https://doi.org/10.4081/jbr.2026.15884
Current challenges in biology and clinical medicine: Journal of Biological Research – Bollettino della Società Italiana di Biologia Sperimentale, Vol. 99, issue 1, 2026
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 30 June 2026
Biological research is moving away from isolated observations. The current priority is integrating different layers of data to build practical interventions. Whether dealing with a metabolic diseases, an environmental crisis, or drug resistance, we need a combination of early diagnostic tools and targeted therapies. The papers published in this issue of the Journal of Biological Research focus precisely on this transition, covering clinical medicine, toxicology, and environmental biotechnology.
Early screening remains the most effective way to prevent irreversible tissue damage. This is clear in the study on type 2 diabetic nephropathy.¹ Microalbuminuria has well-known analytical limits, which is why attention is shifting to serum cystatin C and beta-2 microglobulin. Evaluating these two markers alongside the estimated glomerular filtration rate gives clinicians a much tighter window for early intervention.¹ Diagnostic accuracy is equally critical when managing thyroid nodules.² A direct comparison between the American Thyroid Association (ATA) guidelines and the ACR TI-RADS lexicon shows how standardizing ultrasound data reduces ambiguity in fine-needle aspiration decisions.² [...]
Downloads
1. Boukrous H, Derghal R, Mezhoud I, et al. Role of cystatin C and beta-2 microglobulin in the diagnosis of type 2 diabetic nephropathy. J Biol Res 2026;99:13476. DOI: https://doi.org/10.4081/jbr.2025.13476
2. Al-Waeli DK, Mohammed AG, Odhaib SA, Altemimi MT. Thyroid nodules stratification by American Thyroid Association and American College of Radiology lexicons: Thi-qar study. J Biol Res 2026;99:14148. DOI: https://doi.org/10.4081/jbr.2026.14148
3. Hasa A, Shpata V, Gjata A, et al. Correlation of prognostic biomarkers with histologic features in Albanian women with breast cancer. J Biol Res 2026:99:13977. DOI: https://doi.org/10.4081/jbr.2026.13977
4. Sergi M, Fazzino MF, Zanghì GN, et al. Primary breast Ewing sarcoma in a young adult: diagnostic challenges and neoadjuvant chemotherapy success. J Biol Res 2026:99:14434. DOI: https://doi.org/10.4081/jbr.2026.14434
5. Korolova D, Parkhomenko A, Chernyshenko V et al. Interconnection between blood clotting and inflammatory response in patients with acute myocardial infarction. J Biol Res 2026:99:14122. DOI: https://doi.org/10.4081/jbr.2025.14122
6. Ateş O, Kiraz Y. Unraveling bortezomib resistance in multiple myeloma: insights from RNA-Seq and PI3K/mTOR pathway analysis. J Biol Res 2026;99:14187. DOI: https://doi.org/10.4081/jbr.2026.14187
7. Venturella F, Marino G, Pinto A. The evolving science of Clesrovimab: pharmacological insights and clinical implications. J Biol Res 2026;99:14042. DOI: https://doi.org/10.4081/jbr.2026.14042
8. Meirawan RF, Veterini L, Sulistiyorini D, Oktaviana BM. Sexual behavior as a risk factor for T. Gondii infection in HIV patients J Biol Res 2026;99:14781. DOI: https://doi.org/10.4081/jbr.2026.13781
9. Giammanco M, Pitruzzella A, Giammanco MM, et al. Vitamin K and osteoporosis. J Biol Res 2026;99:14090. DOI: https://doi.org/10.4081/jbr.2026.14090
10. Dzevulska I, Huet A, Raksha N, et al. Inflammatory and stress biomarker changes in rat liver after Leiurus macroctenus envenomation. J Biol Res 2026;99:14851. DOI: https://doi.org/10.4081/jbr.2026.14851
11. Martorana M, Venturella F. Magnolia officinalis: botanical characteristics, pharmacological properties and current evidence from preclinical studies. J Biol Res 2026;99:14131. DOI: https://doi.org/10.4081/jbr.2026.14131
12. Goudarzi S, Akbarnejad Z, Mohseni M, et al. Effectiveness of intratympanic Epigallocatechin-3-gallate injection on Cisplatin-induced hearing loss in rats. J Biol Res 2026;99:14692. DOI: https://doi.org/10.4081/jbr.2025.13692
13. Turkustani AM. Grape seed oil protects against phenylhydrazine-induced hemolysis in rats. J Biol Res 2026;99:14262. DOI: https://doi.org/10.4081/jbr.2026.14262
14. Khoshnazar SM, Nejad SK, Dabiri S, et al. Geraniol alleviates liver ischemia/reperfusion injury by modulating the MAPK/NF-κB signaling pathway. J Biol Res 2026;99:13866. DOI: https://doi.org/10.4081/jbr.2026.13866
15. D'Urso F, Paladini F, Chieppa M, et al. A randomized, double-blind pilot study of a multi-strain probiotic formulation on depressive symptoms in adults. J Biol Res 2026;99:14692. DOI: https://doi.org/10.4081/jbr.2026.14692
16. D'Urso F, Paladini F, Scoditti E, et al. Effects of a strain-specific probiotic formulation on subjective sleep quality: a randomized, double-blind study. J Biol Res 2026;99:14689. DOI: https://doi.org/10.4081/jbr.2026.14689
17. Sguaizer F, Ferreri B, Tufo F, et al. Influence of urban and rural living environments on body measures, strength and lifestyle among first-year university students. J Biol Res 2026;99:14745. DOI: https://doi.org/10.4081/jbr.2026.14745
18. Hama Soor TA. Global reduction in animal morbidity and mortality due to vaccine development (1950–2021): rinderpest, foot-and-mouth disease, avian influenza, and rabies. J Biol Res 2026;99:14217. DOI: https://doi.org/10.4081/jbr.2026.14217
19. Lutzu GA, Concas A, Fais G, Dunford NT. Growth dynamics and pollutant removal efficiency of the cyanobacterium Komvophoron sp. in flowback and produced water: a pilot study. J Biol Res 2026;99:14241. DOI: https://doi.org/10.4081/jbr.2026.14241
20. Taleb N, Ait Amar-Berras S, Benoufella-Kitous K. Entomological survey of aphids natural enemies on two vegetable crops (Vicia faba and Solanum tuberosum) in the mountainous region of Kabylie (Iferhounène, Algeria). J Biol Res 2026;99:14439. DOI: https://doi.org/10.4081/jbr.2026.14439
CRediT authorship contribution
Supporting Agencies
Data Availability Statement
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.