A Design Method for FES Bone Health Therapy in SCI


Submitted: 25 November 2016
Accepted: 25 November 2016
Published: 15 December 2016
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Authors

  • Brian Andrews Department of Bio-Engineering at the University of Reading; The Nuffield Department of Surgical Sciences, Oxford, United Kingdom.
  • James Shippen Department of Industrial Design, Coventry University, United Kingdom.
  • Monica Armengol Department of Bio-Engineering at the University of Reading, United Kingdom.
  • Robin Gibbons Aspire CREATe group University College London, United Kingdom.
  • William Holderbaum Science and Engineering, Manchester Metropolitan University, United Kingdom.
  • William Harwin Department of Bio-Engineering at the University of Reading, United Kingdom.
FES assisted activities such as standing, walking, cycling and rowing induce forces within the leg bones and have been proposed to reduce osteoporosis in spinal cord injury (SCI). However, details of the applied mechanical stimulus for osteogenesis is often not reported. Typically, comparisons of bone density results are made after costly and time consuming clinical trials. These studies have produced inconsistent results and are subject to sample size variations. Here we propose a design process that may be used to predict the clinical outcome based on biomechanical simulation and mechano-biology. This method may allow candidate therapies to be optimized and quantitatively compared. To illustrate the approach we have used data obtained from a rower with complete paraplegia using the RowStim (III) system.

Andrews, B., Shippen, J., Armengol, M., Gibbons, R., Holderbaum, W., & Harwin, W. (2016). A Design Method for FES Bone Health Therapy in SCI. European Journal of Translational Myology, 26(4). https://doi.org/10.4081/ejtm.2016.6419

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