Original Articles
Vol. 88 No. 2 (2015)
https://doi.org/10.4081/jbr.2015.5405

Gluten sensitivity and neurological manifestations

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Received: 29 June 2015
Published: 17 December 2015
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Gluten sensitivity, Non-celiac gluten sensitivity, HLA, EEG, Gluten-free diet

Authors

Agostino Berio
agostinoberio@ospedale-gaslini.ge.it
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Mother’s and Pediatric Sciences, University of Genoa, Genoa, Italy.
Giuseppe Mangiante
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Mother’s and Pediatric Sciences, University of Genoa, Genoa, Italy.
Gian Luigi Mariottini
Department of Earth, Environment and Life Sciences, University of Genoa, Genoa, Italy.
Attilia Piazzi
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Mother’s and Pediatric Sciences, University of Genoa, Genoa, Italy.
The authors report on six cases of gluten-sensitivity, also defined non-celiac gluten sensitivity, characterized by abdominal features (diarrhea, bloating, pain), genetic positivity for predisposition to celiac disease (DQB1* 02 in all cases; DQA1*05 in three; DQA1*02 in two, DQB1*03 in two), negative anti-t-Transglutaminase antibodies, normal mucosa on biopsy in four cases, type 1 of Marsh in one case. The subjects presented frequent central nervous system (CNS) symptoms: headache in three patients, somnolence in one, electroencephalogram aspecific alterations in three (in two of them with previous seizures), leptomeningeal cyst in one, intracranial calcification in one, cerebral gliosis in two. After a gluten-free diet, all intestinal and clinical CNS features remitted, but re-appeared after gluten reintroduction. On the basis of the neurological signs, the authors stress the relevance of immune innate system in the pathogenesis of these cases with possible subsequent evolution on immune adaptive system involvement.

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How to Cite



Gluten sensitivity and neurological manifestations. (2015). Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 88(2). https://doi.org/10.4081/jbr.2015.5405

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