Changes in the fecal profile of inflammatory markers after moderate consumption of red wine: a human trial study

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Irene Muñoz-González *
Irene Espinosa-Martos
Juan M. Rodríguez
Ana Jiménez-Girón
Pedro J. Martín-Álvarez
Begoña Bartolomé
Ma. Victoria Moreno-Arribas
(*) Corresponding Author:
Irene Muñoz-González |


The aim of this work was to evaluate the potential of moderate consumption of red wine to modulate the intestinal inflammation response on healthy humans. Fecal samples from a human intervention study (n=34) were collected before and after consumption of red wine for 4 weeks, and 24 immune markers including immunoglobulins, cytokines, chemokines and growth factors, were analysed. When considering the whole group of case volunteers, almost no statistically significant differences were found in the immune markers after wine consumption. However, a detailed exploration of the values differentiated a 6-volunteer subgroup that showed unusually high values of cytokines before wine consumption. For this subgroup, wine consumption significantly reduced the content of 16 out of 24 markers down to usual values, especially noticeable for cytokines related to the promotion of initial inflammation (tumor necrosis factor-alpha, interleukin 6 and interferon-gamma). This study reveals, for the first time, changes in the fecal profile of inflammatory markers after moderate consumption of red wine.

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Author Biography

Irene Muñoz-González, Instituto de Investigación en Ciencias de la Alimentación (CIAL), Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid



Prof. Matteo Bordiga

Journal of Wine Studies






Madrid, 31th October 2014


Dear Editor,


Please find enclosed the manuscript entitled “Changes in the fecal profile of inflammatory markers after moderate consumption of red wine. A human trial study”, by Irene Muñoz-González, Irene Espinosa-Martos, Juan M. Rodríguez, Ana Jiménez-Giron, Pedro J. Martín-Álvarez, Begoña Bartolomé, M. Victoria Moreno-Arribas.


This manuscript is submitted for your consideration for publication in in the Journal of Wine Studies.


This manuscript is an original contribution and it has never been published before. All the authors acknowledge their significant contribution to this paper and they agree with its submission for your consideration to be published.


We look forward to hearing from you.


Thank you.


Yours sincerely,


Dr M.Victoria Moreno-Arribas

CIAL- Institute of Food Science Research (CSIC-UAM)

c/ Nicolás Cabrera, 9. Campus de Cantoblanco.

28049 Madrid, SPAIN

Tel. + 34 91 0017902 – 607195887