Preventive effect of yacon leaves capsule in reducing symptoms of Exercise-Induced Muscle Damage

Published: 9 September 2024
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Exercise-Induced Muscle Damage (EIMD) is the disruption of skeletal muscle after high-intensity exercise, leading to decreased performance. Furthermore, it is a common condition following vigorous exercise, particularly in individuals unaccustomed to performance. This disruption results in a decrease in strength, muscle soreness, swelling, and the release of several cytokines, both inflammatory and anti-inflammatory. Symptoms of EIMD include Delayed-Onset Muscle Soreness (DOMS) and a loss of physical function. Therefore, this study aimed to investigate the effect of a 14-day administration of yacon leaves capsule supplementation on DOMS and inflammation post-EIMD.
To achieve this, an experimental pretest and posttest control group design with a randomized control trial approach was adopted. A total of 32 Recreational male students of the Sports Science Universitas Negeri Surabaya were randomly and double-blindly assigned to either yacon capsule supplementation (n=16) or placebo (n=16) group. Participants were instructed to take a yacon capsule or placebo after breakfast for 14 days. The study groups were subjected to a muscle-damaging protocol consisting of 7 sets of 10 eccentric single-leg press repetitions on a leg press machine. DOMS and Interleukin 6 (IL-6) were determined at 0-h (baseline), 24-h, and 48-h post-exercise before and after 14-day supplementation periods.
The results showed that DOMS and IL-6 serum increased at 24 hours post-EIMD when compared to baseline. Additionally, a significant reduction in both DOMS and IL-6 serum levels was observed within the yacon group compared to the placebo group (p<0.05).
In conclusion, yacon leaves capsule supplementation was able to attenuate the risk of muscle damage by decreasing DOMS levels and IL-6 serum in the blood.

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Sulistyarto S, Irawan R, Kumaat NA, Rimawati N. Correlation of Delayed Onset Muscle Soreness and Inflammation Post-exercise Induced Muscle Damage. Open Access Macedonian Journal of Medical Sciences. 2022 Jan 1;10(A):1688–94. DOI: https://doi.org/10.3889/oamjms.2022.10991
Sonkodi B. Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation. Biomolecules. 2022 Sep;12(9):1207. DOI: https://doi.org/10.3390/biom12091207
Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr. 2022 Dec;61(8):3835-3855. DOI: https://doi.org/10.1007/s00394-022-02943-7
Irawan R, Mahmudiono T, Martiana T. Interleukin-6 as Immune System and Inflammation Biomarker on the Response of Basic Pencak Silat Exercise in Perguruan Pencak Silat Perisai Diri, Bojonegoro. Open Access Macedonian Journal of Medical Sciences. 2021 Oct 31;9(T6):179–83. DOI: https://doi.org/10.3889/oamjms.2021.7303
Zulaini, Harahap NS, Siregar NS, Zulfahri. Effect Stretching and Recovery on Delayed Onset Muscle Soreness (DOMS) After Exercise. J Phys: Conf Ser. 2021 Mar;1811(1):012113. DOI: https://doi.org/10.1088/1742-6596/1811/1/012113
Kristensen NS, Hertel E, Skadhauge CH, Kronborg SH, Petersen KK, McPhee ME. Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise. PLoS One. 2021 Jul 30;16(7):e0253945. DOI: https://doi.org/10.1371/journal.pone.0253945
Heiss R, Lutter C, Freiwald J, Hoppe MW, Grim C, Poettgen K, Forst R, Bloch W, Hüttel M, Hotfiel T. Advances in Delayed-Onset Muscle Soreness (DOMS) - Part II: Treatment and Prevention. Sportverletz Sportschaden. 2019 Mar;33(1):21-29. DOI: https://doi.org/10.1055/a-0810-3516
Hotfiel T, Freiwald J, Hoppe MW, Lutter C, Forst R, Grim C, Bloch W, Hüttel M, Heiss R. Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics. Sportverletz Sportschaden. 2018 Dec;32(4):243-250. DOI: https://doi.org/10.1055/a-0753-1884
Udani JK, Singh BB, Singh VJ, Sandoval E. BounceBack capsules for reduction of DOMS after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study. J Int Soc Sports Nutr. 2009 Jun 5;6:14. DOI: https://doi.org/10.1186/1550-2783-6-14
Angelopoulos P, Diakoronas A, Panagiotopoulos D, Tsekoura M, Xaplanteri P, Koumoundourou D, Saki F, Billis E, Tsepis E, Fousekis K. Cold-Water Immersion and Sports Massage Can Improve Pain Sensation but Not Functionality in Athletes with Delayed Onset Muscle Soreness. Healthcare (Basel). 2022 Dec 5;10(12):2449. DOI: https://doi.org/10.3390/healthcare10122449
Wilke J, Behringer M. Is "Delayed Onset Muscle Soreness" a False Friend? The Potential Implication of the Fascial Connective Tissue in Post-Exercise Discomfort. Int J Mol Sci. 2021 Aug 31;22(17):9482. DOI: https://doi.org/10.3390/ijms22179482
Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports. 2019 Apr;29(4):524-534. DOI: https://doi.org/10.1111/sms.13373
Boukhris O, Trabelsi K, Abdessalem R, Hsouna H, Ammar A, Glenn JM, Bott N, Irandoust K, Taheri M, Turki M, Ayadi F, Bragazzi NL, Engel FA, Chtourou H. Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes. Int J Environ Res Public Health. 2020 Jun 18;17(12):4375. DOI: https://doi.org/10.3390/ijerph17124375
Nakhostin-Roohi B, Nasirvand Moradlou A, Mahmoodi Hamidabad S, Ghanivand B. The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS). Annals of Applied Sport Science. 2016 Jul 10;4(2):25–31. DOI: https://doi.org/10.18869/acadpub.aassjournal.4.2.25
Irawan RJ, Sulistyarto S, Rimawati N. Supplementation of Kencur (Kaempferia Galanga Linn) Extract on Malondealdehyde (MDA) and Interleukin-6 (IL-6) Plasma Levels Post Aerobic Training Activity: Suplementasi Ekstrak Kencur (Kaempferia Galanga linn) terhadap Kadar Plasma Malondealdehide (MDA) dan Interleukin-6 (IL-6) Pasca Aktivitas Latihan Aerobik . AMNT. 2022 Dec. 23;6(1SP):140-5. DOI: https://doi.org/10.20473/amnt.v6i1SP.2022.140-145
Rickards L, Lynn A, Harrop D, Barker ME, Russell M, Ranchordas MK. Effect of Polyphenol-Rich Foods, Juices, and Concentrates on Recovery from Exercise Induced Muscle Damage: A Systematic Review and Meta-Analysis. Nutrients. 2021 Aug 27;13(9):2988. DOI: https://doi.org/10.3390/nu13092988
Chen HY, Chen YC, Tung K, Chao HH, Wang HS. Effects of caffeine and sex on muscle performance and delayed-onset muscle soreness after exercise-induced muscle damage: a double-blind randomized trial. J Appl Physiol (1985). 2019 Sep 1;127(3):798-805. DOI: https://doi.org/10.1152/japplphysiol.01108.2018
Vaile J, Halson S, Gill N, Dawson B. Effect of hydrotherapy on the signs and symptoms of delayed onset muscle soreness. Eur J Appl Physiol. 2008 Mar;102(4):447-55. doi: 10.1007/s00421-007-0605-6. Epub 2007 Nov 3. Erratum in: Eur J Appl Physiol. 2008 May;103(1):121-2. DOI: https://doi.org/10.1007/s00421-007-0605-6
Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 2015 Aug;115(8):1769-77. DOI: https://doi.org/10.1007/s00421-015-3152-6
Gokhale R, Chandrashekara S, Vasanthakumar KC. Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. Cytokine. 2007 Nov;40(2):123-7. DOI: https://doi.org/10.1016/j.cyto.2007.08.006
Lamb KL, Ranchordas MK, Johnson E, Denning J, Downing F, Lynn A. No Effect of Tart Cherry Juice or Pomegranate Juice on Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men. Nutrients. 2019 Jul 14;11(7):1593. DOI: https://doi.org/10.3390/nu11071593
Chang WD, Lin HY, Chang NJ, Wu JH. Effects of 830 nm Light-Emitting Diode Therapy on Delayed-Onset Muscle Soreness. Evidence-Based Complementary and Alternative Medicine. 2021;2021(1):6690572. DOI: https://doi.org/10.1155/2021/6690572
Doma K, Burt D, Connor JD. The acute effect of a multi-modal plyometric training session on field-specific performance measures. J Sports Med Phys Fitness. 2021 Jul;61(7):899-906. DOI: https://doi.org/10.23736/S0022-4707.20.11603-7
Martínez-Ferrán M, Cuadrado-Peñafiel V, Sánchez-Andreo JM, Villar-Lucas M, Castellanos-Montealegre M, Rubio-Martín A, Romero-Morales C, Casla-Barrio S, Pareja-Galeano H. Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial. Nutrients. 2022 Nov 3;14(21):4635. DOI: https://doi.org/10.3390/nu14214635
Fleckenstein J, Neuberger EWI, Bormuth P, Comes F, Schneider A, Banzer W, Fischer L, Simon P. Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT. Front Physiol. 2021 Sep 16;12:697335.. DOI: https://doi.org/10.3389/fphys.2021.697335
Pyne DB. Exercise-induced muscle damage and inflammation: a review. Aust J Sci Med Sport. 1994 Sep-Dec;26(3-4):49-58.
Torre MF, Martinez-Ferran M, Vallecillo N, Jiménez SL, Romero-Morales C, Pareja-Galeano H. Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review. Antioxidants (Basel). 2021 Feb 12;10(2):279. DOI: https://doi.org/10.3390/antiox10020279
Connolly DA, Sayers SP, McHugh MP. Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res. 2003 Feb;17(1):197-208. DOI: https://doi.org/10.1519/00124278-200302000-00030
Sonkodi B, Hegedűs Á, Kopper B, Berkes I. Significantly Delayed Medium-Latency Response of the Stretch Reflex in Delayed-Onset Muscle Soreness of the Quadriceps Femoris Muscles Is Indicative of Sensory Neuronal Microdamage. J Funct Morphol Kinesiol. 2022 May 27;7(2):43. DOI: https://doi.org/10.3390/jfmk7020043
Barker GA, Parten AL, Lara DA, Hannon KE, McAllister MJ, Waldman HS. Astaxanthin Supplementation Reduces Subjective Markers of Muscle Soreness following Eccentric Exercise in Resistance-Trained Men. Muscles. 2023 Jun;2(2):228–37. DOI: https://doi.org/10.3390/muscles2020017
Tanabe Y, Fujii N, Suzuki K. Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans. Nutrients. 2021 Dec 24;14(1):70. DOI: https://doi.org/10.3390/nu14010070
Jamurtas AZ. Exercise-Induced Muscle Damage and Oxidative Stress. Antioxidants (Basel). 2018 Mar 28;7(4):50. DOI: https://doi.org/10.3390/antiox7040050
Lin CH, Lin YA, Chen SL, Hsu MC, Hsu CC. American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males. Nutrients. 2021 Dec 25;14(1):78. DOI: https://doi.org/10.3390/nu14010078
Andrade E, Ellendersen L, Masson M. Phenolic profile and antioxidant activity of extracts of leaves andflowers of yacon (Smallanthus sonchifolius). Industrial Crops and Products. 2014 Sep 14;62:499–506. DOI: https://doi.org/10.1016/j.indcrop.2014.09.025
Widowati W, Tjokropranoto R, Onggowidjaja P, Widya Kusuma HS, Wijayanti CR, Marthania M, Yati A, Rizal R. Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy. Res Pharm Sci. 2023 Mar 10;18(3):336-345. DOI: https://doi.org/10.4103/1735-5362.371589
Kim K, Lim Y, Oh JH, Park UK, Huh MK, Hwang SY. Antioxidant Effect of Mulberry Leaves and Yacon Tuber Extracts in High-fat Diet-fed Rats. Biomed Sci Letters. 2020 Sep 30;26(3):201–9. DOI: https://doi.org/10.15616/BSL.2020.26.3.201
Hachkova H, Nagalievska M, Soliljak Z, Kanyuka O, Kucharska AZ, Sokół-Łętowska A, Belonovskaya E, Buko V, Sybirna N. Medicinal Plants Galega officinalis L. and Yacon Leaves as Potential Sources of Antidiabetic Drugs. Antioxidants (Basel). 2021 Aug 26;10(9):1362. DOI: https://doi.org/10.3390/antiox10091362
Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 2020 Sep;9(5):415-425. DOI: https://doi.org/10.1016/j.jshs.2020.04.001
Jakubczyk K, Dec K, Kałduńska J, Kawczuga D, Kochman J, Janda K. Reactive oxygen species - sources, functions, oxidative damage. Pol Merkur Lekarski. 2020 Apr 22;48(284):124-127.
Gomez-Cabrera MC, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008 Jan 15;44(2):126-31. DOI: https://doi.org/10.1016/j.freeradbiomed.2007.02.001
Di Meo S, Napolitano G, Venditti P. Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage. Int J Mol Sci. 2019 Jun 20;20(12):3024. doi: 10.3390/ijms20123024. PMID: 31226872; PMCID: PMC6627449. DOI: https://doi.org/10.3390/ijms20123024
Northeast B, Clifford T. The Effect of Creatine Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Human Intervention Trials. Int J Sport Nutr Exerc Metab. 2021 May 1;31(3):276-291. DOI: https://doi.org/10.1123/ijsnem.2020-0282
Sara HS. Effects of Electrotherapy on Delayed Onset Muscle Soreness (DOMS). J Biomed Res Environ Sci. 2021 Sep;2(9):812–4. DOI: https://doi.org/10.37871/jbres1313
Lee MC, Jhang WL, Lee CC, Kan NW, Hsu YJ, Ho CS, Chang CH, Cheng YC, Lin JS, Huang CC. The Effect of Kefir Supplementation on Improving Human Endurance Exercise Performance and Antifatigue. Metabolites. 2021 Feb 25;11(3):136. DOI: https://doi.org/10.3390/metabo11030136
Cheung K, Hume P, Maxwell L. Delayed onset muscle soreness : treatment strategies and performance factors. Sports Med. 2003;33(2):145-64. DOI: https://doi.org/10.2165/00007256-200333020-00005
Mizumura K, Taguchi T. Delayed onset muscle soreness: Involvement of neurotrophic factors. J Physiol Sci. 2016 Jan;66(1):43-52. DOI: https://doi.org/10.1007/s12576-015-0397-0
Ferraz APCR, Garcia JL, Costa MR, Almeida CCVD, Gregolin CS, Alves PHR, et al. Yacon (Smallanthus sonchifolius) use as an antioxidant in diabetes. In: Pathology [Internet]. Elsevier; 2020 [cited 2023 Apr 10]. p. 379–86. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128159729000366. DOI: https://doi.org/10.1016/B978-0-12-815972-9.00036-6
Djalalinia S, Hasani M, Asayesh H, Ejtahed HS, Malmir H, Kasaeian A, Zarei M, Baygi F, Rastad H, Mahdavi Gorabi A, Qorbani M. The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord. 2021 Jun 9;20(1):1051-1062. DOI: https://doi.org/10.1007/s40200-021-00821-3

How to Cite

Irawan, R. J., Sudijandoko, A., Wahyudi, H., Kumaat, N. A., Bawono, M. N., Rimawati, N., & Wijayanto, A. (2024). Preventive effect of yacon leaves capsule in reducing symptoms of Exercise-Induced Muscle Damage. Healthcare in Low-Resource Settings. https://doi.org/10.4081/hls.2024.13031