Activity of cefiderocol against NDM-producing Enterobacterales from a regional outbreak in the Tuscany region, Italy


Published: 11 April 2023
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Authors

  • A. Bartolini Department of Experimental and Clinical Medicine, University of Florence; Clinical Microbiology Unit, Careggi University Hospital, Italy.
  • C. Niccolai Department of Experimental and Clinical Medicine, University of Florence; Clinical Microbiology Unit, Careggi University Hospital, Italy.
  • M. Coppi Department of Experimental and Clinical Medicine, University of Florence; Clinical Microbiology Unit, Careggi University Hospital, Italy.
  • E. Andreoli Microbiology Laboratory, FL Hospital of Pontedera, Pisa, Italy.
  • L. Bianchi SOS Microbiology and Virology, S. Jacopo Hospital, Pistoia, Italy.
  • T. Brunelli Clinical Pathology and Microbiology Unit, S. Stefano Hospital, Prato, Italy.
  • C. Fornai Chemical-Clinical Analysis Laboratory, Livorno Territorial Area, Livorno, Italy.
  • I. Montenora Microbiology Unit, S. Giuseppe Hospital, Empoli, Italy.
  • M. Nardone UOC Chemical-Clinical Analysis Laboratory, S. Luca Hospital, Lucca, Italy.
  • E. M. Parisio UOSD Microbiology, S. Donato Hospital, Arezzo, Italy.
  • E. Riccobono Department of Medical Biotechnologies, University of Siena, Italy.
  • S. Valentini Infectious Diseases Department, Misericordia Hospital, Grosseto, Italy.
  • E. Mantengoli Infectious and Tropical Disease Unit, Florence Careggi Hospital, Florence; Hospital Infection Prevention and Control Unit, Florence Careggi University Hospital, Florence, Italy.
  • A. Antonelli Department of Experimental and Clinical Medicine, University of Florence; Clinical Microbiology Unit, Careggi University Hospital, Italy.
  • T. Giani Department of Experimental and Clinical Medicine, University of Florence; Clinical Microbiology Unit, Careggi University Hospital, Italy.
  • G. M. Rossolini Department of Experimental and Clinical Medicine, University of Florence; 2 Clinical Microbiology Unit, Careggi University Hospital, Italy.

Not available.


Hackel MA, Tsuji M, Yamano Y, Echols R, Karlowsky JA, Sahm DF. In vitro activity of the siderophore cephalosporin, cefiderocol, against carbapenem-nonsusceptible and multidrug-resistant isolates of Gram-negative bacilli collected

worldwide in 2014 to 2016. Antimicrobial Agents Chemother 2018; 62:e01968-17.

Di Pilato V, Henrici De Angelis L, Aiezza N et al. Resistome and virulome accretion in an NDM-1-producing ST147 sublineage of Klebsiella pneumoniae associated with an outbreak in Tuscany, Italy: a genotypic and phenotypic

characterisation. Lancet Microbe. 2022;3:e224-e234. DOI: https://doi.org/10.1016/S2666-5247(21)00268-8

Coppi M, Antonelli A, Niccolai C et al. Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022. Euro Surveill. 2022;27:2200795. DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.43.2200795

Hackel MA, Tsuji M, Yamano Y et al. Reproducibility of broth microdilution MICs for the novel siderophore cephalosporin, cefiderocol, determined using iron-depleted cation-adjusted Mueller-Hinton broth. Diagn Microbiol Infect Dis.

;94:321-325.

Bartolini, A., Niccolai, C., Coppi, M., Andreoli, E., Bianchi, L., Brunelli, T., Fornai, C., Montenora, I., Nardone, M., Parisio, E. M., Riccobono, E., Valentini, S., Mantengoli, E., Antonelli, A., Giani, T., & Rossolini, G. M. (2023). Activity of cefiderocol against NDM-producing <i>Enterobacterales</i> from a regional outbreak in the Tuscany region, Italy. Microbiologia Medica, 38(1). https://doi.org/10.4081/mm.2023.11365

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