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• 32 | Trifolium pratense extract mitigates skeletal muscle atrophy: a nutraceutical approach for the prevention of sarcopenia Tommaso Raiteri¹, H. Meskine², M. Paiella¹, A. Trabalzini¹, I. Varfaj⁴, L. Salvadori², F. Riuzzi¹, R. Sardella⁴, F. Orlandi³, N. Filigheddu², G. Sorci¹ | ¹Department of Medicine and Surgery, University of Perugia, Italy; ²Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; ³Department of Civil and Environmental Engineering, University of Perugia, Italy; ⁴Department of Pharmaceutical Sciences, University of Perugia, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15480

  93

• 30 | The advanced glycation end-products (ages)/rage axis drives sarcobesity, which is restrained by Vaccinium macrocarpon extract Martina Paiella^1|2, L. Salvadori^2|3, T. Raiteri^1|2, G. Gentili^1|2, S. Chiappalupi^1|2, T. Manenti⁴, G. Sorci^1|2, F. Prodam⁵, N. Filigheddu^2|3, F. Riuzzi^1|2 | ¹Dept. Medicine and Surgery, Univ. Perugia, Perugia, Italy; ²Interuniversity Institute of Myology (IIM), Perugia, Italy; ³Dept. Translational Medicine, Univ. Piemonte Orientale, Novara, Italy; ⁴Laboratori Biokyma srl, Anghiari, Italy; ⁵Dept. Health Science, Univ. Piemonte Orientale, Novara, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15478

  97

• 22 | Subcutaneous injection of microencapsulated Sertoli cells is more efficacious than deflazacort treatment in mdx mice Sara Chiappalupi^1|2, G. Gentili^1|2, L. Salvadori^2|3, I. Arato¹, F. Mancuso¹, M. Paiella^1|2, F. Riuzzi^1|2, R. Calafiore¹, G. Luca¹, G. Sorci^1|2 | ¹Department of Medicine and Surgery, University of Perugia, Italy; ²Interuniversity Institute of Myology (IIM), Perugia, Italy; ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. | S. Chiappalupi and G. Sorci shared Senior authorship; S. Chiappalupi and G. Gentili contributed equally.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15470

  90

• 43 | Synergistic negative effects of advanced glycation end products and tumor-conditioned medium on C2C12 myotubes and the protective activity of Vaccinium macrocarpon T. Raiteri², Hajar Meskine¹, L. Salvadori¹, M. Paiella², F. Prodam³, F. Riuzzi², N. Filigheddu¹ | ¹Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; ²Department of Medicine and Surgery, University of Perugia, Perugia, Italy; ³Department of Health Science, University of Piemonte Orientale, Novara, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15491

  87

• 42 | RAGE-ablated skeletal muscles resist cancer-induced atrophy through Akt-GSK-3β-PGC-1α pathway and fast-to-slow myofiber transition Giulia Gentili^1|2, S. Chiappalupi^1|2, L. Salvadori^1|3, M. Paiella^1|2, K. Mangar⁴, A.M. Schmidt⁴, M. Muscaritoli⁵, F. Riuzzi^1|2, G. Sorci^1|2 | ¹Department of Medicine and Surgery, University of Perugia, Perugia, Italy; ²Interuniversity Institute of Myology (IIM), Perugia, Italy; ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; ⁴Department of Medicine, NYU Grossman School of Medicine, New York, USA; ⁵Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; Giulia Gentili and S. Chiappalupi contributed equally; F. Riuzzi and G. Sorci Shared Senior authorship.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15490

  92