https://doi.org/10.4081/ecj.2026.14967
Epidemiology and temporal trends of carbon monoxide poisoning mortality in the United States, 2018–2024
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Published: 7 July 2026
Dear Editor,
Carbon monoxide (CO) poisoning remains a significant cause of preventable morbidity and mortality worldwide.1 As a colorless, odorless, and non-irritating gas typically generated by the incomplete combustion of carbon-containing fuels, CO is especially dangerous because exposure may occur without warning. Common sources include residential heating systems, gas-powered appliances, motor vehicles, and generators, making both accidental and intentional exposures a persistent public health issue.2 The clinical manifestations of poisoning range from mild, nonspecific symptoms, up to severe neurological impairment and death, mostly depending on concentration and duration of exposure.2 [...]
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1. Mattiuzzi C, Lippi G. Worldwide epidemiology of carbon monoxide poisoning. Hum Exp Toxicol 2020;39:387-92.
2. Bleecker ML. Carbon monoxide intoxication. Handb Clin Neurol 2015;131:191-203.
3. Centers for Disease Control and Prevention. Wide-Ranging Online Data for Epidemiologic Research (WONDER). Last accessed, February 11, 2026. Available from: https://wonder.cdc.gov/mcd-icd10-provisional.html
4. Rupert DJ, Poehlman JA, Damon SA, Williams PN. Risk and protective behaviours for residential carbon monoxide poisoning. Inj Prev 2013;19:119-23.
5. Mukhopadhyay S, Hirsch A, Etienne S, et al. Surveillance of carbon monoxide-related incidents - Implications for prevention of related illnesses and injuries, 2005-2014. Am J Emerg Med 2018;36:1837-44.
CRediT authorship contribution
The authors contributed equally to the present work.
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Data Availability Statement
Data are publicily available on Centers for Disease Control and Prevention (CDC) WONDER (Wide-Ranging Online Data for Epidemiologic Research) Provisional Multiple Cause of Death database
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