Reviews
Vol. 25 No. 4 (2015): Mobility in Elderly
https://doi.org/10.4081/ejtm.2015.5243

Electrical stimulation enhances reinnervation after nerve injury

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Received: 18 April 2015
Published: 24 August 2015
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Electrical muscle stimulation, Nerve injury, Axon sprouting, Motor unit number estimation, Intramuscular neurotrophic factors
biomedical engineering, neuroscience

Authors

Michael P. Willand
mikewilland@gmail.com
http://orcid.org/0000-0003-3421-8748 (unauthenticated)
Department of Surgery, Division of Plastic Reconstructive Surgery. The Hospital for Sick Children, Toronto, Canada.
Electrical muscle stimulation following peripheral nerve injury has been a controversial method of treatment due primarily to the inconsistent literature surrounding it. In this presentation transcript I outline ongoing experiments investigating a clinically translatable daily muscle stimulation paradigm in rats following nerve injury. Results show that reinnervation of muscle and functional behavioural metrics are enhanced with daily stimulation with upregulation of intramuscular neurotrophic factors as a potential mechanism. In addition, the impact of stimulation on terminal sprouting, a mentioned negative aspect of electrical muscle stimulation, was a minor contributor to long term functional reinnervation of stimulated muscles in our studies.

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1.
Willand MP. Electrical stimulation enhances reinnervation after nerve injury. Eur J Transl Myol [Internet]. 2015 Aug. 24 [cited 2026 May 3];25(4):243-8. Available from: https://www.pagepressjournals.org/bam/article/view/bam.2015.4.243

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