Ethanolic extract of red dragon fruit inhibits growth of mosquito larvae
https://doi.org/10.4081/hls.2023.11772
Accepted: 17 November 2023
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Controlling the vector by eradicating mosquito larvae is frequently done by spreading Abate powder containing 1% Temephos as a larvicide agent. However, the use of Abate powder will possibly increase pesticide residue contamination in the water. This study aimed to explore the potential use of ethanolic extract from red dragon fruit skin to kill mosquito larvae. An experimental laboratory study was performed to examine the larvicidal activity of ethanolic extract from red dragon fruit skin. Maceration method was used to extract active compounds from the fruit skin. Subsequently, the viscous extract was formulated using the wet granulation method to obtain powder form. The larvicide test was done by comparing the lethal concentration (LC50) of mosquito larvae after treatment using the extract and the reference larvicide agent, 1% Temephos Abate. The treatment groups consisted of four different extract concentrations of 1%, 2%, 3%, and 4%. The LC50 of each treatment groups was then calculated against the negative control group. Phytochemical screening showed that the ethanol extract of red dragon fruit skin contains alkaloids, flavonoids, saponins, triterpenoids, and tannins. The larvicide test on Aedes aegypti mosquito larvae showed that the extract treatment hardly killed the Aedes aegypti mosquito larvae. However, on Culex mosquito larvae, the ethanolic extract of red dragon fruit skin was able to kill mosquito larvae, with LC50 value of of 19.06%. The ethanolic extract of red dragon fruit skin was effective on killing the Culex mosquito larvae but not the Aedes aegypti mosquito larvae.
Santoso S, Yahya Y, Suryaningtyas NH, et al. Studi Bioekologi Nyamuk Mansonia Spp Vektor Filariasis Di Kabupaten Tanjung Jabung Timur, Provinsi Jambi. Vektora J Vektor dan Reserv Penyakit 2016;8:71–80. DOI: https://doi.org/10.22435/vk.v8i2.4216.71-80
Mulyatno KC, Kotaki T, Yotopranoto S, et al. Detection and serotyping of dengue viruses in aedes aegypti and aedes albopictus (Diptera: Culicidae) collected in Surabaya, Indonesia from 2008 to 2015. Jpn J Infect Dis 2018;71:58–61. DOI: https://doi.org/10.7883/yoken.JJID.2017.117
Ananta LK, Efendi F, Makhfudli, et al. Social Support and its Correlation with “3M Plus” Behavior in the Prevention of Dengue Hemorrhagic Fever. Indian J Public Heal Res Dev 2019;10:2681. DOI: https://doi.org/10.5958/0976-5506.2019.02274.5
Nadifah F, Farida Muhajir N, Arisandi D, D. Owa Lobo M. Identifikasi Larva Nyamuk Pada Tempat Penampungan Air Di Padukuhan Dero Condong Catur Kabupaten Sleman. J Kesehat Masy Andalas 2017;10:172. DOI: https://doi.org/10.24893/jkma.10.2.172-178.2016
Adnyana IMDM, Sumarya IM, Sudaryati NLG. Efficacy and Toxicity of Parasayu incense ash as a Larvicide for the Eradication of Aedes aegypti (Diptera: Culicidae) Mosquito Larvae. J Res Pharm 2022;26:1805–13. DOI: https://doi.org/10.29228/jrp.271
Wahidah FF, Hamidah, Rosmanida. Essential oil characterization of plant as breeding site of aedes aegypti and aedes albopictus. Ann Biol 2020;36:245–7.
Buchori D, Mawan A, Nurhayati I, et al. Risk Assessment on the Release of Wolbachia-Infected Aedes aegypti in Yogyakarta, Indonesia. Insects 2022;13(10). DOI: https://doi.org/10.3390/insects13100924
Indonesia KKR. Membuka Lembaran Baru. Laporan Tahunan 2022 Deman Berdarah Dengue. Germas 2022. 1–36 p.
Rampengan NH. Japanese Ensefalitis. J Biomedik 2018;8:10–22.
Kementerian Kesehatan RI. Direktorat Pencegahan dan Pengendalian Penyakit Menular Kementerian Kesehatan. Kementerian Kesehatan Republik Indonesia. 2018;3:1–119.
Hanafiah E, Syuhriatin S, Meidatuzzahra D, Swandayani RE. Efektivitas Penggunaan Abate dan Bactivec Terhadap Kematian Larva Nyamuk Aedes sp. di Kabupaten Lombok Barat. Lomb J Sci 2019;1:38–41.
Utami RW, Haqi DN. Hubungan Faktor Predisposisi Dengan Keberadaan Jentik Nyamuk Aedes Aegypti. J Promkes 2018;6:227. DOI: https://doi.org/10.20473/jpk.V6.I2.2018.227-241
Lusno MFD, Yudhastuti R, Haksama S, Dwirahmadi F, Prayoga D, Farid AF, et al. Integration of climate, transmission, and spread of dengue hemorrhagic fever in endemic areas. J Public Health Africa 2023;14(S2).
Sari DN, Wahdaningsih S, Kurniawan H. Analisis Gugus Fungsi Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus). J Mhs Farm Fak Kedokt UNTAN 2021;5:1–5.
Diyatri I, Juliastuti WS, Ridwan RD, Ananda GC, Waskita FA, Juliana N V, et al. Antibacterial effect of a gingival patch containing nano-emulsion of red dragon fruit peel extract on Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum assessed in vitro. J Oral Biol Craniofacial Res 2023;13:386–91. DOI: https://doi.org/10.1016/j.jobcr.2023.03.011
Lim TW, Lim CJ, Liow CA, et al. Studies on the storage stability of betacyanins from fermented red dragon fruit (Hylocereus polyrhizus) drink imparted by xanthan gum and carboxymethyl cellulose. Food Chem 2022;393. DOI: https://doi.org/10.1016/j.foodchem.2022.133404
Sigit M, Rahmawati I, Candram AYR, Prasetyo FB. Pengaruh Pemberian Ekstrak Dayn Lidah Buaya (Aloe vera) Terhadap Mortalitas Larva Nyamuk. J Vitek Bid Kedokt Hewan 2022;12:17–21. DOI: https://doi.org/10.30742/jv.v12i1.96
Sok Yen F, Shu Qin C, Tan Shi Xuan S, et al. Hypoglycemic Effects of Plant Flavonoids: A Review. Evidence-based Complement Altern Med 2021;2021. DOI: https://doi.org/10.1155/2021/2057333
Ahmad A, Adriyanto A. Efektivitas Serbuk Biji Pepaya (Carica Papaya L.) Terhadap Kematian Jentik (Larva) Culex sp. J Med (Media Inf Kesehatan) 2019;6:104–12. DOI: https://doi.org/10.36743/medikes.v6i1.186
La EOJ, Sawiji RT, Yuliawati AN. Skrining Fitokimia Dan Analisis Kromatografi Lapis Tipis Ekstrak Etanol Kulit Buah Naga Merah. Indones J Pharmacy Nat Prod 2020;03:45–58.
Noor MI, EY dan Z. Identifikasi Kandungan Ekstrak Kulit Buah Naga Merah Menggunakan Fourier Transform Infrared ( FTIR ) dan Fitokimia Identification Content of the Red Dragon Fruit Extract Skin Using Fourier Transform Infrared ( FTIR ) and Phytochemistry. J Aceh Phys Soc 2016;5:14–6.
Pujiastuti E, El’Zeba D. Perbandingan Kadar Flavonoid Total Ekstrak Etanol 70 % Dan 96 % Kulit Buah Naga Merah ( Hylocereus). Cendekia J Pharm 2021;5:28–43. DOI: https://doi.org/10.31596/cjp.v5i1.131
Suhaimi, Kartikasari D. Uji aktivitas larvasida granul ekstrak batang seledri (Avium graveolens) pada larva instar 3 Aedes aegypti. J Insa Farm Indones 2018;1:260–7.
Utami WW, Ahmad AR, Malik A. Uji Aktivitas Larvasida Ekstrak Daun Jarak Kepyar (Ricinus communis L.) Terhadap Larva Nyamuk Aedes aegypti. J Fitofarmaka Indones 2016;3:141–5. DOI: https://doi.org/10.33096/jffi.v3i1.174
Kewa M, Almet J, Laut MM. Median Lethal Concentration (Lc50) Ekstrak Daun Sirsak (Annona muricata Linn) Terhadap Larva Culex sp di Kota Lampung. J Kaji Vet 2020;4:791–2. DOI: https://doi.org/10.35508/jkv.v8i2.3078
Abdurrozak MI, Syafnir L, Sadiyah ER. Uji Efektivitas Ekstrak Etanol Daun Angsana (Pterocarpus Indicus Willd) sebagai Biolarvasida terhadap Larva Nyamuk Culex Sp. J Ris Farm 2021;1:33–7. DOI: https://doi.org/10.29313/jrf.v1i1.45
Ramayanti I, Febriani R. Uji Efektivitas Larvasida Ekstrak Daun Pepaya (Carica papaya Linn) terhadap Larva Aedes aegypti. Syifa’ Med J Kedokt dan Kesehat 2016;6:79. DOI: https://doi.org/10.32502/sm.v6i2.1383
Wulansari. Analisis Senyawa Metabolit Sekunder dan Uji Aktivitas Larvasida Alami Pada Ekstral Etanol Daun Bidara (Ziziphus mauritiana Lamk.) Terhadap Larva Aedes aegypti. Skripsi. Islam Negeri Maulana Malik Ibrahim, Malang; 2022 Vol. 3.
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