Acute Hepatitis HCV genotype 3h: virological baseline characterization and monitoring “On Therapy”

  • Giuseppe Sodano | giuseppe.sodano@ospedalemonaldi.it
  • Erasmo Falco
  • Adriana Raddi
  • Maria Grimaldi
  • Francesco Labonia
  • Marcello Raffone
  • Mariano Bernardo
  • Emanuele Durante Mangoni

Abstract

The Hepatitis C viral genome is highly variable and is classified into 6 genotype groups, based on phylogenetic analysis of the genomic sequence. Here we show a case of acute Hepatitis C in which a rare genotype 3h was evidenced by direct RNA sequencing.We confirm that analysis of the early kinetics of HCV RNA during antiviral therapy is an important prognostic parameter, and that a (to-t3)log10HCV RNA value is a strong predictor for Rapid Virological Response (RVR) and End Therapy Response (ETR).

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Published
2010-12-31
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Section
Original Articles
Keywords:
HCV-RNA, Genotype, First-phase kinetics, Sequenziament
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How to Cite
Sodano, G., Falco, E., Raddi, A., Grimaldi, M., Labonia, F., Raffone, M., Bernardo, M., & Mangoni, E. (2010). Acute Hepatitis HCV genotype 3h: virological baseline characterization and monitoring “On Therapy”. Microbiologia Medica, 25(4). https://doi.org/10.4081/mm.2010.2411

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