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Non-invasive assessment of gastric secretory function in centenarians

Antonio Tursi, Rudi De Bastiani, Marilisa Franceschi, Elisabetta Goni, Matteo Riccò, Marino Venerito, Massimo Rugge, Carmelo Scarpignato, Marcello Picchio, Francesco Di Mario, the Primary Care collaborative group
  • Rudi De Bastiani
    Primary Care Setting, Veneto Region, Italy
  • Marilisa Franceschi
    Digestive Endoscopy Unit, ULSS4 Alto Vicentino, Santorso, Schio (VI), Italy
  • Elisabetta Goni
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany
  • Matteo Riccò
    Department of Health Prevention, Occupational Health & Search Unit, Trento, Italy
  • Marino Venerito
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany
  • Massimo Rugge
    Department of Pathology, University of Padua, Padua, Italy
  • Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Division of Gastroenterology, University of Parma, Parma, Italy
  • Marcello Picchio
    Division of Surgery, P. Colombo Hospital, ASL RM6, Velletri (RM), Italy
  • Francesco Di Mario
    Department of Clinical & Experimental Medicine, Gastroenterology Unit, University of Parma, Parma, Italy
  • the Primary Care collaborative group
    Affiliation not present

Abstract

Gastric acid secretion is believed to decrease in the aging stomach, but the number of elderly patients on proton pump inhibitor (PPI) therapy is increasing. The aim was to assess gastric function by means of serology (PGI, PGII, G17 and IgG antibodies against Helicobacter pylori) in centenarians. Twenty-five centenarians (2 males, 23 females, mean age 101.3 years, range 100- 106 years) underwent to serological gastric markers assessment by means of Gastropanel®. Patients with laboratory signs of severe oxyntic gastric atrophy (OGA) underwent gastroscopy with biopsy samples. Twelve patients (48.0%) had serological values according to normal gastric secretion; 3 patients (12%) had serological values according to severe OGA, confirmed by histology; 21 patients (84.0%) had serological values according to H. pylori infection. Acid secretion seems to be preserved in a large part of centenarians. Serological markers may be helpful to identify patients affected by OGA, in whom the administration of PPI is inappropriate.

Keywords

Centenarians; elderly; gastric function; non-invasive assessment.

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Submitted: 2017-03-03 09:09:28
Published: 2017-05-22 16:23:43
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Copyright (c) 2017 Antonio Tursi, Rudi De Bastiani, Marilisa Franceschi, Elisabetta Goni, Matteo Riccò, Marino Venerito, Massimo Rugge, Carmelo Scarpignato, Marcello Picchio, Francesco Di Mario

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