4th International Nursing and Health Sciences Symposium Open access

Preventive effect of yacon leaves capsule in reducing symptoms of Exercise-Induced Muscle Damage

Authors

Published
9 September 2024
Section
4th International Nursing and Health Sciences Symposium
DOI
10.4081/hls.2024.13031

Abstract

Exercise-Induced Muscle Damage (EIMD) is the disruption of skeletal muscle after high-intensity exercise, leading to decreased performance. Furthermore, it is a common condition following vigorous exercise, particularly in individuals unaccustomed to performance. This disruption results in a decrease in strength, muscle soreness, swelling, and the release of several cytokines, both inflammatory and anti-inflammatory. Symptoms of EIMD include Delayed-Onset Muscle Soreness (DOMS) and a loss of physical function. Therefore, this study aimed to investigate the effect of a 14-day administration of yacon leaves capsule supplementation on DOMS and inflammation post-EIMD. To achieve this, an experimental pretest and posttest control group design with a randomized control trial approach was adopted. A total of 32 Recreational male students of the Sports Science Universitas Negeri Surabaya were randomly and double-blindly assigned to either yacon capsule supplementation (n=16) or placebo (n=16) group. Participants were instructed to take a yacon capsule or placebo after breakfast for 14 days. The study groups were subjected to a muscle-damaging protocol consisting of 7 sets of 10 eccentric single-leg press repetitions on a leg press machine. DOMS and Interleukin 6 (IL-6) were determined at 0-h (baseline), 24-h, and 48-h post-exercise before and after 14-day supplementation periods. The results showed that DOMS and IL-6 serum increased at 24 hours post-EIMD when compared to baseline. Additionally, a significant reduction in both DOMS and IL-6 serum levels was observed within the yacon group compared to the placebo group (p<0.05). In conclusion, yacon leaves capsule supplementation was able to attenuate the risk of muscle damage by decreasing DOMS levels and IL-6 serum in the blood.

Keywords

References

  1. Sulistyarto S, Irawan R, Kumaat NA, Rimawati N. Correlation of Delayed Onset Muscle Soreness and Inflammation Post-exercise Induced Muscle Damage. Open Access Macedonian J Med Sc 2022 Jan 1;10(A):1688–94.
  2. Sonkodi B. Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation. Biomolecules 2022;12:1207.
  3. Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr 2022;61:3835-3855.
  4. Irawan R, Mahmudiono T, Martiana T. Interleukin-6 as Immune System and Inflammation Biomarker on the Response of Basic Pencak Silat Exercise in Perguruan Pencak Silat Perisai Diri, Bojonegoro. Open Access Macedonian J Med Sci 2021;9:179–83.
  5. Zulaini, Harahap NS, Siregar NS, Zulfahri. Effect Stretching and Recovery on Delayed Onset Muscle Soreness (DOMS) After Exercise. J Phys: Conf Ser 2021;1811:012113.
  6. Kristensen NS, Hertel E, Skadhauge CH, et al. Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise. PLoS One 2021;16:e0253945.
  7. Heiss R, Lutter C, Freiwald J, et al. Advances in Delayed-Onset Muscle Soreness (DOMS) - Part II: Treatment and Prevention. Sportverletz Sportschaden 2019;33:21-9.
  8. Hotfiel T, Freiwald J, Hoppe MW, et al. Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics. Sportverletz Sportschaden 2018;32:243-250.
  9. Udani JK, Singh BB, Singh VJ, Sandoval E. BounceBack capsules for reduction of DOMS after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study. J Int Soc Sports Nutr 2009;6:14.
  10. Angelopoulos P, Diakoronas A, Panagiotopoulos D, et al. Cold-Water Immersion and Sports Massage Can Improve Pain Sensation but Not Functionality in Athletes with Delayed Onset Muscle Soreness. Healthcare (Basel) 2022;10:2449.
  11. Wilke J, Behringer M. Is "Delayed Onset Muscle Soreness" a False Friend? The Potential Implication of the Fascial Connective Tissue in Post-Exercise Discomfort. Int J Mol Sci 2021;22:9482.
  12. Tanabe Y, Chino K, Ohnishi T, et al. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports 2019;29:524-34.
  13. Boukhris O, Trabelsi K, Abdessalem R, et al. Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes. Int J Environ Res Public Health 2020;17:4375.
  14. Nakhostin-Roohi B, Nasirvand Moradlou A, Mahmoodi Hamidabad S, Ghanivand B. The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS). Ann Appl Sport Sci 2016;4:25–31.
  15. Irawan RJ, Sulistyarto S, Rimawati N. Supplementation of Kencur (Kaempferia Galanga Linn) Extract on Malondealdehyde (MDA) and Interleukin-6 (IL-6) Plasma Levels Post Aerobic Training Activity: Suplementasi Ekstrak Kencur (Kaempferia Galanga linn) terhadap Kadar Plasma Malondealdehide (MDA) dan Interleukin-6 (IL-6) Pasca Aktivitas Latihan Aerobik. AMNT 2022;6:140-5.
  16. Rickards L, Lynn A, Harrop D, et al. Effect of Polyphenol-Rich Foods, Juices, and Concentrates on Recovery from Exercise Induced Muscle Damage: A Systematic Review and Meta-Analysis. Nutrients 2021;13:2988.
  17. Chen HY, Chen YC, Tung K, et al. Effects of caffeine and sex on muscle performance and delayed-onset muscle soreness after exercise-induced muscle damage: a double-blind randomized trial. J Appl Physiol (1985) 2019;127:798-805.
  18. Vaile J, Halson S, Gill N, Dawson B. Effect of hydrotherapy on the signs and symptoms of delayed onset muscle soreness. Eur J Appl Physiol 2008;102:447-55. Erratum in: Eur J Appl Physiol 2008;103:121-2.
  19. Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol 2015;115:1769-77.
  20. Gokhale R, Chandrashekara S, Vasanthakumar KC. Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. Cytokine 2007;40:123-7.
  21. Lamb KL, Ranchordas MK, Johnson E, et al. No Effect of Tart Cherry Juice or Pomegranate Juice on Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men. Nutrients 2019;11:1593.
  22. Chang WD, Lin HY, Chang NJ, Wu JH. Effects of 830 nm Light-Emitting Diode Therapy on Delayed-Onset Muscle Soreness. Evidence-Based Complement Alternat Med 2021;2021:6690572.
  23. Doma K, Burt D, Connor JD. The acute effect of a multi-modal plyometric training session on field-specific performance measures. J Sports Med Phys Fitness 2021;61:899-906.
  24. Martínez-Ferrán M, Cuadrado-Peñafiel V, Sánchez-Andreo JM, et al. Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial. Nutrients 2022;14:4635.
  25. Fleckenstein J, Neuberger EWI, Bormuth P, et al. Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT. Front Physiol 2021;12:697335.
  26. Pyne DB. Exercise-induced muscle damage and inflammation: a review. Aust J Sci Med Sport 1994;26:49-58.
  27. Torre MF, Martinez-Ferran M, Vallecillo N, et al. Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review. Antioxidants (Basel) 2021;10:279.
  28. Connolly DA, Sayers SP, McHugh MP. Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res 2003;17:197-208.
  29. Sonkodi B, Hegedűs Á, Kopper B, Berkes I. Significantly Delayed Medium-Latency Response of the Stretch Reflex in Delayed-Onset Muscle Soreness of the Quadriceps Femoris Muscles Is Indicative of Sensory Neuronal Microdamage. J Funct Morphol Kinesiol 2022;7:43.
  30. Barker GA, Parten AL, Lara DA, et al. Astaxanthin Supplementation Reduces Subjective Markers of Muscle Soreness following Eccentric Exercise in Resistance-Trained Men. Muscles 2023;2:228–37.
  31. Tanabe Y, Fujii N, Suzuki K. Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans. Nutrients 2021;14:70.
  32. Jamurtas AZ. Exercise-Induced Muscle Damage and Oxidative Stress. Antioxidants (Basel) 2018;7:50.
  33. Lin CH, Lin YA, Chen SL, et al. American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males. Nutrients 2021;14:78.
  34. Andrade E, Ellendersen L, Masson M. Phenolic profile and antioxidant activity of extracts of leaves andflowers of yacon (Smallanthus sonchifolius). Industrial Crops Products 2014;62:499–506.
  35. Widowati W, Tjokropranoto R, Onggowidjaja P, et al. Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy. Res Pharm Sci 2023;18:336-45.
  36. Kim K, Lim Y, Oh JH, et al. Antioxidant Effect of Mulberry Leaves and Yacon Tuber Extracts in High-fat Diet-fed Rats. Biomed Sci Letters 2020;26:201–9.
  37. Hachkova H, Nagalievska M, Soliljak Z, et al. Medicinal Plants Galega officinalis L. and Yacon Leaves as Potential Sources of Antidiabetic Drugs. Antioxidants (Basel) 2021;10:1362.
  38. Powers SK, Deminice R, Ozdemir M, et al. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci 2020;9:415-25.
  39. Jakubczyk K, Dec K, Kałduńska J, et al. Reactive oxygen species - sources, functions, oxidative damage. Pol Merkur Lekarski 2020;48:124-7.
  40. Gomez-Cabrera MC, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med 2008;44:126-31.
  41. Di Meo S, Napolitano G, Venditti P. Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage. Int J Mol Sci 2019;20:3024.
  42. Northeast B, Clifford T. The Effect of Creatine Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Human Intervention Trials. Int J Sport Nutr Exerc Metab 2021;31:276-291.
  43. Sara HS. Effects of Electrotherapy on Delayed Onset Muscle Soreness (DOMS). J Biomed Res Environ Sci 2021;2:812–4.
  44. Lee MC, Jhang WL, Lee CC, et al. The Effect of Kefir Supplementation on Improving Human Endurance Exercise Performance and Antifatigue. Metabolites 2021;11:136.
  45. Cheung K, Hume P, Maxwell L. Delayed onset muscle soreness : treatment strategies and performance factors. Sports Med 2003;33:145-64.
  46. Mizumura K, Taguchi T. Delayed onset muscle soreness: Involvement of neurotrophic factors. J Physiol Sci 2016;66:43-52.
  47. Ferraz APCR, Garcia JL, Costa MR, et al. Yacon (Smallanthus sonchifolius) use as an antioxidant in diabetes. In: Pathology Elsevier; 2020 [cited 2023 Apr 10]. p. 379–86. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128159729000366.
  48. Djalalinia S, Hasani M, Asayesh H, et al. The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord 2021;20:1051-62.

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