A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve

Submitted: 29 May 2016
Accepted: 17 October 2017
Published: 5 December 2017
Abstract Views: 998
PDF: 540
HTML: 172
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.


The transcriptional activator TAT is a small peptide essential for viral replication and possesses the property of entering the cells from the extracellular milieu, acting as a membrane shuttle. In order to safely differentiate cells an innovative methodology, based on the fusion of transcription factors and the TAT sequence, is discussed in this short review. In several studies, it has been demonstrated that TAT protein can be observed in the cell nucleus after few hours from the inoculation although its way of action is not fully understood. However, further studies will be necessary to develop this methodology for clinical purposes.



PlumX Metrics


Download data is not yet available.


How to Cite

Patruno, M., Melotti, L., Gomiero, C., Sacchetto, R., Topel, O., & Martinello, T. (2017). A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve. European Journal of Translational Myology, 27(4). https://doi.org/10.4081/ejtm.2017.6039