In the last years there has been worldwide an increase in the incidence of Streptococcus pyogenes infections and its sequelae. The purpose of the present study is to describe a clinical case of pyoderma and cellulitis by S. pyogenes with a pattern of resistance to penicillin, erythromycin and levofloxacin. Antimicrobial susceptibility was analysed by automated method of disk diffusion while E-test method was used to verify the minimum inhibitory concentration to penicillin, erythromycin and levofloxacin. Although penicillin remains the first-choice treatment for S. pyogenes infection, worldwide antibiotic resistance and the associated phenotypes are highly variable across countries. This case report strengthens the need for continued surveillance to obtain further insights into the forces governing resistance in S. pyogenes.
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