https://doi.org/10.4081/mm.2025.13691
Periorbital cellulitis with Zoster encephalitis: a case report
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Accepted: 28 February 2025
Published: 29 July 2025
Herpes Zoster, which commonly affects individuals over 60 years of age, can lead to encephalitis, particularly in elderly or immunocompromised individuals. This case highlights the development of zoster encephalitis following Herpes Zoster ophthalmicus. A 69-year-old woman presented with fever, confusion, orbital pain, and periorbital cellulitis. Her diagnosis was confirmed as Herpes Zoster ophthalmicus, with subsequent development of zoster encephalitis. The patient was treated with acyclovir for three weeks. The patient’s symptoms improved significantly after early initiation of antiviral therapy, with a reduction in periorbital edema, eye pain, and vesicular lesions. Upon discharge, the patient showed full recovery of consciousness and minimal periorbital crust lesions. Early antiviral treatment is critical for preventing complications and reducing mortality in patients with Herpes Zoster encephalitis. The zoster vaccine is recommended for individuals aged 50 and older to reduce the incidence and associated complications, such as encephalitis. This case highlights the importance of timely intervention and vaccination in prevention.
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