The correlation between creatinine levels and estimated glomerular filtration rate (GFR) with blood glucose levels in diabetes mellitus type 2 patients

Ani Riyani; Rizka Nerisandi; Wiwin Wiryanti; Widda Rahmah; Nani Kurnaeni

doi:10.4081/hls.2023.11790

Authors

Ani Riyani
ani_riyanianalis@yahoo.com
Faculty of Medical Laboratory Technologist, Ministry of Health Bandung Health Polytechnic, Bandung, Indonesia.
Rizka Nerisandi Faculty of Medical Laboratory Technologist, Ministry of Health Bandung Health Polytechnic, Bandung, Indonesia. https://orcid.org/0009-0009-6453-5446
Wiwin Wiryanti Faculty of Medical Laboratory Technologist, Ministry of Health Bandung Health Polytechnic, Bandung, Indonesia.
Widda Rahmah Department of Chemical Engineering, Faculty of Industrial Engineering, Bandung Institute of Technology, Bandung, Indonesia.
Nani Kurnaeni Faculty of Medical Laboratory Technologist, Ministry of Health Bandung Health Polytechnic, Bandung, Indonesia.

Diabetes mellitus (DM) was a group of metabolic diseases characterized by hyperglycemia. Measuring the blood creatinine level and calculating the estimated glomerular filtration rate (GFR) was crucial in determining if a person had impaired kidney function. These tests provided valuable insights into the progression of type 2 diabetes mellitus and its associated risk of kidney failure. The objective of this study was to investigate the correlation between average creatinine levels and GFR with blood glucose levels in type 2 DM patients. This correlative research used a cross-sectional approach and included samples from 30 patients with type 2 DM at a hospital in Bandung, Indonesia. The patients' blood glucose and blood creatinine levels were measured using GFR calculations and a Kenza Max photometer, respectively. The sampling method used was accidental sampling, with the sample criteria being type 2 DM patients who were willing to be respondents and did not have hypertension. The average creatinine levels and estimated GFR values were 0.97 mg/dL and 84.971 mL/min/1.73m². The results of the Pearson correlation test indicated non-significant correlations (p > 0.05, p = 0.703 and 0.819). This suggested that there was no significant relationship between creatinine levels and estimated GFR and blood glucose levels in type 2 DM patients. This study provided a foundational exploration of the link between blood glucose levels and kidney function, which could contribute to developing methods for examining kidney diseases in type 2 DM patients. This study's findings underscore the complexity of the relationship between metabolic control and renal function in type 2 diabetes mellitus patients, highlighting the need for individualized patient assessment and management strategies.

Mboi N, Syailendrawati R, Ostroff SM, et al. The state of health in Indonesia’s provinces, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Glob Heal 2022;10:e1632–45.

Bestari IL. Characteristics of patients with type 2 diabetes mellitus at Surabaya Haji General Hospital. Indon J Public Health 2020;15:286–94. DOI: https://doi.org/10.20473/ijph.v15i3.2020.286-294

Akoit EE, Efendi F, Dewi YS, et al. Impact of diabetes self-management education in middle-aged patients with type 2 diabetes mellitus: A systematic review. Gac Med Caracas 2022;130:S1183–95. DOI: https://doi.org/10.47307/GMC.2022.130.s5.44

Hadisuyatmana S, Malik G, Efendi F, Reisenhofer S, Boyd J. The experiences and barriers in addressing type 2 diabetes mellitus-associated erectile dysfunction: a mixed method systematic review. Syst Rev 2023;12:138. DOI: https://doi.org/10.1186/s13643-023-02303-4

American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes - 2021. Diabetes Care 2021;44:S15–33. DOI: https://doi.org/10.2337/dc21-S002

Susilo H, Alsagaff MY, Pikir BS, et al. Type II Diabetes as the Main Risk Factor of Arterial Stiffness in Chronic Kidney Disease Patients. ACM Int Conf Proceeding Ser. 2022;210–4. DOI: https://doi.org/10.1145/3545729.3545771

International Diabetes Federation. IDF Diabetes Atlas 2021. 10th ed. International Diabetes Federation. 2021. 30–39 p.

Fadli, Nursalam, Uly N, Iskandar R, Amir H, Ahmad AS. Factors Associated with Self-Management Behaviour among Type 2 Diabetes Mellitus Patients. Gaceta Medica de Caracas 2023;131:287–92. DOI: https://doi.org/10.47307/GMC.2023.131.2.4

Saputro SA, Pattanateepapon A, Pattanaprateep O, Aekplakorn W, McKay GJ, Attia J, et al. External validation of prognostic models for chronic kidney disease among type 2 diabetes. J Nephrol 2022;35:1637–53. DOI: https://doi.org/10.1007/s40620-021-01220-w

Muhammad Haskani NH, Goh HP, Wee DVT, et al. Medication Knowledge and Adherence in Type 2 Diabetes Mellitus Patients in Brunei Darussalam: A Pioneer Study in Brunei Darussalam. Int J Environ Res Public Health 2022;19:7470. DOI: https://doi.org/10.3390/ijerph19127470

Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of Diabetes 2017. J Diabetes Res 2018;2018:3086167. DOI: https://doi.org/10.1155/2018/3086167

Lim AKH. Diabetic nephropathy – Complications and treatment. Int J Nephrol Renovasc Dis 2014;7:361–81. DOI: https://doi.org/10.2147/IJNRD.S40172

Putra IG, Soebroto H, Sembiring YE, Tjempakasari A. Patency durability of non-tunneled hemodialysis’ catheter in adult patients with chronic kidney disease stadium 5 with diabetes mellitus and non-diabetes mellitus. Ital J Vasc Endovasc Surg 2023;30:15–9. DOI: https://doi.org/10.23736/S1824-4777.22.01568-6

Vallon V, Komers R. Pathophysiology of the Diabetic Kidney. Compr Physiol 2011;1:1175–232. DOI: https://doi.org/10.1002/cphy.c100049

Shahbaz H, Gupta M. Creatinine Clearance. StatPearls. 2023.

Tarwater K. Estimated Glomerular Filtration Rate Explained. Mo Med 2011;108:29–32.

Botev R, Mallié J-P, Couchoud C, et al. Estimating Glomerular Filtration Rate: Cockcroft–Gault and Modification of Diet in Renal Disease Formulas Compared to Renal Inulin Clearance. Clin J Am Soc Nephrol 2009;4:899–906. DOI: https://doi.org/10.2215/CJN.05371008

Dedi EH. Gambaran Kadar Ureum Dan Kreatinin Pada Penderita Diabetes Melitus Tipe 2. Poltekkes Tanjungkarang; 2020.

Kurniawan MR, Kusrini E. Ureum and Creatinine Health Study in Patients Diabetes Mellitus. Indones J Med Lab Sci Technol 2020;2:85–92. DOI: https://doi.org/10.33086/ijmlst.v2i2.1565

Levey AS, Titan SM, Powe NR, et al. Kidney Disease, Race, and GFR Estimation. Clin J Am Soc Nephrol 2020;15:1203–12. DOI: https://doi.org/10.2215/CJN.12791019

Aini, Mentari IN. Profil Lama Diagnosa Diabetes Melitus Terhadap Nilai Estimasi Laju Filtrasi Glomelurus (LFG). J Penelit dan Kaji Ilm Kesehat Politek Medica Farma Husada Mataram. 2019;5:86–90.

Dabla PK. Renal function in diabetic nephropathy. World J Diabetes 2010;1:48–56. DOI: https://doi.org/10.4239/wjd.v1.i2.48

Musa A, Azizahwati. Hubungan antara UACR dengan eGFR sebagai penand gangguan fungsi ginjal pada pasien diabetes melitus tipe 2 RSUPN Dr. Cipto Mangunkusumo. Universitas Indonesia; 2012.

Fontela PC, Winkelmann ER. Estimated glomerular filtration rate in patients with type 2 diabetes mellitus. Rev Assoc Med Bras 2014;60:531–7. DOI: https://doi.org/10.1590/1806-9282.60.06.010

Riyani, A., Nerisandi, R., Wiryanti, W., Rahmah, W., & Kurnaeni, N. (2023). The correlation between creatinine levels and estimated glomerular filtration rate (GFR) with blood glucose levels in diabetes mellitus type 2 patients. Healthcare in Low-Resource Settings, 12(1). https://doi.org/10.4081/hls.2023.11790