Evaluation of antidiabetic activity of aqueous extract of Origanum floribundum Munby leaves in alloxan induced diabetic rats wistar

  • M'hamed Nasri | mhamed.nasri@g.ens-kouba.dz Laboratory of Ethnobotany and Naturel Substances, Department of Natural Science, École Normale Supérieure (ENS), Algiers, Algeria.
  • Mohamed Zaouani Laboratory of Food Hygiene and Quality Insurance System, Higher National Veterinary School, Algiers, Algeria.
  • Noura Mimoune Laboratory of biotechnology related to animal breeding, Institute of Veterinary Sciences, University Saad Dahleb, Blida, Algeria.
  • Fatma Amira Hani Laboratory of Food Hygiene and Quality Insurance System, Higher National Veterinary School, Algiers, Algeria.
  • Mohamed Mahdid Laboratory of Ethnobotany and Naturel Substances, Department of Natural Science, École Normale Supérieure (ENS), Algiers, Algeria.
  • Mohamed Toumi Department of Nature and Life Sciences, Faculty of Sciences, University Benyoucef Benkhedda, Algiers, Algeria.

Abstract

The present study aimed to evaluate the phytochemicals and the antidiabetic properties of Origanum floribundum aqueous extract. Phytochemical screening was conducted by using various standard procedures. Acute toxicity of the extract was determined by OECD guidelines 423. The antidiabetic activity of the plant was determined by alloxan-induced diabetes in Wistar albino rats. Data obtained showed the detection of various secondary metabolites such as alkaloids, flavonoids, saponins, terpenoids in the extract. No mortality was observed during acute toxicity studies up to the dose of 2000 mg/kg. The aqueous extract presented the ability of reducing blood glucose levels. These findings indicated that Origanum floribundum aqueous extract had various phytopharmacological activities and thus it would be useful to isolate and characterize the compounds responsible for these bioactivities in the future.

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Published
2021-01-14
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Original Articles
Keywords:
Aqueous extract, diabetes, rats, Origanum floribundum, acute toxicity
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How to Cite
Nasri, M., Zaouani, M., Mimoune, N., Hani, F. A., Mahdid, M., & Toumi, M. (2021). Evaluation of antidiabetic activity of aqueous extract of <em>Origanum floribundum</em&gt; Munby leaves in alloxan induced diabetic rats wistar. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 93(2). https://doi.org/10.4081/jbr.2020.9141