Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes

Main Article Content

Rémy Beaujois *
Franck Riquet
Katia Cailliau
Edith Browaeys-Poly
Christophe Russo
Ralf Blossey
Dorothée Vicogne
Matthieu Marin
Arlette Lescuyer-Rousseau
Jean-Pierre Vilain
Jean-François Bodart
(*) Corresponding Author:
Rémy Beaujois | jean-francois.bodart@univ-lille1.fr


The mitogen-activated protein kinase (MAPK) cascade in Xenopus oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found to be strongly ultrasensitive. We argue that underlying this behaviour is a regulation motif akin to a feed-forward loop acting in vivo.


Download data is not yet available.

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

Article Details