https://doi.org/10.4081/aiua.2025.14249
Prevalence of erectile dysfunction and relationship between high sensitivity C-reactive protein, albuminuria, and cardiovascular risk factors with erectile dysfunction in coronary artery disease patients
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Published: 22 October 2025
Introduction: It is estimated that more than 150 million men worldwide have erectile dysfunction (ED) and this number will reach more than 300 million by 2025. There is strong evidence that ED increases the risk of future cardiovascular events. ED and CAD share common risk factors. High sensitivity C-Reactive Protein (hs-CRP) is an important inflammatory biomarker in subclinical atherosclerosis. Albuminuria is also a marker of widespread endothelial dysfunction and is thought to be associated with ED. This study was conducted to analyze the prevalence of ED and the relationship between hs-CRP, albuminuria, and cardiovascular risk factors with the occurrence of ED in CAD patients.
Materials and methods: From July 2024 to October 2024, 288 CAD cases from Saiful Anwar general hospital heart clinic met the inclusion criteria. Data on hs-CRP, albuminuria, and cardiovascular risk factors such as age, hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking were observed in relation to incidence of erectile dysfunction in CAD patients. Then logistic regression analysis was performed.
Results: There were 255 CAD patients (88.5%) who experienced ED. There was no significant relationship between hs-CRP and albuminuria with ED in CAD patients (p>0.05). Significant risk factors for ED in CAD patients were age (OR = 15.92; 95% CI = 4.67-54.22; p=0.000), triglycerides (OR = 2.52; 95% CI = 1.12-5.66; p=0.024), and smoking (OR = 0.29; 95% CI = 0.09-0.89; p=0.031).
Conclusions: The prevalence of erectile dysfunction was 88.5% in patients with coronary artery disease. Hs-CRP and albuminuria did not have a significant relationship with the incidence of ED in patients with CAD. Risk factors that independently affect incidence of ED in patients with CAD are age, smoking, and hypertriglyceridemia.
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1. Rinkuniene E, Gimžauskaite S, Badariene J, et al. The prevalence of erectile dysfunction and its association with cardiovascular risk factors in patients after myocardial infarction. Medicina (Kaunas). 2021;57:1103. DOI: https://doi.org/10.3390/medicina57101103
2. Salonia A, Bettocchi C, Capogrosso P, et al. EAU guidelines on sexual and reproductive health. Milan. 2023; pp.10-13.
3. Shigehara K, Konaka H, Ijima M, et al. The correlation between highly sensitive C-reactive protein levels and erectile function among men with late-onset hypogonadism. Aging Male (Kazuyoshi) 2023;19:239-43. DOI: https://doi.org/10.1080/13685538.2016.1233960
4. Barzilay JI, Farag YMK, Durthaler J. Albuminuria: An underappreciated risk factor for cardiovascular disease. J Am Heart Assoc. 2024; 3:e030131. DOI: https://doi.org/10.1161/JAHA.123.030131
5. Biernikiewicz M, Sobieszcza´nska M, Szuster E, et al. Erectile dysfunction as an obesity-related condition in elderly men with coronary artery disease. J Clin Med 2024;13:2087. DOI: https://doi.org/10.3390/jcm13072087
6. ZiabakhshTabary S, Mokhtari-Esbuie F, Fazli M. Evaluations of erectile dysfunction before and after on-pump coronary artery bypass graft surgery. Caspian J Intern Med 2014;5:209.
7. Eardley I. The incidence, prevalence, and natural history of erectile dysfunction. Sex Med Rev. 2013;1:3-16. DOI: https://doi.org/10.1002/smrj.2
8. Ferrini MG, Gonzalez-Cadavid NF, Rajfer J. Aging related erectile dysfunction—potential mechanism to halt or delay its onset. Transl Androl Urol. 2017; 6:20. DOI: https://doi.org/10.21037/tau.2016.11.18
9. Montorsi F, Briganti A, Salonia A, et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003;44:360-5. DOI: https://doi.org/10.1016/S0302-2838(03)00305-1
10. Miner M, Parish SJ, Billups KL, et al. Erectile dysfunction and subclinical cardiovascular disease. Sex Med Rev 2019; 7:455-63. DOI: https://doi.org/10.1016/j.sxmr.2018.01.001
11. Li L, Zhang Y, Ma M, et al. Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease. Front Cardiovasc Med 2024;11:1341819. DOI: https://doi.org/10.3389/fcvm.2024.1341819
12. Corona G, Cipriani S, Rastrelli G, et al. High triglycerides predicts arteriogenic erectile dysfunction and major adverse cardiovascular events in subjects with sexual dysfunction. J Sex Med 2016;13:1347-58. DOI: https://doi.org/10.1016/j.jsxm.2016.07.004
13. Zedan H, Hareadei AA, Abdel Sayed AA, et al. Cigarette smoking, hypertension and diabetes mellitus as risk factors for erectile dysfunction in upper Egypt. East Mediterr Health J 2010; 16:281-5. DOI: https://doi.org/10.26719/2010.16.3.281
14. Romeo JH, Seftel AD, Madhun ZT, Aron DC. Sexual function in men with diabetes type 2: association with glycemic control. J Urol 2000; 163:788-91. DOI: https://doi.org/10.1016/S0022-5347(05)67805-6
15. Bacon CG, Hu FB, Giovannucci E, et al. Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 2002;25:1458-63. DOI: https://doi.org/10.2337/diacare.25.8.1458
16. Moon KH, Park SY, Kim YW. Obesity and erectile dysfunction: from bench to clinical implication. World J Mens Health 2019; 37:138. DOI: https://doi.org/10.5534/wjmh.180026
17. Kovac JR, Labbate C, Ramasamy R, et al. Effects of cigarette smoking on erectile dysfunction. Andrologia 2015; 47:1087-92. DOI: https://doi.org/10.1111/and.12393
18. Nicolosi A, Glasser DB, Moreira ED, Villa M. Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study. Int J Impot Res 2003; 15:253-57. DOI: https://doi.org/10.1038/sj.ijir.3901010
19. Mirone V, Imbimbo C, Bortolotti A, et al. Cigarette smoking as risk factor for erectile dysfunction: results from an Italian epidemiological study. Eur Urol 2002;41:294-7. DOI: https://doi.org/10.1016/S0302-2838(02)00005-2
20. Lee WK, Yang DY, Yang SK ED 14. Is serum hsCRP associated with erectile dysfunction in aging men? Community based study. Transl Andro and Urol 2012;:Abs 2040.
21. Barassi A, Pezzilli R, Morselli-Labate AM, et al. Evaluation of microalbuminuria in patients with erectile dysfunction. J Sex Med. 2010; 7:1224-8. DOI: https://doi.org/10.1111/j.1743-6109.2009.01503.x
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