https://doi.org/10.4081/ecj.2025.13421
SOS: a silent threat. A case report on paracetamol overdose
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Published: 9 April 2025
Paracetamol, also known as acetaminophen, is a widely used non-opioid analgesic and antipyretic agent. As an easily accessible Over-The-Counter (OTC) medication, the risk of exceeding the maximum daily dosage and resulting in an overdose is significant. Here, we present a case of paracetamol overdose of a 24-year-old male who consumed 15 tablets (9.75 g) of paracetamol given as OTC to relieve his chest pain. The patient was treated with Nacetylcysteine (NAC) and managed symptomatically. This case involves a paracetamol overdose resulting from the patient’s inadequate comprehension of the term Si Opus Sit (SOS), which translates to “as needed”. This case highlights the importance of patient counseling in the rational use of drugs.
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Benlamkaddem S, Iken I, Houari N, et al. Paracetamol self-poisoning: when oral N-acetylcysteine saves life? A case report. Pan Afr Med J 2018;29:83.
Shiffman S, Battista DR, Kelly JP, et al. Prevalence of exceeding maximum daily dose of paracetamol and seasonal variations in cold-flu season. Br J Clin Pharmacol 2018;84:1250-7.
Caparrotta TM, Antoine DJ, Dear JW. Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature. Eur J Clin Pharmacol 2018;74:147-60.
Pharmaceutical Society of Australia. Dispensing practice guidelines. Available from: https://www.psa.org.au/wp-content/uploads/2019/06/5574-PSA-Dispensing-Practice-guidelines_FINAL.pdf
Chiew AL, Domingo G, Buckley NA, et al. Hepatotoxicity in a child following an accidental overdose of liquid paracetamol. Clin Toxicol (Phila) 2020;58:1063-6.
Penna A, Buchanan N. Paracetamol poisoning in children and hepatotoxicity. Br J Clin Pharmacol 1991;32:143-9.
Terrie YC, BSPharm, RPh. Proper selection of OTC products: the role of the pharmacist. Pharm Times 2007. Available from: https://www.pharmacytimes.com/view/otc_2007-06_4794
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