https://doi.org/10.4081/aiua.2026.15544
Mazindol to induce antegrade ejaculation in a patient with aspermia secondary to diabetic neuropathy
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 29 May 2026
To the Editor,
Erection and ejaculation are necessary processes for semen to be deposited naturally in the vagina, allowing sperm to migrate in search of the egg in the female reproductive tract and achieve fertilization. However, in some cases, complete retrograde ejaculation (with absence of ejaculation – aspermia) or partial retrograde ejaculation (decreased seminal volume – hypospermia – and sperm concentration – oligozoospermia) may occur. In cases of aspermia or anejaculation, retrograde ejaculation should be suspected, and the diagnosis is confirmed by finding sperm in the post-ejaculatory urine [...].
Downloads
1. Belladelli F, Pozzi E, Fallara G, et al. Orgasm and ejaculation disorders. Practical Clinical Andrology. Springer International Publishing Cham. 2022; 75-87.
2. Jefferys A, Siassakos D, Wardle P. The management of retrograde ejaculation: a systematic review and update. Fertil Steril. 2012; 97:306-312.
3. Fedder J, Kaspersen MD, Brandslund I, Hojgaard A. Retrograde ejaculation and sexual dysfunction in men with diabetes mellitus: a prospective, controlled study. Andrology. 2013; 1:602-606.
4. Sibona M, Destefanis P, Vercelli E, et al. Ejaculation physiology and dysfunction after BPH surgery: the role of the new MISTs. Prostate Cancer Prostatic Dis. 2023; 26:475-482.
5. Gupta S, Sharma R, Agarwal A, et al. A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation. World J Mens Health. 2022; 40:208-216.
6. Adel Domínguez A, Cardona Maya W, Mora Topete A: Mazindol as a temporary treatment for patients with retrograde ejaculation: case series. Asian Journal of Urology. In press 2026.
7. World Health Organization: WHO Laboratory Manual for the Examination and Processing of Human Semen. 2021.
8. Konstantinidis C, Zachariou A, Evgeni E, et al. Recent Advances in the Diagnosis and Management of Retrograde Ejaculation: A Narrative Review. Diagnostics (Basel). 2025; 15.
Supporting Agencies
Data Availability Statement
Not applicable.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.