Exercise preserves muscle mass and force in a prostate cancer mouse model

  • Darpan I. Patel | pateld7@uthscsa.edu School of Nursing, The University of Texas Health at San Antonio, San Antonio, TX, USA; Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, The University of Texas Health at San Antonio, San Antonio, TX, USA; Barshop Institute for Longevity and Aging Studies, The University of Texas Health at San Antonio, San Antonio, TX, United States.
  • Kira Abuchowski School of Nursing, The University of Texas Health at San Antonio, San Antonio, TX, United States.
  • Bilal Sheikh School of Nursing, The University of Texas Health at San Antonio, San Antonio, TX, United States.
  • Paul Rivas Department of Urology, School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, United States.
  • Nicolas Musi Barshop Institute for Longevity and Aging Studies, The University of Texas Health at San Antonio, San Antonio, TX, USA; School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, USA; The Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, United States.
  • A. Pratap Kumar Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, The University of Texas Health at San Antonio, San Antonio, TX, USA; Department of Urology, School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, United States.

Abstract

The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p<0.01).

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Published
2019-11-12
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Original Articles
Keywords:
cachexia, sarcopenia, muscle strength, physical activity
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How to Cite
Patel, D., Abuchowski, K., Sheikh, B., Rivas, P., Musi, N., & Kumar, A. P. (2019). Exercise preserves muscle mass and force in a prostate cancer mouse model. European Journal of Translational Myology, 29(4). https://doi.org/10.4081/ejtm.2019.8520