https://doi.org/10.4081/ejtm.2021.9906
Influence of pain-related psychological factors on therapeutic outcomes in patients with chronic low back pain after oxygen-ozone treatment: a case-series
Submitted: 11 June 2021
Accepted: 25 June 2021
Published: 20 July 2021
Accepted: 25 June 2021
Abstract Views: 1249
PDF: 390
HTML: 5
HTML: 5
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The aim of the study was to identify the variables related to therapeutic success of intramuscular oxygen-ozone (O2O3) in patients with chronic low back pain (LBP). Twenty-one patients underwent an eight-session intramuscular-paravertebral O2O3 treatment with a weekly frequency. Numeric Rating Score for pain (NRSp), anxiety (NRSa), mood (NRSm), Oswestry Disability Index (ODI) and Physical and Mental Component Summary scores (PCS and MCS) of Short Form 12 (SF-12) were assessed baseline, after the treatment and at six-months follow-up. The ODI and NRSp scores showed significant improvement at the end of the treatment: the improvement in pain was maintained also at 6 months’ follow-up. A significant correlation between baseline NRSa and the variation of the NRSp and ODI was observed. There was a correlation between NRSm at baseline and the variation of the ODI. A moderate correlation between MCS-12 at baseline and the variation of the NRSp score was found. Surprisingly, patients with a more compromised psychological well-being due to LBP had better results after oxygen-ozone therapy. Therefore, NRSa, NRSm and MCS-12 scores could be useful predictors of good therapeutic outcome.
Maher C, Underwood M, Buchbinder R. Non-specific low back pain. Lancet. 2017 Feb 18;389(10070):736-747. Epub 2016 Oct 11.
DOI: https://doi.org/10.1016/S0140-6736(16)30970-9
Pincus T, Burton AK, Vogel S, Field AP. A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain. Spine (Phila Pa 1976). 2002 Mar 1;27(5):E109-20.
DOI: https://doi.org/10.1097/00007632-200203010-00017
Turk DC, Fillingim RB, Ohrbach R, Patel KV. Assessment of Psychosocial and Functional Impact of Chronic Pain. J Pain. 2016 Sep;17(9 Suppl):T21-49.
DOI: https://doi.org/10.1016/j.jpain.2016.02.006
de Sire A, Agostini F, Lippi L, Mangone M, Marchese S, Cisari C, Bernetti A, Invernizzi M. Oxygen-Ozone Therapy in the Rehabilitation Field: State of the Art on Mechanisms of Action, Safety and Effectiveness in Patients with Musculoskeletal Disorders. Biomolecules. 2021 Feb 26;11(3):356.
DOI: https://doi.org/10.3390/biom11030356
Apuzzo D, Giotti C, Pasqualetti P, Ferrazza P, Soldati P, Zucco GM. An observational retrospective/horizontal study to compare oxygen-ozone therapy and/or global postural re-education in complicated chronic low back pain. Funct Neurol. 2014 Jan-Mar;29(1):31-9.
DOI: https://doi.org/10.11138/FNeur/2014.29.1.031
Rahimi-Movaghar V, Eslami V. The major efficient mechanisms of ozone therapy are obtained in intradiscal procedures. Pain Physician. 2012 Nov-Dec;15(6):E1007-8.
DOI: https://doi.org/10.36076/ppj.2012/15/E1007
Iliakis E, Valadakis V, Vynios DH, Tsiganos CP, Agapitos E. Rationalization of the activity of medical ozone on intervertebral disc: A Histological and Biochemical Study. Rivista di Neuroradiologia. 2001;14(1_suppl):23-30.
DOI: https://doi.org/10.1177/19714009010140S105
Simonetti L, Raffi L, Cenni P, Agati R, Leonardi M. Pharmacological Mechanisms Underlying Oxygen-Ozone Therapy for Herniated Disc. Rivista di Neuroradiologia. 2003; 16(2_suppl_part2):201-204.
DOI: https://doi.org/10.1177/1971400903016SP250
Paoloni M, Di Sante L, Cacchio A, Apuzzo D, Marotta S, Razzano M, Franzini M, Santilli V. Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection. Spine (Phila Pa 1976). 2009 Jun 1;34(13):1337-44.
DOI: https://doi.org/10.1097/BRS.0b013e3181a3c18d
Biazzo A, Corriero AS, Confalonieri N. Intramuscular oxygen-ozone therapy in the treatment of low back pain. Acta Biomed. 2018 Mar 27;89(1):41-46.
Özcan Ç, Polat Ö, Çelik H, Uçar BY. The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain. Pain Pract. 2019 Nov;19(8):821-825.
DOI: https://doi.org/10.1111/papr.12812
Magalhaes FN, Dotta L, Sasse A, Teixera MJ, Fonoff ET. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. 2012 Mar-Apr;15(2):E115-29.
DOI: https://doi.org/10.36076/ppj.2012/15/E115
Celestin J, Edwards RR, Jamison RN. Pretreatment psychosocial variables as predictors of outcomes following lumbar surgery and spinal cord stimulation: a systematic review and literature synthesis. Pain Med. 2009 May-Jun;10(4):639-53.
DOI: https://doi.org/10.1111/j.1526-4637.2009.00632.x
Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996 Mar;34(3):220-33.
DOI: https://doi.org/10.1097/00005650-199603000-00003
Hinkle DE, Jurs SG, Wiersma W. Applied statistics for the behavioral sciences. Applied statistics for the behavioral sciences. 2nd ed. Boston: Houghton Mifflin Company. 1988.
Vowles KE, Gross RT, Sorrell JT. Predicting work status following interdisciplinary treatment for chronic pain. Eur J Pain. 2004 Aug;8(4):351-8.
DOI: https://doi.org/10.1016/j.ejpain.2003.10.009
Corrêa JB, Costa LO, de Oliveira NT, Sluka KA, Liebano RE. Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case-control study. Exp Brain Res. 2015 Aug;233(8):2391-9. Epub 2015 May 12.
DOI: https://doi.org/10.1007/s00221-015-4309-6
Mibu A, Nishigami T, Tanaka K, Manfuku M, Yono S. Difference in the impact of central sensitization on pain-related symptoms between patients with chronic low back pain and knee osteoarthritis. J Pain Res. 2019 May 29;12:1757-1765.
DOI: https://doi.org/10.2147/JPR.S200723
Brosschot JF. Cognitive-emotional sensitization and somatic health complaints. Scand J Psychol. 2002 Apr;43(2):113-21.
DOI: https://doi.org/10.1111/1467-9450.00276
Clark JR, Nijs J, Yeowell G, Holmes P, Goodwin PC. Trait Sensitivity, Anxiety, and Personality Are Predictive of Central Sensitization Symptoms in Patients with Chronic Low Back Pain. Pain Pract. 2019 Nov;19(8):800-810. Epub 2019 Jul 10.
DOI: https://doi.org/10.1111/papr.12809
Cagnie B, Coppieters I, Denecker S, Six J, Danneels L, Meeus M. Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI. Semin Arthritis Rheum. 2014 Aug;44(1):68-75. Epub 2014 Jan 8.
DOI: https://doi.org/10.1016/j.semarthrit.2014.01.001
Tirelli U, Cirrito C, Pavanello M, Piasentin C, Lleshi A, Taibi R. Ozone therapy in 65 patients with fibromyalgia: an effective therapy. Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1786-1788.
Charney DS. Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry. 1998;59 Suppl 14:11-4.
Wang JK. Antinociceptive effect of intrathecally administered serotonin. Anesthesiology. 1977; 47: 269-271.
DOI: https://doi.org/10.1097/00000542-197709000-00007
Kranzler JD, Gendreau JF, Rao SG. The psychopharmacology of fibromyalgia: a drug development perspective. Psychopharmacol Bull. 2002 Winter;36(1):165-213.
Farhanchi A, Karkhanei B, Amani N, Aghajanloo M, Khanlarzadeh E, Emami Z. Association of Serum Serotonin and Pain in Patients with Chronic Low Back Pain before and after Spinal Surgery. Pain Res Treat. 2018 Sep 20;2018:4901242.
DOI: https://doi.org/10.1155/2018/4901242
Moreno-Fernández A, Macías-García L, Valverde-Moreno R, Ortiz T, Fernández-Rodríguez A, Moliní-Estrada A, De-Miguel M. Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta Reumatol Port. 2019 Sep 29;44(3):244-249. English.
McGorry RW, Hsiang SM, Snook SH, Clancy EA, Young SL. Meteorological conditions and self-report of low back pain. Spine (Phila Pa 1976). 1998 Oct 1;23(19):2096-102; discussion 2103.
DOI: https://doi.org/10.1097/00007632-199810010-00011
How to Cite
Cantele, F., Tognolo, L., Caneva, F., Formaggio, E., Copetti, V., Venturin, A., Caregnato, A., & Masiero, S. (2021). Influence of pain-related psychological factors on therapeutic outcomes in patients with chronic low back pain after oxygen-ozone treatment: a case-series. European Journal of Translational Myology, 31(3). https://doi.org/10.4081/ejtm.2021.9906
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Sandra Zampieri, Ines Bersch, Piera Smeriglio, Elena Barbieri, Massimo Ganassi, Christiaan Leeuwenburg, Riccardo Rosati, Paolo Gargiulo, Amber Pond, H. Lee Sweeney, Ugo Carraro, Five Padua days on muscle and mobility medicine (2024Pdm3) 27 February - 2 March, 2024 at Hotel Petrarca, Thermae of Euganean Hills, Padua, and San Luca Hall, Prato della Valle, Padua, Italy , European Journal of Translational Myology: Vol. 33 No. 4 (2023)
- Sandra Zampieri, Ines Bersch, Piera Smeriglio, Elena Barbieri, Simona Boncompagni, Maria Chiara Maccarone, Ugo Carraro, Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February – 2 March, 2024 (2024Pdm3) , European Journal of Translational Myology: Vol. 34 No. 1 (2024)
You may also start an advanced similarity search for this article.