https://doi.org/10.4081/ejtm.2017.6039

A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve

Vol 27, No 4 (2017)
Submitted: 29 May 2016
Accepted: 17 October 2017
Published: 5 December 2017
Tat-MyoD, C2C12, PB-MSCs, coculture, myogenic induction
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Authors

Marco Patruno
marco.pat@unipd.it
Department of Comparative Biomedicine and Food Science, University of Padova, Italy.
Luca Melotti
Department of Comparative Biomedicine and Food Science, University of Padova, Italy.
Chiara Gomiero
Department of Comparative Biomedicine and Food Science, University of Padova, Italy.
Roberta Sacchetto
Department of Comparative Biomedicine and Food Science, University of Padova, Italy.
Ohad Topel
VTH - Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel.
Tiziana Martinello
Department of Comparative Biomedicine and Food Science, University of Padova, Italy.
The transcriptional activator TAT is a small peptide essential for viral replication and possesses the property of entering the cells from the extracellular milieu, acting as a membrane shuttle. In order to safely differentiate cells an innovative methodology, based on the fusion of transcription factors and the TAT sequence, is discussed in this short review. In several studies, it has been demonstrated that TAT protein can be observed in the cell nucleus after few hours from the inoculation although its way of action is not fully understood. However, further studies will be necessary to develop this methodology for clinical purposes.

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How to Cite

Patruno, M., Melotti, L., Gomiero, C., Sacchetto, R., Topel, O., & Martinello, T. (2017). A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve. European Journal of Translational Myology, 27(4). https://doi.org/10.4081/ejtm.2017.6039

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