Cover Image

Integration of microbiological, epidemiological and next generation sequencing technologies data for the managing of nosocomial infections

Matteo Brilli, Francesco Comandatore, Aurora Piazza, Gian Vincenzo Zuccotti, Claudio Bandi
  • Matteo Brilli
    SkyNet UNIMI Laboratory - Piattaforma di Epidemiologia Genomica e Microbiologia Sperimentale, Pediatric Research Center Romeo ed Enrica Invernizzi, "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Italy
  • Francesco Comandatore
    SkyNet UNIMI Laboratory - Piattaforma di Epidemiologia Genomica e Microbiologia Sperimentale, Pediatric Research Center Romeo ed Enrica Invernizzi, "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Italy
  • Aurora Piazza
    SkyNet UNIMI Laboratory - Piattaforma di Epidemiologia Genomica e Microbiologia Sperimentale, Pediatric Research Center Romeo ed Enrica Invernizzi, "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Italy
  • Gian Vincenzo Zuccotti
    SkyNet UNIMI Laboratory - Piattaforma di Epidemiologia Genomica e Microbiologia Sperimentale, Pediatric Research Center Romeo ed Enrica Invernizzi, "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Italy
  • Claudio Bandi
    SkyNet UNIMI Laboratory - Piattaforma di Epidemiologia Genomica e Microbiologia Sperimentale, Pediatric Research Center Romeo ed Enrica Invernizzi, "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Italy | claudio.bandi@unimi.it

Abstract

At its core, the work of clinical microbiologists consists in the retrieving of a few bytes of information (species identification; metabolic capacities; staining and antigenic properties; antibiotic resistance profiles, etc.) from pathogenic agents. The development of next generation sequencing technologies (NGS), and the possibility to determine the entire genome for bacterial pathogens, fungi and protozoans will likely introduce a breakthrough in the amount of information generated by clinical microbiology laboratories: from bytes to Megabytes of information, for a single isolate. In parallel, the development of novel informatics tools, designed for the management and analysis of the so-called Big Data, offers the possibility to search for patterns in databases collecting genomic and microbiological information on the pathogens, as well as epidemiological data and information on the clinical parameters of the patients. Nosocomial infections and antibiotic resistance will likely represent major challenges for clinical microbiologists, in the next decades. In this paper, we describe how bacterial genomics based on NGS, integrated with novel informatic tools, could contribute to the control of hospital infections and multi-drug resistant pathogens.

Keywords

next generation sequencing technologies, nosocomial infections, multi-drug resistant pathogens

Full Text:

PDF
HTML
Submitted: 2018-02-19 08:29:54
Published: 2018-02-27 11:09:37
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
493

Views:
PDF
55
HTML
99

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2017 Claudio Bandi

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy