Original Articles
Vol. 2 No. 1 (2016)
https://doi.org/10.4081/gc.2016.5722

The effect of erythropoietin on calcium levels during hypoxia reoxygenation injury in rats

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Received: 31 December 2015
Published: 14 April 2016
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Hypoxia, erythropoietin, calcium, reoxygenation, hypocalcemia, dyscalcemia, hypercalcemia.
Geriatric Care, Elderly, Geriatrics

Authors

Constantinos Tsompos
tsomposconstantinos@gmail.com
Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece.
Constantinos Panoulis
Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece.
Konstantinos Toutouzas
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece.
Aggeliki Triantafyllou
Department of Biologic Chemistry, Athens University, Attiki, Greece.
George Zografos
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece.
Apostolos Papalois
Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co. Attiki, Greece.
This experimental study examined the effect of erythropoietin (Epo) on rat model and particularly in a hypoxia-reoxygenation protocol. The effect of that molecule was studied biochemically using blood mean calcium levels (Ca++). Forty rats of mean weight 247.7 g were used in the study. Ca++ levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. Erythropoietin was administered only in groups C and D. Epo administration non-significantly decreased the Ca++ levels by 0.56%±1.13% (P=0.5761). Reoxygenation time non-significantly increased the Ca++ levels by 0.65%±1.12% (P=0.5281). However, Epo administration and reoxygenation time together non-significantly decreased the Ca++ levels by 0.34%±0.68% (P=0.6095). Epo administration whether it interacted or not with reoxygenation time had non-significant decreasing short-term effects on calcium levels. Perhaps, a longer study time than 2 h or a higher Epo dose may reveal more significant effects.

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Supporting Agencies

Acknowledgment, This study was funded by Scholarship by the Experimental Research Center ELPEN Pharmaceuticals (E.R.C.E), Athens, Greece. The research facilities for this project were provided by the aforementioned institution.

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The effect of erythropoietin on calcium levels during hypoxia reoxygenation injury in rats. (2016). Geriatric Care, 2(1). https://doi.org/10.4081/gc.2016.5722

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