Platelets-rich-plasma in management of non operative post cruciate ligament injury


Submitted: 22 June 2023
Accepted: 18 October 2023
Published: 18 December 2023
Abstract Views: 2016
PDF: 238
HTML: 3
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Posterior cruciate ligament (PCL) injury is a rare ligamentous knee injury which most commonly occurs due to direct trauma; it represents only 0.65% of knee injuries. On the basis of magnetic resonance imaging (MRI), PCL injury is divided into surgical and non-surgical. In the last few years we have witnessed an increasing interest in regenerative medicine. The use of innovative techniques allow the reduction of rehabilitation times in sports injuries. Platelet-Rich-Plasma (PRP) is a plasma-derived which stimulate the tissue repair. The objective of our work is to compare the rehabilitation times in PCL non-operative injuries treated with standard conservative treatment and PCL injuries treated with autologous PRP followed by rehabilitation program. We divided patients into two different groups: Group A formed by patients who underwent a standard conservative rehabilitation program and Group B which included patients treated by ultrasound guided PRP injection and following physiotherapy program. Both groups of patients resumed sports activities; however the rehabilitation times for patients which had undergone treatment with autologous PRP injection were reduced compared to patients who underwent a standard conservative treatment.


Majewski M, Susanne H, Klaus S. Epidemiology of athletic knee injuries: A 10-year study. Knee. 2006 Jun;13(3):184-8. Epub 2006 Apr 17. PMID: 16603363. DOI: https://doi.org/10.1016/j.knee.2006.01.005

Pache S, Aman ZS, Kennedy M, Nakama GY, Moatshe G, Ziegler C, LaPrade RF. Posterior Cruciate Ligament: Current Concepts Review. Arch Bone Jt Surg. 2018 Jan;6(1):8-18. PMID: 29430489; PMCID: PMC5799606.

La Fleur P, Argáez C. Platelet-Rich Plasma Injections for Wound Healing and Tissue Rejuvenation: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Jun 13. PMID: 30188645.

Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014 May 8;4(1):3-9. PMID: 24932440; PMCID: PMC4049647. DOI: https://doi.org/10.11138/mltj/2014.4.1.0013

Fang J, Wang X, Jiang W, Zhu Y, Hu Y, Zhao Y, Song X, Zhao J, Zhang W, Peng J, Wang Y. Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries. Tissue Eng Part B Rev. 2020 Dec;26(6):571-585. Epub 2020 Nov 3. PMID: 32380937; PMCID: PMC9208862. DOI: https://doi.org/10.1089/ten.teb.2019.0292

Collins T, Alexander D, Barkatali B. Platelet-rich plasma: a narrative review. EFORT Open Rev. 2021 Apr 1;6(4):225-235. PMID: 34040800; PMCID: PMC8142058. DOI: https://doi.org/10.1302/2058-5241.6.200017

de Melo F, Carrijo A, Hong K, Trumbic B, Vercesi F, Waldorf HA, Zenker S. Minimally Invasive Aesthetic Treatment of the Face and Neck Using Combinations of a PCL-Based Collagen Stimulator, PLLA/PLGA Suspension Sutures, and Cross-Linked Hyaluronic Acid. Clin Cosmet Investig Dermatol. 2020 May 5;13:333-344. PMID: 32440186; PMCID: PMC7211299. DOI: https://doi.org/10.2147/CCID.S248280

Braun HJ, Wasterlain AS, Dragoo JL. The use of PRP in ligament and meniscal healing. Sports Med Arthrosc Rev. 2013 Dec;21(4):206-12. PMID: 2421368. DOI: https://doi.org/10.1097/JSA.0000000000000005

Chen X, Jones IA, Park C, Vangsness CT Jr. The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-analysis With Bias Assessment. Am J Sports Med. 2018 Jul;46(8):2020-2032. Epub 2017 Dec 21. PMID: 29268037; PMCID: PMC6339617. DOI: https://doi.org/10.1177/0363546517743746

Keller PM, Shelbourne KD, McCarroll JR, Rettig AC. Nonoperatively treated isolated posterior cruciate ligament injuries. Am J Sports Med. 1993 Jan-Feb;21(1):132-6. PMID: 8427355. DOI: https://doi.org/10.1177/036354659302100122

Wang D, Graziano J, Williams RJ 3rd, Jones KJ. Nonoperative Treatment of PCL Injuries: Goals of Rehabilitation and the Natural History of Conservative Care. Curr Rev Musculoskelet Med. 2018 Jun;11(2):290-297. PMID: 29721691; PMCID: PMC5970122. DOI: https://doi.org/10.1007/s12178-018-9487-y

Valent A, Zati A. Terapie Fisiche, nuove tecnologie in Medicina Riabilitativa. 2017; 184-188.

Lee BK, Nam SW. Rupture of posterior cruciate ligament: diagnosis and treatment principles. Knee Surg Relat Res. 2011 Sep;23(3):135-41. Epub 2011 Sep 26. PMID: 22570824; PMCID: PMC3341837. DOI: https://doi.org/10.5792/ksrr.2011.23.3.135

Hajouj E, Hadian MR, Mir SM, Talebian S, Ghazi S. Effects of Innovative Aquatic Proprioceptive Training on Knee Proprioception in Athletes with Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial. Arch Bone Jt Surg. 2021 Sep;9(5):519-526. PMID: 34692934; PMCID: PMC8503762.

Mantia R, Vetro A, Di Gesù M, Iovane A, Midiri M, Caruso C, Mantia R. Isolated PCL injuries in young football players: new therapeutics approach with platelet rich plasma. XXI International Conference on Sports Rehabilitation and Traumatology. London 2012– Eds. Roy G.S., Della Villa S.- 2012

Winkler PW, Zsidai B, Wagala NN, Hughes JD, Horvath A, Senorski EH, Samuelsson K, Musahl V. Evolving evidence in the treatment of primary and recurrent posterior cruciate ligament injuries, part 1: anatomy, biomechanics and diagnostics. Knee Surg Sports Traumatol Arthrosc. 2021 Mar;29(3):672-681. Epub 2020 Nov 17. PMID: 33201271; PMCID: PMC7917041. DOI: https://doi.org/10.1007/s00167-020-06357-y

Pierce CM, O'Brien L, Griffin LW, Laprade RF. Posterior cruciate ligament tears: functional and postoperative rehabilitation. Knee Surg Sports Traumatol Arthrosc. 2013 May;21(5):1071-84. Epub 2012 Apr 8. PMID: 22484415. DOI: https://doi.org/10.1007/s00167-012-1970-1

Messina, G., Cataldo, P., Mantia, F., Iovane, E. M., Mantia, C., Terrasi, M., & Iovane, A. (2023). Platelets-rich-plasma in management of non operative post cruciate ligament injury. European Journal of Translational Myology, 34(1). https://doi.org/10.4081/ejtm.2023.11535

Downloads

Download data is not yet available.

Citations