Original Articles
Vol. 11 No. 1 (2023)
https://doi.org/10.4081/hls.2023.11229

Prevalence of MLSB Phenotypes of Staphylococcus aureus isolates in a tertiary care hospital of Delhi

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Received: 31 January 2023
Accepted: 7 June 2023
Published: 15 June 2023
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Staphylococcus aureus, inducible clindamycin resistance, constitutive clindamycin resistance, MSB phenotype

Authors

Malika Grover
Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Nisha Goyal
drnishagoyalucms@gmail.com
Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Seema Gangar
Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Narendra Pal Singh
https://orcid.org/0000-0002-3302-3749
Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.

Against the backdrop of the ever-changing Staphylococcal resistance pattern, clindamycin remains a viable therapeutic alternative Variation of Clindamycin drug resistance patterns with geographic area make inducible clindamycin resistance testing imperative for all staphylococcal isolates to avoid therapeutic failure. This was a prospective study conducted over a period of 1.5 years from January 2021 until June 2022. Prevalence of different MLSB Phenotypes of Staphylococcus aureus isolates was determined by standard disc diffusion method as per CLSI guidelines. Pyogenic samples received in the Microbiology lab that yielded Staphylococcus aureus were further tested for the presence of clindamycin resistance by disc diffusion method. Out of 6586 total pyogenic and respiratory specimens received in the lab, Staphylococcus aureus was yielded in 752 samples. On further testing for the MLSB phenotypes, 16.3% isolates were found to be iMLSB, 19.28% were cMLSB, 43.1% were of MSB type. ICR screening will reduce the unessential subjection of the patient to the antibiotic, and would prevent unnecessary adverse effects in the patients.

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Prevalence of MLSB Phenotypes of Staphylococcus aureus isolates in a tertiary care hospital of Delhi. (2023). Healthcare in Low-Resource Settings, 11(1). https://doi.org/10.4081/hls.2023.11229
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