Cerebral venous outflow abnormalities and inner ear: an underestimated piece of the puzzle?


Submitted: 12 July 2023
Accepted: 7 August 2023
Published: 22 August 2023
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Chronic Cerebrospinal Venous Insufficiency (CCSVI) is a medical disorder initially documented by Zamboni, which is distinguished by the impeded drainage of cerebrospinal fluid through the extracranial venous system. This obstruction mostly arises from the constriction or blockage of veins located in the cranial region and neck. This syndrome has the potential to result in the development of collateral circles, venous reflux, and iron accumulation within the central nervous system.


Zamboni P. The big idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J. R. Soc. Med. 2006;99:589–93. DOI: https://doi.org/10.1177/014107680609901122

Zamboni P, Galeotti R, Menegatti E, et al. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009;80:392-9. DOI: https://doi.org/10.1136/jnnp.2008.157164

Zamboni P, Morovic S, Menegatti E, et al. Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol. Int Angiol. 2011;30:571-97.

Menegatti E, Tessari M, Vannini ME, et al. High resolution M-mode evaluation of jugular vein valves in patients with neurological and neurosensory disorders. Curr Neurovasc Res. 2017;14:316-22. DOI: https://doi.org/10.2174/1567202614666171005122150

Ciorba A, Tessari M, Mazzoli M, et al. Cerebral inflow and outflow discrepancies in severe sudden sensorineural hearing loss. Curr Neurovasc Res. 2018;15:220-5. DOI: https://doi.org/10.2174/1567202615666180727091955

Ciorba A, Tessari M, Natale E, et al. Cerebral outflow discrepancies in recurrent benign paroxysmal positional vertigo: focus on ultrasonographic examination. Diagnostics (Basel) 2023;13:1902. DOI: https://doi.org/10.3390/diagnostics13111902

Alpini DC, Bavera PM, Di Berardino F, Barozzi, S., et al. Bridging the gap between chronic cerebrospinal venous insufficiency and Ménière disease. Veins and Lymphatics 2016;5:1-8. DOI: https://doi.org/10.4081/vl.2016.5687

Bavera PM, Di Berardino F, Cecconi P, et al. Chronic cerebro-spinal insufficiency in multiple sclerosis and meniere disease: same background, different patterns?. Veins and Lymphatics 2017;6:1-4. DOI: https://doi.org/10.4081/vl.2017.6533

Toro EF, Borgioli F, Zhang Q, et al. Inner-ear circulation in humans is disrupted by extracranial venous outflow strictures: Implications for Ménière’s disease. Veins and Lymphatics 2018;7:1-12. DOI: https://doi.org/10.4081/vl.2018.7156

Frau GN, Pagani R, Maronato F, et al. The role of omohyoid muscle entrapment of the internal jugular vein and is surgical transection in Ménière’s disease and other inner ear disorders. Veins and Lymphatics 2019;8:1. DOI: https://doi.org/10.4081/vl.2019.8431

Müller LO, Zhang Q, Contarino C, et al. Multi-compartment mathematical model for cerebrospinal fluid mechanics coupled to the systemic circulation: application to transverse sinus stenosis. Veins and Lymphatics 2019;8:1. DOI: https://doi.org/10.4081/vl.2019.8433

Bruno A, Califano L, Mastrangelo D, et al. Chronic cerebrospinal venous insufficiency in Ménière’s disease: diagnosis and treatment. Veins and Lymphatics 2014;3:1-4. DOI: https://doi.org/10.4081/vl.2014.3854

Foster CA, Breeze RE. The Meniere attack: an ischemia/reperfusion disorder of inner ear sensory tissues. Med Hypotheses. 2013;81(6):1108-15. DOI: https://doi.org/10.1016/j.mehy.2013.10.015

Alpini D, Bavera PM, Di Berardino F, Barozzi S, Cesarani A. Bilateral sudden sensorineural hearing loss and chronic venous cerebrospinal insufficiency: a case report. Phlebology. 2013;28:231-3. DOI: https://doi.org/10.1258/phleb.2012.012009

Tessari M, Ciorba A, Mueller LO, et al. Jugular valve function and petrosal sinuses pressure: a computational model applied to sudden sensorineural hearing loss. Veins and Lymphatics 2017;6:1-6. DOI: https://doi.org/10.4081/vl.2017.6707

Zamboni P, Menegatti E, Conforti P, et al. Assessment of cerebral venous return by a novel plethysmography method. J Vasc Surg. 2012;56:677-85. DOI: https://doi.org/10.1016/j.jvs.2012.01.074

Veroux P, Giaquinta A, Perricone D, et al. Internal jugular veins out flow in patients with multiple sclerosis: a catheter venography study. J Vasc Interv Radiol. 2013;24:1790-7. DOI: https://doi.org/10.1016/j.jvir.2013.08.024

Zamboni P, Galeotti R, Menegatti E, et al. A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. J. Vasc. Surg. 2009;50:1348–58. DOI: https://doi.org/10.1016/j.jvs.2009.07.096

Zamboni P, Galeotti R, Salvi F, et al. Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial. J Endovasc Ther. 2020;27:1526602819890110. DOI: https://doi.org/10.1177/1526602819890110

Migliorelli, A., & Ciorba, A. (2023). Cerebral venous outflow abnormalities and inner ear: an underestimated piece of the puzzle?. Veins and Lymphatics, 12(1). https://doi.org/10.4081/vl.2023.11585

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