Risk factors matter: case report of <I>Y. pseudotuberculosis</I> in obese patient

Lara Scoppapietra; Giuseppina Amarù; Cristina Crocillà; Mara Finotti; Marika Salafia; Alessandra Canevaro; Valentino Granero

doi:10.4081/mm.2022.10784

Authors

Lara Scoppapietra S.C. Laboratorio Analisi Unificato Rivoli-Pinerolo ASL TO3, Rivoli (TO), Italy.
Giuseppina Amarù S.C. Laboratorio Analisi Unificato Rivoli-Pinerolo ASL TO3, Rivoli (TO), Italy.
Cristina Crocillà S.C. Banca del Sangue e Immunoematologia, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Mara Finotti S.C. Banca del Sangue e Immunoematologia, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Marika Salafia S.C. Banca del Sangue e Immunoematologia, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Alessandra Canevaro S.C. Laboratorio Analisi Chimico-Cliniche e Microbiologia. Azienda Ospedaliera Ordine Mauriziano, Turin, Italy.
Valentino Granero
giantinox@libero.it
S.C. Banca del Sangue e Immunoematologia, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.

Yersinia pseudotuberculosis is a Gram-negative bacillus that can occasionally cause zoonosis. Infections of this bacterium typically present as self-limiting ileitis, often accompanied by diarrhea, but, especially in the case of immunocompromised patients, can also lead to serious secondary complications which, if not treated properly, can progress with a poor prognosis. Here, we present a case of successfully treated bacteremia due to Y. pseudotuberculosis in a multipathological obese patient. The diagnosis was possible through blood culture, and this highlights the importance of the search for unconventional pathogens, especially in certain categories of patients whose risk factors are strongly indicative and suggestive.

Delchier JC, Constantini D., Soule JC. Presence of anti-Yersinia pseudotuberculosis agglutinins during a flare-up of ileal Crohn's disease. Apropos of 3 cases. Gastroenterol Clin Biol 1983;7:580-4.

Fukushima H, Gomyoda M, Ishikura S, et al. Cat-contaminated environmental substances lead to Yersinia pseudotuberculosis infection in children. J Clin Microbiol 1989;27:2706–09. DOI: https://doi.org/10.1128/jcm.27.12.2706-2709.1989

Galindo CL, Rosenzweig JA, Kirtley ML, et al. Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis. J Pathogens 2011;2011:182051. DOI: https://doi.org/10.4061/2011/182051

Hashimoto T, Takenaka R, Fukuda H, et al. Septic shock due to Yersinia pseudotuberculosis infection in an adult immunocompetent patient: a case report and literature review. BMC Infect Dis. 2021;7;21:36. DOI: https://doi.org/10.1186/s12879-020-05733-w

Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obes (Lond) 2013;37:333-40. DOI: https://doi.org/10.1038/ijo.2012.62

Jiang C, Chen Q, Xie M. Smoking increases the risk of infectious diseases: A narrative review. Tob Induc Dis. 2020;14:18-60. DOI: https://doi.org/10.18332/tid/123845

Lee YJ, Kim J, Jeon JH, et al. Extraintestinal Manifestation of Yersinia pseudotuberculosis Bacteremia as Acute Hepatitis: Case Report and Review of the Literature. Pathogens 2021;28;10:1255. DOI: https://doi.org/10.3390/pathogens10101255

Mead PS. “231-Yersinia Species (Including Plague)”, in Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th ed.”, Elsevier, 2015. DOI: https://doi.org/10.1016/B978-1-4557-4801-3.00231-9

Stecher B. The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection. Microbiol Spectr. 2015;3. DOI: https://doi.org/10.1128/microbiolspec.MBP-0008-2014

Supporting Agencies

None

Scoppapietra, L., Amarù, G., Crocillà, C., Finotti, M., Salafia, M., Canevaro, A., & Granero, V. (2022). Risk factors matter: case report of <I>Y. pseudotuberculosis</I> in obese patient. Microbiologia Medica, 37(2). https://doi.org/10.4081/mm.2022.10784