To contrast and reverse skeletal muscle weakness by Full-Body In-Bed Gym in chronic COVID-19 pandemic syndrome

  • Ugo Carraro Department of Biomedical Sciences, University of Padova, Italy; CIR-Myo - Interdepartmental Research Center of Myology, University of Padova, Italy; A-C M-C Foundation for Translational Myology, Padova, Italy.
  • Giovanna Albertin CIR-Myo - Interdepartmental Research Center of Myology, University of Padova, Italy; A-C M-C Foundation for Translational Myology, Padova, Italy.
  • Alessandro Martini Department of Neuroscience, University of Padova, Italy; Padova University Research Center "I Approve", University of Padov, Italy.
  • Walter Giuriati Department of Biomedical Sciences, University of Padova, Italy.
  • Diego Guidolin Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy.
  • Stefano Masiero CIR-Myo - Interdepartmental Research Center of Myology, University of Padova, Italy; Department of Neuroscience, Section of Rehabilitation, University of Padova, Italy.
  • Helmut Kern Ludwig Boltzmann Institute for Rehabilitation Research, St. Pölten, Austria; Physiko- und Rheumatherapie, St. Pölten, Austria.
  • Christian Hofer Physiko- und Rheumatherapie, St. Pölten, Austria.
  • Andrea Marcante UOC Recovery and Functional Rehabilitation, Lonigo Hospital, Azienda ULSS 8 Berica, Lonigo, Italy.
  • Barbara Ravara | barbara.ravara@unipd.it Department of Biomedical Sciences, University of Padova, Italy; CIR-Myo - Interdepartmental Research Center of Myology, University of Padova, Italy; A&C M-C Foundation for Translational Myology, Padova, Italy; Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy. http://orcid.org/0000-0002-0159-3245

Abstract

Mobility-impaired persons, either very old or younger but suffering with systemic neuromuscular disorders or chronic organ failures, spend small amounts of time for daily physical activity, contributing to aggravate their poor mobility by resting muscle atrophy. Sooner or later the limitations to their mobility enforce them to bed and to more frequent hospitalizations. We include among these patients at risk those who are negative for the SARS-COV-2 infection, but suffering with COVID-19 pandemic syndrome. Beside managements of psychological symptoms, it is mandatory to offer to the last group physical rehabilitation approaches easy to learn and self-managed at home. Inspired by the proven capability to recover skeletal muscle contractility and strength by home-based volitional exercises and functional electrical stimulation, we suggest also for chronic COVID-19 pandemic syndrome a 10–20 min long daily routine of easy and safe physical exercises that can activate, and recover from weakness, the main 400 skeletal muscles used for every-day mobility activities. Persons can do many of them in bed (Full-Body in-Bed Gym), and hospitalized patients can learn this light training before leaving the hospital. It is, indeed, an extension of well-established cardiovascular-respiratory rehabilitation training performed after heavy surgical interventions. Blood pressure readings, monitored before and after daily routine, demonstrate a transient decrease in peripheral resistance due to increased blood flow of many muscles. Continued regularly, Full-Body in-Bed Gym may help maintaining independence of frail people, including those suffering with the COVID-19 pandemic syndrome.

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References

Gava P, Kern H, Carraro U. Age-associated power decline from running, jumping, and throwing male masters world records. Exp Aging Res. 2015;41(2):115-35. DOI: https://doi.org/10.1080/0361073X.2015.1001648

Hopkins RO, Mitchell L, Thomsen GE, Schafer M, Link M, Brown SM. Implementing a mobility program to minimize post-intensive care syndrome. AACN Adv Crit Care. 2016 Apr-Jun;27(2):187-203. DOI: https://doi.org/10.4037/aacnacc2016244

Camillo CA, Osadnik CR, van Remoortel H, Burtin C, Janssens W, Troosters T. Effect of “add-on” interventions on exercise training in individuals with COPD: a systematic review. ERJ Open Res. 2016 Mar 29;2(1):00078-2015. DOI: https://doi.org/10.1183/23120541.00078-2015

Czyrny JJ, Kaplan RE, Wilding GE, Purdy CH, Hirsh J. Electrical foot stimulation: a potential new method of deep venous thrombosis prophylaxis. Vascular. Jan-Feb 2010;18(1):20-7. Erratum in Vascular 2010 Mar–Apr;18(2):121. DOI: https://doi.org/10.2310/6670.2010.00001

Saleem-Talib S, van Driel VJ, Chaldoupi SM, Nikolic T, van Wessel H, Borleffs CJW, Ramanna H. Leadless pacing: Going for the jugular. Pacing Clin Electrophysiol. 2019 Apr;42(4):395-399. DOI: https://doi.org/10.1111/pace.13607

Glenn WW, Hogan JF, Loke JS, Ciesielski TE, Phelps ML, Rowedder R. Ventilatory support by pacing of the conditioned diaphragm in quadriplegia. N Engl J Med. 1984 May 3;310(18):1150-5. DOI: https://doi.org/10.1056/NEJM198405033101804

Skalsky AJ, Lesser DJ, McDonald CM. Evaluation of phrenic nerve and diaphragm function with peripheral nerve stimulation and M-mode ultrasonography in potential pediatric phrenic nerve or diaphragm pacing candidates. Phys Med Rehabil Clin N Am. 2015 Feb;26(1):133-43. DOI: https://doi.org/10.1016/j.pmr.2014.09.010

Eskridge HR, Park LR, Brown KD. The impact of unilateral, simultaneous, or sequential cochlear implantation on pediatric language outcomes. Cochlear Implants Int. 2021 Jan 12:1-8. doi: 10.1080/14670100.2020.1871267. Online ahead of print. DOI: https://doi.org/10.1080/14670100.2020.1871267

Gallo S, Trevisi P, Rigon C, Caserta E, Seif Ali D, Bovo R, Martini A, Cassina M. Auditory Outcome after Cochlear Implantation in Children with DFNB7/11 Caused by Pathogenic Variants in TMC1 Gene. Audiol Neurootol. 2020 Dec 22:1-7. doi: 10.1159/000510156. Online ahead of print. DOI: https://doi.org/10.1159/000510156

Carraro U, Gava K, Baba A, Piccione F, Marcante A. Fighting muscle weakness in advanced aging by takehome strategies: Safe anti-aging full-body in- bed gym and functional electrical stimulation (FES) for mobility compromised elderly people. Biol Eng Med. 2016;1:1-4 DOI: https://doi.org/10.15761/BEM.1000106

Carraro U, Gava K, Musumeci A, Baba A, Piccione F, Marcante A. Safe Antiaging Full-Body In-Bed Gym and FES for Lazy Persons: Home In-Bed Exercises for Fighting Muscle Weakness in Advanced Age. In: Rehabilitation Medicine for Elderly Patients, Masiero S, Carraro U, Eds., pag. 43-52. ISBN 978-3-319-57405-9 ISBN 978-3-319-57406-6 (eBook)

Carraro U, Gava K, Baba A, Marcante A, Piccione F. To Contrast and Reverse Skeletal Muscle Atrophy by Full-Body In-Bed Gym, a Mandatory Lifestyle for Older Olds and Borderline Mobility-Impaired Persons. Adv Exp Med Biol. 2018;1088:549-560. DOI: https://doi.org/10.1007/978-981-13-1435-3_25

Ades PA, Keteyian SJ, Wright JS, Hamm LF, Lui K, Newlin K, Shepard DS, Thomas RJ. Increasing Cardiac Rehabilitation Participation From 20% to 70%: A Road Map From the Million Hearts Cardiac Rehabilitation Collaborative. Mayo Clinic proceedings. 2017;92(2):234-242. DOI: https://doi.org/10.1016/j.mayocp.2016.10.014

Vorona S, Sabatini U, Al-Maqbali S, Bertoni M, Dres M, Bissett B, Van Haren F, Martin AD, Urrea C, Brace D, Parotto M, Herridge MS, Adhikari NK, Fan E, Melo LT, Reid WD, Brochard LJ, Ferguson ND, Goligher EC. Inspiratory Muscle Rehabilitation in Critically Ill Adults: A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2018 Jun;15(6):735-744. DOI: https://doi.org/10.1513/AnnalsATS.201712-961OC

Soloveva NV, Makarova EV, Kichuk IV. Coronavirus syndrome: COVID-19 psychotrauma. Eur J Transl Myol. 2020; 30 (4): 9302.

Mohsen Khosravi. COVID-19 quarantine: Two-way interaction between physical activity and mental health. Eur J Transl Myol. 2020; 30 (4): 9509.

Angelini C, Siciliano G. Neuromuscular diseases and Covid-19: Advices from scientific societies and early observations in Italy. Eur J Transl Myol. 2020 Jun 22;30(2):9032. DOI: https://doi.org/10.4081/ejtm.2020.9032

Moro T, Paoli A. When COVID-19 affects muscle: effects of quarantine in older adults. Eur J Transl Myol. 2020 Jun 17;30(2):9069. DOI: https://doi.org/10.4081/ejtm.2020.9069

O’Hara Jennifer. Rehabilitation after COVID-19. Mayo Clinic News Network. 2020 October 3. Available at: https://newsnetwork.mayoclinic.org/ discussion/rehabilitation-after-covid-19/

Fiorenzato E, Zabberoni S, Costa A, Cona G. Cognitive and mental health changes and their vulnerability factors related to COVID-19 lockdown in Italy. PLoS One. 2021 Jan 27;16(1):e0246204. DOI: https://doi.org/10.1371/journal.pone.0246204

Demeco N, Marotta M, Barletta I, Pino C, Marinaro A, Petraroli L, Moggio L, Ammendolia A. Rehabilitation of patients post-COVID-19 infection: a literature review. J Int Med Res. 2020 Aug;48(8):300060520948382. DOI: https://doi.org/10.1177/0300060520948382

Wang TJ, Chau B, Lui M, Lam GT, Lin N, Humbert S. Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19. Am J Phys Med Rehabil. 2020 Sep;99(9):769-774. DOI: https://doi.org/10.1097/PHM.0000000000001505

Smith JM, Lee AC, Zeleznik H, Coffey Scott JP, Fatima A, Needham DM, Ohtake PJ. Home and Community-Based Physical Therapist Management of Adults With Post-Intensive Care Syndrome. Phys Ther. 2020 Jul 19;100(7):1062-1073. Available at: http://www.bio.unipd.it/bam/video/ InterviewCarraro-tutorial.mp4 DOI: https://doi.org/10.1093/ptj/pzaa059

Börjesson M, Onerup A, Lundqvist S, Dahlöf B. Physical activity and exercise lower blood pressure in individuals with hypertension: narrative review of 27 RCTs. Br J Sports Med. 2016 Mar;50(6):356-61. DOI: https://doi.org/10.1136/bjsports-2015-095786

Carneiro LS, Fonseca AM, Serrão P, Mota MP, Vasconcelos-Raposo J, Vieira-Coelho MA. Impact of physical exercise on catechol-O-methyltransferase activity in depressive patients: a preliminary communication Affect Disord. 2016 Mar 15;193:117-22. DOI: https://doi.org/10.1016/j.jad.2015.12.035

Simõe Seguro C, Silva Rebelo AC, Silva AG, Malaquias M, dos Santos A, Cardoso JS, Apolinário V, Veiga Jardim PC, Gentil P. Use of low volume, high effort resistance training to manage blood pressure in hypertensive patients inside a public hospital: a proof of concept study Eur. J Transl Myol. Eur J Transl Myol. 31 (1): 9547, 2021.

Masiero S, Maccarone MC, Agostini F. Health resort medicine can be a suitable setting to recover disabilities in patients tested negative for COVID-19 discharged from hospital? A challenge for the future. Int J Biometeorol. 2020 Oct;64(10):1807-1809. DOI: https://doi.org/10.1007/s00484-020-01947-4

Masiero S, Zampieri D, Del Felice A. The Place of Early Rehabilitation in Intensive Care Unit for COVID-19. Am J Phys Med Rehabil. 2020 Aug;99(8):677-678. DOI: https://doi.org/10.1097/PHM.0000000000001478

Khoshmanesh F, Thurgood P, Pirogova E, Nahavandi S, Baratchi S. Wearable sensors: At the frontier of personalised health monitoring, smart prosthetics and assistive technologies. Biosens Bioelectron. 2021 Mar 15;176:112946. DOI: https://doi.org/10.1016/j.bios.2020.112946

Gatsios D, Antonini A, Gentile G, Marcante A, Pellicano C, Macchiusi L, Assogna F, Spalletta G, Gage H, Touray M, Timotijevic L, Hodgkins C, Chondrogiorgi M, Rigas G, Fotiadis DI, Konitsiotis S. Feasibility and Utility of mHealth for the Remote Monitoring of Parkinson Disease: Ancillary Study of the PD_manager Randomized Controlled Trial. JMIR Mhealth Uhealth. 2020 Jun 29;8(6):e16414. DOI: https://doi.org/10.2196/16414

Graña Possamai C, Ravaud P, Ghosn L, Tran VT. Use of wearable biometric monitoring devices to measure outcomes in randomized clinical trials: a methodological systematic review BMC Med. 2020 Nov 6;18(1):310. DOI: https://doi.org/10.1186/s12916-020-01773-w

Kern H, Carraro U, Adami N, Biral D, Hofer C, Forstner C, Mödlin M, Vogelauer M, Pond A, Boncompagni S, Paolini C, Mayr W, Protasi F, Zampieri S. Home-based functional electrical stimulation rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion. Neurorehabil Neural Repair. 2010 Oct;24(8):709-21. DOI: https://doi.org/10.1177/1545968310366129

Carraro U, Kern H. Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation. Eur J Transl Myol. 2016 Jun 13;26(2):5894. DOI: https://doi.org/10.4081/ejtm.2016.5894

Carraro U, Kern H, Gava P, Hofer C, Loefler S, Gargiulo P, Mosole S, Zampieri S, Gobbo RB, Piccione P, Marcante A, Baba A, Schils S, Pond A, Gava F. Biology of muscle atrophy and of its recovery by FES in aging and mobility impairments: roots and by-products. Eur J Transl Myol. 2015 Aug 25;25(4):221-30. DOI: https://doi.org/10.4081/ejtm.2015.5272

Kern H, Barberi L, Löfler S, Sbardella S, Burggraf S, Fruhmann H, Carraro U, Mosole S, Sarabon N, Vogelauer M, Mayr W, Krenn M, Cvecka J, Romanello V, Pietrangelo L, Protasi F, Sandri M, Zampieri S, Musaro A. Electrical stimulation counteracts muscle decline in seniors. Front Aging Neurosci. 2014 Jul 24;6:189. DOI: https://doi.org/10.3389/fnagi.2014.00189

Carraro U, Kern H, Gava P, Hofer C, Loefler S, Gargiulo P, Edmunds K, Árnadóttir ÍD, Zampieri S, Ravara B, Gava F, Nori A, Gobbo V, Masiero S, Marcante A, Baba A, Piccione F, Schils S, Pond A, Mosole S. Recovery from muscle weakness by exercise and FES: lessons from Masters, active or sedentary seniors and SCI patients. Aging Clin Exp Res. 2017 Aug;29(4):579-590. DOI: https://doi.org/10.1007/s40520-016-0619-1

Zampieri S, Mosole S, Löfler S, Fruhmann H, Burggraf S, Cvečka J, Hamar D, Sedliak M, Tirptakova V, Šarabon N, Mayr W, Kern H. Physical exercise in aging: nine weeks of leg press or electrical stimulation training in 70 years old sedentary elderly people. Eur J Transl Myol. 2015 Aug 25;25(4):237-42. DOI: https://doi.org/10.4081/ejtm.2015.5374

Kern H, Carraro U. Home-Based Functional Electrical Stimulation of Human Permanent Denervated Muscles: A Narrative Review on Diagnostics, Managements, Results and Byproducts Revisited 2020. Diagnostics (Basel). 2020 Jul 29;10(8):529. DOI: https://doi.org/10.3390/diagnostics10080529

Recenti M, Ricciardi C, Edmunds K, Gislason MK, Gargiulo P. Machine learning predictive system based upon radiodensitometric distributions from mid-thigh CT images. Eur J Transl Myol. 2020 Apr 1;30(1):8892. DOI: https://doi.org/10.4081/ejtm.2019.8892

Albertin G, Ravara B, Kern H, Hofer C, Loefler S, Jurecka W, Guidolin D, Rambaldo A, Porzionato A, De Caro R, Zampieri S, Pond A, Alaibac M, Carraro U. Two-years of home based functional electrical stimulation recovers epidermis from atrophy and flattening after years of complete Conus-Cauda Syndrome. Medicine (Baltimore). 2019 Dec;98(52):e18509. DOI: https://doi.org/10.1097/MD.0000000000018509

Krenn M, Haller M, Bijak M, Unger E, Hofer C, Kern H, Mayr W Safe neuromuscular electrical stimulator designed for the elderly. Artif Organs. 2011 Mar;35(3):253-6. DOI: https://doi.org/10.1111/j.1525-1594.2011.01217.x

Zampieri S, Pietrangelo L, Loefler S, Fruhmann H, Vogelauer M, Burggraf S, Pond A, Grim-Stieger M, Cvecka J, Sedliak M, Tirpáková V, Mayr W, Sarabon N, Rossini K, Barberi L, De Rossi M, Romanello V, Boncompagni S, Musarò A, Sandri M, Protasi F, Carraro U, Kern H. Lifelong physical exercise delays age-associated skeletal muscle decline. J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):163-73. DOI: https://doi.org/10.1093/gerona/glu006

Glenn WW, Phelps ML. Diaphragm pacing by electrical stimulation of the phrenic nerve. Neurosurgery. 1985 Dec;17(6):974-84. DOI: https://doi.org/10.1227/00006123-198512000-00021

Berger D, Bloechlinger S, von Haehling S, Doehner W, Takala J, Z'Graggen WJ, Schefold JC. Dysfunction of respiratory muscles in critically ill patients on the intensive care unit. J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):403-12. DOI: https://doi.org/10.1002/jcsm.12108

Peñuelas O, Keough E, López-Rodríguez L, Carriedo D, Gonçalves G, Barreiro E, Lorente JÁ. Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill. Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):48. DOI: https://doi.org/10.1186/s40635-019-0259-9

Marrero HDJG, Stålberg EV, Cooray G, Corpeno Kalamgi R, Hedström Y, Bellander BM, Nennesmo I, Larsson L. Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods. Diagnostics (Basel). 2020 Nov 18;10(11):966. DOI: https://doi.org/10.3390/diagnostics10110966

Published
2021-03-02
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Original Articles
Keywords:
skeletal muscle weakness, home-based Full-Body in-Bed Gym, older olds, borderline mobility impaired persons, COVID-19 pandemic syndrome
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How to Cite
Carraro, U., Albertin, G., Martini, A., Giuriati, W., Guidolin, D., Masiero, S., Kern, H., Hofer, C., Marcante, A., & Ravara, B. (2021). To contrast and reverse skeletal muscle weakness by Full-Body In-Bed Gym in chronic COVID-19 pandemic syndrome. European Journal of Translational Myology, 31(1). https://doi.org/10.4081/ejtm.2021.9641