https://doi.org/10.4081/ecj.2026.14987
L-lactate in acute mesenteric ischemia: toward integrated diagnostic and therapeutic stratification
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Published: 22 April 2026
Dear Editor,
We read with great interest the article entitled “L-lactate in acute mesenteric ischemia: a reliable biomarker for diagnosis and prognosis?”.1 The authors provide valuable insight into the prognostic role of preoperative L-lactate levels in patients with Acute Mesenteric Ischemia (AMI), a condition associated with substantial diagnostic challenges and high mortality. Identifying reliable biomarkers for early risk stratification is of undeniable clinical importance. Nevertheless, we believe that several additional aspects could further enhance the clinical impact and scientific depth of this important study. [...]
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1. Deryol R, Şeker D, Şeker GE, Balas Ş. L-lactate in acute mesenteric ischemia: a reliable biomarker for diagnosis and prognosis? Emerg Care J 2025;21:14023. DOI: https://doi.org/10.4081/ecj.2025.14023
2. Garzelli L, Nuzzo A, Copin P, et al. Contrast-Enhanced CT for the Diagnosis of Acute Mesenteric Ischemia. AJR Am J Roentgenol 2020;215:29-38. DOI: https://doi.org/10.2214/AJR.19.22625
3. Shi Y, Zhao B, Zhou Y, et al. Endovascular revascularization vs open surgical revascularization as the first strategy for arterial acute mesenteric ischemia: A systematic review and meta-analysis. J Vasc Surg 2024;80:1883-93.e2. DOI: https://doi.org/10.1016/j.jvs.2024.07.084
4. Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004;32:1637-42. DOI: https://doi.org/10.1097/01.CCM.0000132904.35713.A7
5. Zenger S, Demir Piroğlu I, Çevik A, et al. The importance of serum intestinal fatty acid-binding protein for the early diagnosis of acute mesenteric ischemia. [Akut mezenter iskeminin erken tanısında serum intestinal yağ asidi bağlayıcı proteininin önemi.] Ulus Travma Acil Cerrahi Derg 2021;27:278-83. DOI: https://doi.org/10.14744/tjtes.2020.35823
6. Monita MM, Gonzalez L. Acute Mesenteric Ischemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; June 26, 2023.
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