The effect of artificial sweeteners on body weight of mice

  • Iyad Ali | iyadali@najah.edu Department of Biochemistry, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus National University, Palestine, State of.
  • Naser Shraim Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine, State of.
  • Wafaa’ Atrash Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine, State of.
  • Aisha Sirafi Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine, State of.
  • Huda Abadi Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine, State of.

Abstract

Artificial Sweeteners (AS) are synthetic sugar substitutes that have sweetening potency hundreds of times more than the table sugar (sucrose). Artificial sweeteners are regarded as attractive alternatives to sugar as they add no calories to food intake. There are many hypotheses suggesting that AS may enhance appetite and cause weight gain. The aim of this study was to evaluate the effect of AS on food intake, fluid intake and body weight of mice. Acceptable daily intakes of AS solutions were administered orally to different set of mice for four weeks. The body weight, food consumption and fluid intake were measured. At the same time, the effect of Zingiber officinale extracts (natural appetite suppressor), Thymus vulgaris extracts (natural appetite inducer) and cyproheptadine (an appetite stimulant drug) on body weight of mice was evaluated. Artificial sweeteners consumption cause insignificant changes in body weight (p>0.05). However, the mean consumption of food and solutions varies significantly for some groups. The consumption of AS has no significant effect on body weight and may contribute to weight maintenance and energy balance as substitutes to high caloric sugar

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Published
2021-01-13
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Original Articles
Keywords:
Artificial Sweeteners, body weight, mice, Zingiber officinale, Thymus vulgaris, cyproheptadine
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How to Cite
Ali, I., Shraim, N., Atrash, W., Sirafi, A., & Abadi, H. (2021). The effect of artificial sweeteners on body weight of mice. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 93(2). https://doi.org/10.4081/jbr.2020.8783