaculation-Sparing Technique (LEST) was developed to preserve ejaculatory function during diode laser enucleation of the prostate (DILEP).
Methods: We conducted an observational, retrospective analysis of 99 men undergoing DILEP with LEST between January 2018 and June 2020. Inclusion criteria were symptomatic BPH refractory to medical therapy, prostate volume ≥40 mL, and suitability for endoscopic surgery. Functional outcomes (IPSS, Qmax, PVR), erectile function (IIEF-5), and ejaculatory status (MSHQEjD) were assessed preoperatively and at 6 months. Patient satisfaction was evaluated with a dedicated 5-item questionnaire.
Results: Mean age was 48.1 years, and median prostate volume was 67 mL. At 6 months, IPSS decreased from 21.6 to 3.8, Qmax improved from 9.1 to 25.7 mL/s, and PVR decreased from 103 to 6.8 mL (all p<0.01). Erectile function showed modest improvement (IIEF-5: 14.4 to 16.2; p<0.01). Antegrade ejaculation was preserved in 94.1% of patients. Satisfaction was high, with > 80% willing to repeat the procedure and denying regret. No major complications occurred.
Conclusions: DILEP with LEST provides excellent functional results with high rates of ejaculatory preservation and patient satisfaction. This technique may represent a patient-centered alternative for BPH surgery, especially in younger men prioritizing sexual function.
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