Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes
Abstract
The mitogen-activated protein kinase (MAPK) cascade in Xenopus oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found to be strongly ultrasensitive. We argue that underlying this behaviour is a regulation motif akin to a feed-forward loop acting in vivo.Downloads
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Published
2013-01-30
Keywords:
MAPK, ultrasensitivity, feed-back, protein synthesis, regulation motif.
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How to Cite
Beaujois, R., Riquet, F., Cailliau, K., Browaeys-Poly, E., Russo, C., Blossey, R., Vicogne, D., Marin, M., Lescuyer-Rousseau, A., Vilain, J.-P., & Bodart, J.-F. (2013). Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes. MAP Kinase, 2(1), e2. https://doi.org/10.4081/mk.2013.e2
Copyright (c) 2013 Rémy Beaujois, Franck Riquet, Katia Cailliau, Edith Browaeys-Poly, Christophe Russo, Ralf Blossey, Dorothée Vicogne, Matthieu Marin, Arlette Lescuyer-Rousseau, Jean-Pierre Vilain, Jean-François Bodart

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