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Decrease of cefiderocol in vitro activity against carbapenemases-producing Gram-negative bacteria

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Received: 9 October 2024
Accepted: 17 March 2026
Published: 3 December 2024
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Klein S, Boutin S, Kocer K, Fiedler MO, Störzinger D, Weigand MA, Tan B, Richter D, Rupp C, Mieth M, Mehrabi A, Hackert T, Zimmermann S, Heeg K, Nurjadi D. Rapid development of Cefiderocol resistance in carbapenem-resistant Enterobacter cloacae during therapy is associated with heterogeneous mutations in the catecholate siderophore receptor cirA. Clinical Infectious Diseases, 2022:74 (1 March). DOI: https://doi.org/10.1093/cid/ciab511
Malik S, Kaminski M, Landman D, Quale J. Cefiderocol resistance in Acinetobacter baumannii: roles of beta-lactamases, siderophore receptors, and penicillin binding protein 3. Antimicrobial Agents and Chemotherapy, November 2020 Volume 64 Issue 11 DOI: https://doi.org/10.1128/AAC.01221-20

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Decrease of cefiderocol in vitro activity against carbapenemases-producing Gram-negative bacteria. (2024). Microbiologia Medica, 39(2). https://doi.org/10.4081/mm.2024.13226