Monotest in the complement fixation test: the Chorus system

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Laura Meli *
Alessia Bogi
Grazia Dal Maso
Francesco Rosini
(*) Corresponding Author:
Laura Meli | laurameli@diesse.it

Abstract

The complement fixation test (CFT) is a method used for the detection of antibodies against pathogens of infectious diseases, it has been proved to be a useful diagnostic method in the detection of acute disease in many medical laboratories.The test performed manually is time consuming and needs very skilled personnel.This study evaluates the automated Chorus CFT system with 87 serum samples in comparison with manual method using Virion-Serion reagents, against a panel of antigens, such as Adenovirus, Influenza A and B virus, Respiratory Syncythial Virus, Parainfluenza Mix, Mycoplasma Pneumoniae, and Echinococcus. The Chorus system includes standardized reagents and a monotest device to perform the single assay. In comparison to the manual CFT method, the correlation is 91.6% (7/83).The results obtained show that the automated Chorus system can be applied for detecting complement fixation antibodies against different infectious disease agents.

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