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In vitro effects of glycyrrhetinic acid and hyaluronic acid on the growth of vulvovaginal Candida albicans and other yeasts

Martina Stevan, Eleonora Fusato, Decio Armanini, Giulio Bertoloni, Francesco De Seta, Christian Leli, Mario Rassu
  • Martina Stevan
    U.O.C. Microbiology and Virology, S. Bortolo Hospital, Vicenza, Italy
  • Eleonora Fusato
    U.O.C. Microbiology and Virology, S. Bortolo Hospital, Vicenza, Italy
  • Decio Armanini
    Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
  • Giulio Bertoloni
    Department of Molecular Medicine, Padua, Italy
  • Francesco De Seta
    Department of Obstetrics and Gynecology, IRCCS Burlo Garofolo, University of Trieste, Italy
  • Christian Leli
    Department of Experimental Medicine, Microbiology Section, University of Perugia, Italy


Aims. The present study aimed to test the in vitro activity against Candida albicans and non-albicans strains of 18-β glycyrrhetinic acid (18-β GA) and hyaluronic acid (HA), both alone and in combination. This antimicrobial activity was assessed using the National Committee for Clinical Laboratory Standards (NCCLS) method on Candida strains that were isolated from patients with recurrent vulvovaginal candidiasis (RVVC).
. Our results demonstrate that the anti-Candida activity is independent from antifungal susceptibility level and the fact that the growth inhibition is stronger at acidic pH level makes the two drugs a promising biological alternative for the topical treatment of vulvovaginal candidiasis (VVC) and RVVC.
. Furthermore, the reduction of both budding cells formation and germ tube elongation, on mammalian cell monolayers, may explain the observed growth inhibition and suggest a decreased virulence, respectively.


18-β glycyrrhetinic acid; hyaluronic acid, Candida albicans; Candida non-albicans; recurrent vulvovaginal candidiasis.

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Submitted: 2017-08-02 17:18:52
Published: 2017-12-30 00:00:00
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