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• 155 | Mitochondrial dynamics and therapeutic insights in spinal muscular atrophy: effects of MFN2 boosting in motoneurons and human fibroblasts

  Francesco Paolo Zummo¹, Serena Stanga¹, Letizia Paladino², Maria Beltran³, Francesco Fedeli⁴, Maria Rosa Soler³, Fabio Bucchieri⁵, Marina Boido¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy; ²E-Campus University, Palermo, Italy; ³Neuronal Signaling Unit, Experimental Medicine Department, University of Lleida-IRBLleida, Lleida, Spain; ⁴University of Pavia, Italy; ⁵Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  DOI https://doi.org/10.4081/jbr.2026.15407

  • 134 abstract views

• 142 | Drug repositioning reveals novel therapeutic candidates for spinal muscular atrophy

  Marina Boido¹, Daniela Maria Rasà¹, Serena Stanga¹, Ersilia Nicorvo¹, Pamela Santonicola², Nadia Mazzarella³, Antonella Camera², Roberto Iacomino², Ilenia Matino², Silvia Chasseur¹, Giuseppina Zampi², Piera Smeriglio⁴, Elia Di Schiavi², Alessandro Vercelli¹ | ¹Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy; ²Institute of Biosciences and BioResources ^IBBR, National Research Council CNR, Naples, Italy; ³Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" IGB-ABT, National Research Council CNR, Naples, Italy; ⁴Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  DOI https://doi.org/10.4081/jbr.2026.15394

  • 147 abstract views