Original Papers - Andrology
Vol. 95 No. 1 (2023)
https://doi.org/10.4081/aiua.2023.11100

Semen and sex-steroid parameters among inflammatory bowel disease ulcerative colitis type according to rectal bleeding grade

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Received: 23 December 2022
Accepted: 31 December 2022
Published: 22 February 2023
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Inflammatory bowel disease, Sperm analysis, Testosterone, Reproductive healthcare, Hypogonadism

Authors

Darmadi Darmadi
https://orcid.org/0000-0001-5281-168X
Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Cennikon Pakpahan
cennikon.pakpahan@fk.unair.ac.id
https://orcid.org/0000-0003-0157-1131
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya; Department of Biomedical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Andri Rezano
https://orcid.org/0000-0003-2550-8794
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya; Department of Biomedical Sciences, Division of Cell Biology, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Wanly Syahrizal Pasaribu
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Herwindo Ahmad
Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Adriansyah Lubis
Department of Forensic and Medicolegal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Supardi Supardi
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Introduction: Hypogonadism and inflammato-ry bowel disease (IBD) are often associated. This association may influence sexual and reproductive function in IBD, including sperm profile and sex steroid hormones.

Patients and methods: This study included 59 IBD patients diagnosed with ulcerative colitis type IBD. Anamnesis was carried out regarding the history of the disease, along with a history of rectal bleeding. Evaluation proceeded with sperm and hormone examination if the patient agreed.

Results: Progressive motility sperm, immotile sperm, and normal sperm were found to be significantly different between the rectal bleeding groups. In grade 3 (more significant bleeding) progressive sperm (24.81 ± 5.85, p < 0.0001) and normal sperm (6.33 ± 12.56, p = 0.0003) rates tended to be lower, while immotile sperm tended to be higher (44.48 ± 11.21, p < 0.0001). Testosterone and free testosterone levels were also reported to be significantly different between groups, where grade 3 had lower levels 255.9 ± 30.08, p = 0.014 and 4.645 ± 0.5, p = 0.002 respectively.

Conclusions: Our study shows that the degree of rectal bleeding influences sperm motility and morphology, as well as testosterone and free testosterone levels. These results can concern managing IBD patients to fulfill reproductive health care.

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Semen and sex-steroid parameters among inflammatory bowel disease ulcerative colitis type according to rectal bleeding grade. (2023). Archivio Italiano Di Urologia E Andrologia, 95(1). https://doi.org/10.4081/aiua.2023.11100
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