The impact of glomerular filtration rate on short-term outcome in elderly patients with heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction is a frequent condition among the elderly. The prevalence of chronic kidney disease is also very high, accounting for 5-10% of the population. The aim of this study was to investigate whether the decrease in renal function, assessed by estimated glomerular filtration rate (eGFR), was an independent predictor of adverse events such as death and new hospitalizations in elderly patients hospitalized with heart failure with preserved ejection fraction. This study included hospitalized patients diagnosed with heart failure with preserved ejection fraction. Renal function was estimated by calculating glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration formula. Patients were stratified into two cohorts using the median eGFR value of 45.45 mL/min/1.73 m2 as the cutoff. During a 3-month follow-up, a total of 30 events were recorded. Multivariate logistic analysis adjusted for confounding factors such as age, gender, anemia, and therapy revealed that eGFR was an independent predictive factor in various models: odds ratio (OR): 0.96, 95% confidence interval (CI) 0.93-0.99, p=0.016; OR: 0.95, 95% CI 0.93-0.98, p=0.003. GFR is an independent predictive factor of short-term events in a population of elderly patients with heart failure with preserved ejection fraction.